Term
|
Definition
Locks in Tubulin Polymerization during Mitosis
Causes neuropathy and hypersensitivity (treat with NSAIDS)
CAN CAUSE ARRYTHMIAS
Metabolised by P450 |
|
|
Term
|
Definition
Inhibits Tubulin Polymerization (antagonist to paclitaxel)
Causes Neuropathy due to decrease axonal transport
Used for LYMPHOMA/LEUKEMIA |
|
|
Term
| doxirubicine (adriamycin) |
|
Definition
Binds to DNA topoisomerase II to prevent RNA polymerization
Cardiotoxic but preventable with dezroxane
TURNS URINE RED
Metabolised BIPHASIC P450 |
|
|
Term
|
Definition
actinomycin D
WILMS TUMOR AND RHABDOMYCO
Inhibits RNA polymerization by binding to DNA |
|
|
Term
| Cyclophosphamide (cytoxan) |
|
Definition
Transfers alkyl groups to cross link DNA
Causes Bone Marrow Myelosupression
Activated in the liver |
|
|
Term
|
Definition
Anti DHFR --> Prevents cellular creation DNA
Severe interactions Salicate/Sulfonimides/Phenytoin
Tendancy to accumulate in fluids (retroperitoneal/pleural)
Good for Leukemia |
|
|
Term
|
Definition
Inhibits Thymidine Syntase (pyridimine synthesis)
Degraded by dihydropyridine dehydrogenase (some individuals lack) |
|
|
Term
|
Definition
Anti-Estrogen Receptor
Causes Hot Flashes
Vaginal Lining Atrophy
2X chance endometrial Cancer
T1/2 = 2 weeks |
|
|
Term
|
Definition
Inhibits cyp/aromatase irreversibly
Given Second but more effective than tamoxifen |
|
|
Term
|
Definition
| Helps with chemotherapeutic induced neutropenia |
|
|
Term
|
Definition
| Anti-HT3 medulla receptor to prevent emesis (vomiting) |
|
|
Term
|
Definition
Adreno-corticosteroid with potent lympholytic activity
Used leukemia/lymphoma
Inflammation/nausea/breat cancer also |
|
|
Term
|
Definition
| Her2Neu antibody Trastuzumab |
|
|
Term
|
Definition
Platinum derived DNA alkylator/crosslinker used to treat lung cancer
Nephrotoxic (short T1/2 long excretion) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| antibody against BCR/ABL translocation |
|
|
Term
|
Definition
Gonoadotrop releasing Hormone (GRH):
causes massive release LH--> massive spike testosterone followed by desensitization and loss test. release.
Treat spike with AR inhibitors |
|
|
Term
|
Definition
Nonsteroidal androgen receptor inhibitor
Causes liver damage |
|
|
Term
|
Definition
| DNA cross-linker/alkylator for brain cancer |
|
|
