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Chemo Drugs Adverse Effects
Select Adverse Effects for chemo drugs
68
Pharmacology
Post-Graduate
03/18/2012

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Cards

Term
Vinblastine
Definition
Neurotoxicity, Myelosuppression, Vesicant
Term
Vinorelbine
Definition
Neurotoxicity, Myelosuppression, Vesicant
Term
Vincristine
Definition
Neurotoxicity & Vesicant
Term
Paclitaxel
Definition
- Neurotoxicity
- Alopecia
- Myelosuppression (numbness & tingling)
- Vesicant in High Doses

* give BEFORE platinums
Term
Docetaxel
Definition
- Neurotoxicity
- Alopecia
- Myelosuppression (numbness & tingling)
- Vesicant in High Doses

* give BEFORE platinums
Term
Cabazetaxel
Definition
- Neurotoxicity
- Alopecia
- Myelosuppression (numbness & tingling)
- Vesicant in High Doses

* give BEFORE platinums
Term
Doxorubicin
Definition
- Cardiotoxicity!!
- Myelosuppression
- Mucositis
- Vesicant
Term
Daunorubicin
Definition
- Cardiotoxicity!!
- Myelosuppression
- Mucositis
- Vesicant
Term
Epirubicin
Definition
- Cardiotoxicity!!
- Myelosuppression
- Mucositis
- Vesicant
Term
Idarubicin
Definition
- Cardiotoxicity!!
- Myelosuppression
- Mucositis
- Vesicant
Term
Mitoxantrone
Definition
Myelosuppression & conjunctivitis
Term
Etoposide
Definition
Myelosuppression
Mucositis
Hypersensitivity
Term
Teniposide
Definition
Myelosuppression
Mucositis
Hypersensitivity
Term
Irinotecan
Definition
Diarrhea (early: cholinergic & late)
Myelosuppression
Term
Topotecan
Definition
Myelosuppression
Term
Cladribine
Definition
- Myelosuppression
- Immunosuppression
- Flu-like symptoms
- rash
Term
Fludarabine
Definition
- Myelosuppression
- Immunosuppression
- Flu-like symptoms
- rash
Term
Mercaptopurine
Definition
- Myelosuppression
- Immunosuppression
- Flu-like symptoms
- rash
Term
Fluorouracil (5-FU)
Definition
- Myelosuppression
- Mucosal damage
- Palmar-Plantar erythrodysethesia
Term
Capecitabine
Definition
- Myelosuppression
- Mucosal damage
- Palmar-Plantar erythrodysethesia
Term
Cytarabine
Definition
- Myelosuppression
- Mucosal damage
Term
Gemcitabine
Definition
- Myelosuppression
- Mucosal damage
Term
Methotrexate
Definition
- Myelosuppression
- Mucositis
- nephrotoxicity
- CI in pts with 3rd spacing
Term
Pemetrexed
Definition
- Myelosuppression
- Mucositis
- CI in pts with 3rd spacing
Term
Bleomycin
Definition
- Pulmonary toxicity!!
- Rash
- PPE
- Hypersensitivity
Term
Tamoxifen
Definition
Hot flashes, mood, visual changes, bleeding, endometrial cancer, clots
Term
Anastrazole (Arimidex)
Definition
- Hot flashes
- bone fractures
- clots
- ↑lipids
- fatigue/depression/anxiety
- insomnia
- mild nausea/anorexia
- edema
- dyspnea
- ↑ transaminases
Term
Letrizole (Femara)
Definition
- Hot flashes
- bone fractures
- clots
- ↑lipids
- fatigue/depression/anxiety
- insomnia
- mild nausea/anorexia
- edema
- dyspnea
- ↑ transaminases
Term
Extramestane (Aromasin)
Definition
- Hot flashes
- bone fractures
- clots
- ↑lipids
- fatigue/depression/anxiety
- insomnia
- mild nausea/anorexia
- edema
- dyspnea
- ↑ transaminases
Term
Leuprolide
Definition
- Gynecomastia/small balls
- hot flash
- impotence
- osteoporosis
- CV disease
- ↓ insulin sensitivity
Term
Goserelin
Definition
- Gynecomastia/small balls
- hot flash
- impotence
- osteoporosis
- CV disease
- ↓ insulin sensitivity
Term
Historelin
Definition
- Gynecomastia/small balls
- hot flash
- impotence
- osteoporosis
- CV disease
- ↓ insulin sensitivity
Term
Triptorelin
Definition
- Gynecomastia/small balls
- hot flash
- impotence
- osteoporosis
- CV disease
- ↓ insulin sensitivity
Term
Bicalutamide (Casodex)
Definition
- Hot flashes
- gynecomastia/breast tenderness
- decreased libido
- hepatotoxicity
- elevated transaminases
- diarrhea
Term
Flutamide (Eulexin)
Definition
- Hot flashes
- gynecomastia/breast tenderness
- decreased libido
- hepatotoxicity
- elevated transaminases
- diarrhea
Term
Nilutamide (Nilandron)
Definition
- Hot flashes
- gynecomastia/breast tenderness
- decreased libido
- hepatotoxicity
- elevated transaminases
- diarrhea
Term
Aminoglutethimide
Definition
lethargy, ataxia, dizzy. Pruritic rash in 30%.
Term
Ketoconazole
Definition
GI intolerance, hypoadrenalism. Must give with hydrocortisone replacement.
Term
Carmustine
Definition
Nephrotoxicity
Myelosuppression
Pulmonary toxicity
Term
Lomustine
Definition
Nephrotoxicity
Myelosuppression
Pulmonary toxicity
Term
Streptozocin
Definition
Nephrotoxicity
Myelosuppression
Pulmonary toxicity
Term
Trastuzumab (Herceptin)
Definition
CHF
Term
Alemtuzumab (Campath)
Definition
Prolonged immunosuppression
Term
Cetuximab (Erbitux)
Definition
acne-like rash 1-3 weeks after initiation, hypersensitivity rxn
Term
Panitumumab (Vectibix)
Definition
dermatitis, rash, pruritis
Term
Bevacizumab (Avastin)
Definition
HTN, impaired wound healing, bowel perforation, thrombosis and bleeding
Term
Erlotinib
Definition
Rash, Diarrhea, interstitial lung disease
Term
Gefitinib
Definition
Rash, Diarrhea, interstitial lung disease
Term
Lapatinib (Tykerb)
Definition
CHF, hepatotoxicity, diarrhea, rash, QT prolong
Term
Dasatinib (Sprycel)
Definition
Myelosuppresson, N/V, HA, fluid retention, rash
Term
Nilotinib (Tasigna)
Definition
Empty stomach, QT prolong, myelosuppression, rash
Term
Imatinib (Gleevec)
Definition
Rash, Nausea, Fluid retention
Term
Sunitinib (Sutent)
Definition
"hand-foot reaction,
LV dysfunction, bleeding, HTN, yellow/dry/cracking skin, ↓hair pigment, 3A4 interactions"
Term
Sorafenib (Nexavar)
Definition
Rash, hand-foot syndrome
Term
Carboplatin
Definition
hemotologic toxicity, ototoxicity and vision loss @↑doses
Term
Cisplatin
Definition
"nephrotoxicity, ototoxicity, peripheral neropathy, emesis, hypersens, anemia
highly emetogenic "
Term
Oxaliplatin
Definition
cold induced neuropathy
moderately emetogenic
Term
Cyclophosphamide
Definition
- highly emetogenic
- Vesicant!
- hemorrhagic cystitis in the bladder (MESNA)
Term
Ifosfamide
Definition
- highly emetogenic
- Vesicant!
- hemorrhagic cystitis in the bladder (MESNA)
Term
Melphalan
Definition
- highly emetogenic
- Vesicant!
Term
Chlorambucil
Definition
- highly emetogenic
- Vesicant!
Term
Mechlorethamine
Definition
- highly emetogenic
- Vesicant!
Term
Intron A
Definition
- flu-like (Fever, HA, chills, myalgia, and fatigue)
- Hypotension
- Suicidal ideation
Term
Aldesleukin
Definition
capillary leak syndrome, bleeding, rigors, fever, diarrhea
Term
Diftitox
Definition
Capillary leak syndrome
Term
Thiotepa
Definition
- sweat rxns (bath often)
Term
Busulfan
Definition
pulmonary toxicity, BBW for severe bone marrow suppression, seizures: prophylaxis anticonvulsant
Term
Dacarbazine
Definition
flu like syndrome about 7 days after treatment, N/V, myelosuppression
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