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| gene segments are reassembled which then allows expression. |
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| intracellular peptides, CD8 cytotoxic T cell. |
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| extracellular peptides, CD4 Helper T cells |
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| inactivate or block toxins or pathogens |
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| mark pathogens for destruction |
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| Receptor mediated endocytosis |
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| cells internalize molecules by inward budding of plasma membrane. |
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| Involved in direct opsonization |
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| Involved in complement mediated opsonization, binds to C3b. |
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| The first to bind out of five ab isotypes-process of switching Ab types is called isotype switching. |
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| selects for antibodies that bind more tightly to pathogens. |
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| Positive selection of T cells |
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| thymocytes selected to survive and divide |
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| Negative selection of T cells |
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| The cells that survive this leave the thymus for circulation. |
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| immunity dominated by antibodies that can be transferred to another person. |
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| fragment crystallizable, binds to immune cells. |
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| Antibody binding isotypes |
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| strand region that has reduced variability |
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| part of the antibody that contacts the antigen |
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| usually a carbohydrate or a protein |
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| part of the antigen bound by Ab |
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| strength of interaction between epitope and one antigen binding site |
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| strength of the sum of interactions between antibody and antigen |
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| immortalized cell fusion of B cell adn myeloma cell |
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| epitope recognized by its primary structure. |
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| antigen molecules with more than one identical epitope per molecule |
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| formed by parts of a protein that are separated in the amino acid sequence but brought together in a folded protein. |
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| Antibodies that recognize more than one epitope. |
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| only the Fab fragment is used or Humanized versions. |
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| the orginal unrearranged organization of the immunoglobulin T cell receptor genes in DNA of germ cells and somatic cells other than B and T cells. |
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| Recombination Signal Sequence (RSS) |
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| directs teh recombination of V, D, and J |
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| contribution of P and N nucleotides to resulting amino acid sequence diversity in third hypervariable region. |
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| splices the primary transcript RNA to generate IgD and IgM. |
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| invariant transmembrane proteins with dual function. |
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| Only one copy of the Ig locus from a B cell is allowed to successfully rearrange. |
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| Combinatorial association |
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| each functional light chain is found associated with a different functional heavy chain and vice versa. |
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| mutations introduced to the V regions |
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| mutant Ig molecules with higher affinity are more likely to bind antigen and their B cells are preferentially selected. |
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| IgM switched to other isotypes |
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| activation induced cytidine deaminase |
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| flank each C gene by Mu switching to any other isotype |
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