Term
| Activation Energy/ Activation Barrier |
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Definition
| Amount of energy required to bring the substrate to the transition state where it forms unstable charged intermediates, undergoes bond breakage or bond formation before you have decay to product(s). |
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Term
| Magnetic Enzyme: Lock & Key Model |
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Definition
| Interaction between enzyme & substrate is fully complementary & stabilizes conformation of the substrate which lowers the energy well of the ES intermediate by stabilizing substrate. More difficult to get out of stable conformation causing activation energy to increase. |
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Term
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Definition
-charge of metal helps orient the substrate in the active site
-charge also stabilizes charged transition state intermediates |
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Term
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Definition
| Catalyzes peptide cleavage on C-side of aromatic residues Tyr, Trp, Phe |
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Term
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Definition
| Transient covalent bond is formed b/w active site of the enzyme & substrate. |
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Term
| The diffusion-controlled limit |
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Definition
10^8 M^-1sec^-1
Kcat/Km never exceeds this. An enzyme w/ a value at thisis considered to be "catalytically perfect" |
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Term
| 1st law of thermodynamics |
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Definition
| Energy is conserved but it can be transformed |
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Term
| 2nd law of thermodynamics |
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Definition
| For any event that takes place in the universe, entropy or disorder increases. |
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Term
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Definition
| Water determines how proteins fold & how lipids assemble to form membranes. |
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Term
| What happens when you put NaCl in water? |
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Definition
| NaCl in crystal form ionizes to Na+ & Cl- ions. Water will form a hydration shell around both screening out their charges to preventthem from associating w/ each other. |
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Term
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Definition
| Polar carboxylic head & non-polar hydrocarbon tail. Non-polar tails try to sequester themselves from water while heads group together to maximize exposure to water forming a micelle. |
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