Term
| Do human tumors follow skipper's laws (log kill) or Gomptertzian (non-linear growth curve) |
|
Definition
|
|
Term
| T or F the best time to hit cancer cells with drug is when tumor is large |
|
Definition
| False when turmor is small and growth fraction is high (Gompertzian model) |
|
|
Term
| T or F Goldie-Coldman hypothesis describes that tumor cells have higher mutation rate than normal and a constant mutation rate |
|
Definition
| False- with tumor growth mutation rate increases |
|
|
Term
| T or F nitrosoureas acts similiar to alkylating agents but is lipid soluble and can cross the blood brain barrier |
|
Definition
|
|
Term
| what class of chemotherapy drug acts to inhibit tubulin and thus inhibit the mitotic spindle |
|
Definition
|
|
Term
| What class of chemodrugs all discrupt DNA funt and must administered intravenously |
|
Definition
|
|
Term
| what drug class acts like an alkylating agent by binding DNA at N7 guanine position; uses metal complex |
|
Definition
|
|
Term
What drug blocks the conversion of folic acid to tetrahydrofolate by inhibiting DHFR?
A. methotrexate
B. 5-FU |
|
Definition
|
|
