Alkylating Agents

Nitrogen Mustards

Cyclophosphamide (Cytoxan®)

Ifosfamide (Ifex®)

Mechlorethamine (Mustargen®)

Melphalan (Alkeran®)

Chlorambucil (Leukeran®)

Estramustine (Emcyt®)

MOA: Alkylates and crosslinks DNA

Cyclophosphamide

Cytoxan®

Nitrogen Mustard (Alkylating Agent)

Ifosfamide

Ifex®

Nitrogen Mustard (Alkylating Agent)

Mechlorethamine

Mustargen®

Nitrogen Mustard (Alkylating Agent)

Melphalan

Alkeran®

Nitrogen Mustard (Alkylating Agent)

Chlorambucil

Leukeran®

Nitrogen Mustard (Alkylating Agent)

Estramustine

Emcyt®

Nitrogen Mustard (Alkylating Agent)

Alkylating Agents

Nitrosoureas

Carmustine (BiCNU®)

Lomustine (CeeNU®)

Streptozocin (Zanosar®)

MOA: Alkylates and crosslinks DNA

Carmustine

BiCNU®

Nitrosourea (Alkylating Agent)

 Lomustine

CeeNU®

Nitrosourea (Alkylating Agent)

Streptozocin

Zanosar®

Nitrosourea (Alkylating Agent)

Alkylating Agents

Platinum Analogs

Cisplatin (Platinol®)

Carboplatin (Paraplatin®)

Oxaliplatin (Eloxatin®)

MOA: Binds and crosslinks DNA

Cisplatin

Platinol®

Platinum Analog (Alkylating Agent)

Carboplatin

Paraplatin®

Platinum Analog (Alkylating Agent)

Oxaliplatin

Eloxatin®

Platinum Analog (Alkylating Agent)

Alkylating Agents

Other

Busulfan (Myleran®)

Thiotepa

Procarbazine (Matulane®)

Dacarbazine (DTIC-Dome®)

Temozolomide (Temodar®)

MOA: Binds and crosslinks DNA

Busulfan

Myleran®

Other (Alkylating Agent)

Thiotepa

No Brand Name

Other (Alkylating Agent)

Procarbazine

Matulane®

Other (Alkylating Agent)

Dacarbazine

DTIC-Dome®

Other (Alkylating Agent)

Temozolomide

Temodar®

Other (Alkylating Agent)

Antimetabolites

Folate Analogs

Methotrexate (Rheumatrex®)

Pemetrexed (Alimta®)

MOA: Inhibits dihydrofolate reductase and lymphocyte proliferation

Methotrexate

Rhematrex®, Trexall®

Folate Analog (Antimetabolite)

Pemetrexed

Alimta®

Folate Analog (Antimetabolite)

Antimetabolites

Pyrimidine Analogs

5-Fluorouracil (Efudex®)

Cytarabine (Cytosar-C®)

Gemcitabine (Gemzar®)

Capecitabine (Xeloda®)

Azacitidine (Vidaza®)

MOA: Inhibits DNA and RNA synthesis

 5-Fluorouracil

Efudex®, Adrucil®

Pyrimidine Analog (Antimetabolite)

Cytarabine

Cytosar-C®, Ara-C

Pyrimidine Analog (Antimetabolite)

Gemcitabine

Gemzar®

Pyrimidine Analog (Antimetabolite)

Capecitabine

Xeloda®

Pyrimidine Analog (Antimetabolite)

Azacitidine

Vidaza®

Pyrimidine Analog (Antimetabolite)

Antimetabolites

Purine Analogs

6-Mercaptopurine (Purinethol®)

6-Thioguanine (Tabloid®)

Fludarabine (Fludara®)

Cladribine (Leustatin®)

MOA: Inhibits DNA synthesis; Inhibits DNA polymerase alpha, DNA primase, and ribonucleotide reductase

6-Mercaptopurine

Purinethol®

Purine Analog (Antimetabolite)

6-Thioguanine

Tabloid®

Purine Analog (Antimetabolite)

Fludarabine

Fludara®

Purine Analog (Antimetabolite)

Cladribine

Leustatin®

Purine Analog (Antimetabolite)

Mitosis Inhibitors

Vinca Alkaloids

Vinblastine

Vincristine (Oncovin®)

Vinorelbine (Navelbine®)

MOA: Inhibits microtubule formation, arresting mitosis in metaphase

Vinblastine

No Brand Name

Vinca Alkaloids (Mitosis Inhibitor)

Vincristine

Oncovin®, Vincasar® PFS

Vinca Alkaloid (Mitosis Inhibitor)

Vinorelbine

Navelbine®

Vinca Alkaloid (Mitosis Inhibitor)

 Mitosis Inhibitors

Taxanes 

Paclitaxel (Taxol®)

Nab-paclitaxel (Abraxane®)

Docetaxel (Taxotere®)

Carbazitaxel (Jevtana®)

MOA: Promotes formation and inhibits disassembly of stable microtubules, inhibiting mitosis

Paclitaxel

Taxol®

Taxane (Mitosis Inhibitor)

Nab-Paclitaxel

Abraxane®

Taxane (Mitosis Inhibitor)

Docetaxel

Taxotere®

Taxane (Mitosis Inhibitor)

Carbazitaxel

Jevtana®

Taxane (Mitosis Inhibitor)

Mitosis Inhibitors

Topoisomerase Inhibitors

Etoposide (Etopophos®)

Teniposide (Vumon®)

Irinotecan (Camptosar®)

MOA: Binds to topoisomerase I-DNA complexes, preventing religationof single-strand breaks

Etoposide

Etopophos®

Topoisomerase Inhibitor (Mitosis Inhibitor)

Teniposide

Vumon®

Topoisomerase Inhibitor (Mitosis Inhibitor)

Irinotecan

Camptosar®

Topoisomerase Inhibitor (Mitosis Inhibitor)

Antitumor Antibiotics

Bleomycin (Blenoxane®)

Dactinomycin (Actinomycin-D®)

Mitomycin (Mutamycin®)

MOA: Inhibits DNA synthesis

Bleomycin

Blenoxane®

Antitumor Antibiotic

Dactinomycin

Actinomycin D®, Cosmegen®

Antitumor Antibiotic

Mitomycin-C

Mutamycin®

Antitumor Antibiotic

Anthracyclines

Doxorubucin (Adriamycin®)

Daunorubicin (Cerubidine®)

Idarubicin (Idamycin® PFS)

Epirubicin (Ellence®)

Valrubicin (Valstar®)

Mitoxantrone (Novantrone®)

MOA: Binds and intercalates into DNA, inhibiting nucleic acid and protein synthesis; triggers DNA cleavage by topoisomerase II

Doxorubicin

Adriamycin®

Anthracycline

Daunorubicin

Cerubidine®

Anthracycline

Idarubicin

Idamycin® PFS

Anthracycline

Epirubicin

Ellence®

Anthracycline

Valrubicin

Valstar®

Anthracycline

Mitoxantrone

Novantrone®

Anthracycline

Antiestrogens

Tamoxifen (Soltamox®)

Anastrozole (Arimidex®)

Letrozole (Femara®)

MOA: Inhibits enzymatic androgen conversion to estrogen, reducing hormone receptor positive cancer cell growth

Tamoxifen

Soltamox®

Antiestrogen

Anastrazole

Arimidex®

Antiestrogen

Letrozole

Femara®

Antiestrogen

GnRH Agonists

Leuprolide (Lupron®)

Goserelin (Zoladex®)

MOA: Inhibits gonadotropin release, suppressing ovarian and testicular steroidogenesis

Leuprolide

Lupron®

GnRH Agonist

Goserelin

Zoladex®

GnRH Agonist

Tyrosine Kinase Inhibitors

Imatinib (Gleevec®)

Sorafenib (Nexavar®)

Vandetanib (Zactima®)

Pazopanib (Votrient®)

Gefitinib (Iressa®)

Erlontinib (Tarceva®)

Dasatinib (Sprycel®)

Nilotinib (Tasigna®)

Lapatinib (Tykerb®)

Sunitinib (Sutent®)

MOA: Inhibits intracellular tyrosine kinase domain of epidermal growth factor receptor (EGFR), resulting in cell cycle arrest and angiogenesis

Imatinib

Gleevec®

Tyrosine Kinase Inhibitor

Sorafenib

Nexavar®

Tyrosine Kinase Inhibitor

Vandetanib

Zactima®

Tyrosine Kinase Inhibitor

Pazopanib

Votrient®

Tyrosine Kinase Inhibitor

Gefitinib

Iressa®

Tyrosine Kinase Inhibitor

Erlontinib

Tarceva®

Tyrosine Kinase Inhibitor

Dasatinib

Sprycel®

Tyrosine Kinase Inhibitor

Nilotinib

Tasigna®

Tyrosine Kinase Inhibitor

Lapatinib

Tykerb®

Tyrosine Kinase Inhibitor

Sunitinib

Sutent®

Tyrosine Kinase Inhibitor

Immunotherapy

Interferon alfa-2a (Roferon®)

Interferon alfa-2b (Intron A®)

Interferon alfa-n3 (Alferon-N®)

Aldesleukin (Proleukin®)

Denileukin difitox (Ontak®)

Bacillus Calmette-Guerin (BCG)

Interferon alfa-2a

Roferon®

MOA: Inhibits cellular growth, alters the state of cellular differentiation, interferes with oncogene expression, alters cell surface antigen expression, increases phagocytic activity of macrophages and augments cytotoxicity of lymphocytes for target cells

Interferon (Immunotherapy)

Interferon alfa-2b

Intron® A

MOA: Inhibits cellular growth, alters the state of cellular differentiation, interferes with oncogene expression, alters cell surface antigen expression, increases phagocytic activity of macrophages and augments cytotoxicity of lymphocytes for target cells

Interferon (Immunotherapy)

Interferon alfa-n3

Alferon® N

MOA: Inhibits cellular growth, alters the state of cellular differentiation, interferes with oncogene expression, alters cell surface antigen expression, increases phagocytic activity of macrophages and augments cytotoxicity of lymphocytes for target cells

Interferon (Immunotherapy)

Aldesleukin

Proleukin®

MOA: Promotes proliferation, differentiation, and recruitment of T and B cells, natural killer cells, and thymocytes; causes cytolytic activity in a subset of lymphocytes and subsequent interactions stimulate the immune system and malignant cells; can stimulate lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL) cells

Immunotherapy

Denileukin difitox

Ontak®

MOA: Binds to high affinity IL-2 receptors, inhibits protein synthesis, resulting in cell death

Immunotherapy

Bacillus Calmette-Guerin

BCG

MOA: cross reacts with cytotoxic cells to cause destruction

Immunotherapy

Monoclonal Antibodies

Rituximab (Rituxan®)

Gentuzumab (Mylotarg®)

Bevacizumab (Avastin®)

Cetuximab (Erbitux®)

Trastuzumab (Herceptin®)

Ranibizumab (Lucentis®)

Panitumumab (Vectibix®)

MOA: Inhibits growth factor by binding to the outside of the cell

Rituximab

Rituxan®

Monoclonal Antibody

Gemtuzumab

Mylotarg®

Monoclonal Antibody

Bevacizumab

Avastin®

Monoclonal Antibody

Cetuximab

Erbitux®

Monoclonal Antibody

Trastuzumab

Herceptin®

Monoclonal Antibody

Ranibizumab

Lucentis®

Monoclonal Antibody

Panitumumab

Vectibix®

Monoclonal Antibody

Radiotherapeutic Agents

Chromic Phosphate

Sodium Phosphate P32

Sodium Iodide I131

Strontium 89 Chloride

Samarium SM 153 Lexidronam

None of these have brand names and he didn't state the mechanism of action

Miscellaneous Agents

Hydroxyurea (Hydrea®)

Mitotane (Lysodren®)

Tretinoin (Retin-A®)

Alitretinoin (Panretin®)

Hydroxyurea

Hydrea®

MOA: Inhibits ribonucleotide diphosphate reductase

Miscellaneous Agents

Mitotane

Lysodren®

MOA: Supresses adrenal cotrex, modifies steroid metabolism

Miscellaneous Agent

Tretinoin

Retin-A®

MOA: Induces differentiation and decreases proliferative of APL cells

Miscellaneous Agent

Alitretinoin

Parentin®

MOA: Binds to retionid receptors, inhibiting cell growth

Miscellaneous Agent

Epothilones

Sorangium cellulosum

Ixabepilone (Ixempra®)

MOA: Inhibits uritosis by the same mechanism as taxanes

Sorangium cellulosum

No Brand Name

Epothilone

Ixabepilone

Ixempra®

Epothilone

Drugs to Treat Nausea and Vomiting

Prochlorperazine (Compazine®)

Dronabinol (Marinol®)

Nabilone (Cesamet®)

Metoclopramide (Reglan®)

Ondansetron (Zofran®)

Granisetron (Kytril®)

Dolasetron (Anzemet®)

Palonsetron (Aloxi®)

Aprepitant (Emend®)

Prochlorperazine

Compazine®

Antipsychotic

Dronabinol

Marinol®

Cannabinoid Derivative

Nabilone

Cesamet®

Anti-nausea

Metoclopramide

Reglan®

D2 Inhibitor

Ondansetron

Zofran®

5HT-3 Inhibitor

Granisetron

Kytril®

5HT-3 Inhibitor

Dolasetron

Anzemet®

5HT-3 Inhibitor

Palonsetron

Aloxi®

5HT-3 Inhibitor

Aprepitant

Emend®

5HT-3 Inhibitor

Drugs to Treat Hyperuricemia

Allopurinol (Zyloprim®)

Febuxostat (Uloric®)

Allopurinol

Zyloprim®

Xanthine Oxidase Inhibitor

Febuxostat

Uloric®

Xanthine Oxidase Inhibitor

Drugs Used with Chemotherapy

Mesna (Mesnex®)

Leucovorin (Wellcovorin®)

Mesna

Mesnex®

Used with cyclophosphamide and ifosfamide to prevent hemorrhagic cystitis

Leucovorin

Wellcovorin®

Used with 5-FU and Methotrexate