Shared Flashcard Set

Details

chemo drugs....more
.....
21
Medical
Graduate
12/13/2006

Additional Medical Flashcards

 


 

Cards

Term
corticosteroids
Definition
leukemia, lymphomas, rapid response, myeloma,
Term
progestins
Definition
endometrial cancer
Term
breast cancer risks
Definition
age genetics FH reproductive hx (nuliparity/early menses), race obesity ETOH,
Term
tamoxifen
Definition
ER+ cancers, stop endogenous estrogen first (oopherectomy)....breast, endometrial ovarian melanoma....may inc uterine cancer risks
Term
aminoflutethimide
Definition
blocks adrenal estrogen (aromatase), breast cancer...eg. anastrazole/letrazole
Term
gnrh agosnists
Definition
prostate cancer, dec test ....leuprolide, duserelin goserelin
Term
test receptor antag
Definition
flutamide, bicalutamide .... prostate cancer
Term
testesterone vaccine
Definition
experimental...used for male breast cancer (so is flutamide) also used for prostate cancer
Term
estramustine
Definition
estradiol/NM ... prostate cancer
Term
growth factors
Definition
tyrosine kinase linked to RAS which leads to prolif... VEGF,PDGF,EGF,HER2(ERD2)
Term
EGF
Definition
iressa (gefitinib) tarceva (erlotinib)
NSSLC/Pancreatic (terceva only)
Term
PDGF
Definition
sutent (sunitinib) [VEGF&GIST] & nexavar (sorafenib) renal cell cancer
Term
HER2
Definition
(ERD2) lapatnib - advanced breast cancer
Term
gleevec (imatinib)
Definition
bcr-akb TK...aberrant philly chromosome in CML .... also GIST
Term
velcade (bortezomib)
Definition
dipeptidyl boronic acid - mult myloma- blocks proteosomic degridation of IKBa allowing it to stabilize NFKB (holds p50/p65) preventing transcription
Term
FT blockers
Definition
prevent RAS from sticking to farnesyl so it cannont stick to cell membrane
Term
thalidomide
Definition
new MM, given with dex ... TNF alpha ...cytokines ...thrombosis, neuropathy insomnia
Term
p53
Definition
transcription, division, metabolism, tumor suppressor
Term
interleukin 2
Definition
increased T cells
Term
interferon alpha
Definition
broad increase in immune response ...aids/hcl
Term
G-csf, gm-csf, pegfilgrastin
Definition
inc WBC
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