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Chapters 5, 9, & 10
Exam 3
29
Science
Undergraduate 4
11/17/2011

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Term
The Human Genome
Definition
The Genetics of sex is determined by the presence or absence of the "Y" Chromosome
Term
Turner Syndrome (XO)
Definition
Normal external genitals, abnormal ovaries
Normal intelligence, abnormal spatial relations and memory
XO genotype
Random error due to mom or dad missing "X"
Term
Klinefelter Syndrome (XXY)
Definition
Reduced fertility
Social awkwardness, reduced verbal skills
May require hormone treatment to reduce female characteristics in puberty
Term
XYY
Definition
Intelligence below normal XY male
Abnormal sperm
Antisocial and criminal behavior - property
Term
Sex Chromosome Abnormalities Have Relatively Mild Effects
Definition
Nielsen and Wohlert (1991) assessed 13,000 newborns born over a 13-year period.
None with sex chromosome abnormalities were mentally retarded. All were in regular school.
No increases in criminal activity, psychological disorders or physical disorders in group with sex chromosome abnormalities.
Term
First Stage of Prenatal Development
Definition
Development of gonads - after the 6th week, the sex-determining region of the "Y" chromosome - SRY - gene is expressed in males
Term
Second stage of prenatal development
Definition
Differentiation of internal organs - fetuses contain both a Wolffian male system and a female Mullerian system. Absence of testosterone leads to development of female.
Term
Third Stage of prenatal development
Definition
External genitalia - Masculinization of male external genitalia requires stimulation by 5-alpha-dihydrotestosterone produced in the testes.
Term
Androgen Insensitivity Syndrome
Definition
A defective gene produces abnormal (insensitive) androgen receptors in an XY male fetus.
Outward appearance, brain gender and gender identity is typically female.
Typically do not know that they have a male brain
Term
Congenital Adrenal Hyperplasia (CAH)
Definition
Masculinizes female genitalia - large clitoris, etc.
Males may mature earlier
Term
5-Alpha-Reductase Deficiency
Definition
In 5-alpha-reductase deficiency, external genitalia are ambiguous, and child is raised as a female.
Internal organs are male, as unconverted testosterone is responsible for their masculinization.
Term
Digestion
Definition
Saliva is mixed with food in the mouth.
Swallowed food is mixed with acid and pepsin in the stomach.
Nutrients are absorbed from the small intestine.
Indigestible material is formed into feces in the large intestine.
Term
Carbohydrates
Definition
Broken down into simpler sugars, like glucose.
Term
Proteins
Definition
Broken down into amino acids
Term
Fats
Definition
Broken down into fatty acids
Term
Fat and Sugars
Definition
Used immediately, or stored as fat in adipose tissue for later use (Glucose can also be stored in liver when converted to glycogen)
Term
Use of Nutrients
Definition
Brain uses only glucose as its nutrient source
Other cells can use glucose or fatty acids
If blood glucose runs low, liver converts glycogen to glucose
Term
Insulin
Definition
Helps store excess glucose as glycogen
Term
Type I Diabetes
Definition
Destruction of insulin-produced cells
Glucose stays in blood, doesn't get to cells
Children
Extreme thirst, frequent urination, fatigue, weight loss
Term
Type II Diabetes
Definition
Adults
Obesity leads to insulin resistance
Can be controlled through healthy diet
Term
Hunger Cues
Definition
External - sight, smell, time, environment
Internal - stomach growling, stored fat, glucose availability
Term
Receptors and Hunger
Definition
Glucoreceptors in nucleus of solitary tract (NST)
Receives input from the taste system
Term
Brian Mechanisms for Hunger
Definition
Lateral hypothalamus
Term
Neurochemicals and Hunger
Definition
Fat cells that are full secrete leptin
Arcuate nuclear responds to leptin levels
Term
Lateral Hypothalamus and Hunger
Definition
LH lesions inhibit eating and will cause starvation
Electrical stimulation of the LH produces eating
Term
Melanin-concentrating hormone (MCH)
Definition
Communicates widely between the hypothalamus and the cortex
Term
Orexins
Definition
Released by the LH during fasting and communicate with the cortex, midbrain, and pons
Injection of orexins increases eating behavior
Term
Satiety
Definition
Stomach fullness, leptin, release of CCK (antagonizes eating)
aMSH and CART
Term
Weight Gain in VMH Syndrome
Definition
Produces weight gain and picky eating
Disrupt pathways linking PVN and NST
Excess insulin production
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