Term
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Definition
| leukemia, lymphomas, rapid response, myeloma, |
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Term
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Definition
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Term
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Definition
| age genetics FH reproductive hx (nuliparity/early menses), race obesity ETOH, |
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Term
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Definition
| ER+ cancers, stop endogenous estrogen first (oopherectomy)....breast, endometrial ovarian melanoma....may inc uterine cancer risks |
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Term
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Definition
| blocks adrenal estrogen (aromatase), breast cancer...eg. anastrazole/letrazole |
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Term
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Definition
| prostate cancer, dec test ....leuprolide, duserelin goserelin |
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Term
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Definition
| flutamide, bicalutamide .... prostate cancer |
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Term
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Definition
| experimental...used for male breast cancer (so is flutamide) also used for prostate cancer |
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Term
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Definition
| estradiol/NM ... prostate cancer |
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Term
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Definition
| tyrosine kinase linked to RAS which leads to prolif... VEGF,PDGF,EGF,HER2(ERD2) |
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Term
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Definition
iressa (gefitinib) tarceva (erlotinib)
NSSLC/Pancreatic (terceva only) |
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Term
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Definition
| sutent (sunitinib) [VEGF&GIST] & nexavar (sorafenib) renal cell cancer |
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Term
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Definition
| (ERD2) lapatnib - advanced breast cancer |
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Term
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Definition
| bcr-akb TK...aberrant philly chromosome in CML .... also GIST |
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Term
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Definition
| dipeptidyl boronic acid - mult myloma- blocks proteosomic degridation of IKBa allowing it to stabilize NFKB (holds p50/p65) preventing transcription |
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Term
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Definition
| prevent RAS from sticking to farnesyl so it cannont stick to cell membrane |
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Term
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Definition
| new MM, given with dex ... TNF alpha ...cytokines ...thrombosis, neuropathy insomnia |
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Term
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Definition
| transcription, division, metabolism, tumor suppressor |
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Term
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Definition
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Term
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Definition
| broad increase in immune response ...aids/hcl |
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Term
| G-csf, gm-csf, pegfilgrastin |
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Definition
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