Term
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Definition
| NM alkylator, non-enzymatic activation, hodgkins disease, (MOPP) |
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Term
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Definition
| NM alkylator, CYP activation, burketts, ALL, |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| alkyl sulphonate, CGL, effects only marrow (not lymphoid) |
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Term
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Definition
| carmustine, lomustine, inhibit dna, rna & protien synth...lipophillic - brain tumors |
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Term
| imidazoetriazines (temozolomide) |
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Definition
| triazine. spon activation, melanoma & astrocytoma |
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Term
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Definition
| triazine, CYP activation, inhibirs rna/protien, melanoma |
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Term
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Definition
| inorganic guanine crosslinker, testicular&ovarian .. cumulative renal toxicity |
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Term
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Definition
| inhibits DHFR blocking THF (used to synth a precurser to thymidylate synthatase), S phase specific, resistance via dec influx, DHFR affinity. used in ALL and choriocarcinoma. use leucovorin rescue to regain NN-methylene-FH4. used in autoimmune disease at lower dose with folic acid as rescue |
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Term
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Definition
| folate antagonist for mesothelioma and other lung cancers |
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Term
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Definition
| hypoxanthine analog (purine), blocks HGPRT which blocks DNA synth. (S-phase). Metabolized by xanthine oxidase which can be inhibited by allopurinol (significant DDI) |
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Term
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Definition
| guanine analog, blocks HGPRT which blocks DNA synth. (S-phase). leukemia |
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Term
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Definition
| purine analog, inhibits DNA synth, Leukemia |
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Term
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Definition
| purine analog, CLL, inhibits DNA and induces apoptosis |
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Term
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Definition
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Term
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Definition
| adenine analog (inhibits adenine deaminase), HCL |
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Term
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Definition
| enzymatically activated to 5'MP nucleotide and inhibits thymidylate synthetase, breast cancer and psoriasis ... infusion=DNA bolus=RNA |
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Term
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Definition
| prodrug to flourouracil - breast cancer |
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Term
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Definition
| pyrimidine analog, S phase specific, used in ALL, activated via kinase...deactivated via deaminase ...(resistance via either) |
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