Shared Flashcard Set

Details

Chapters 3 and 4
N/A
51
Immunology
Professional
01/25/2011

Additional Immunology Flashcards

 


 

Cards

Term
BCR
Definition
B-cell receptor
Term
TCR
Definition
T-cell receptor
Term
Antigen-binding site
Definition
binds to molecules
Term
Germline configuration
Definition
what you inherit.
Term
Somatic recombination
Definition
gene segments are reassembled which then allows expression.
Term
MHC I
Definition
intracellular peptides, CD8 cytotoxic T cell.
Term
MHC II
Definition
extracellular peptides, CD4 Helper T cells
Term
CD8 T cells
Definition
Cytotoxic T cell
Term
CD4 T cell
Definition
helper T cells
Term
Neutralization
Definition
inactivate or block toxins or pathogens
Term
Opsonization
Definition
mark pathogens for destruction
Term
Receptor mediated endocytosis
Definition
cells internalize molecules by inward budding of plasma membrane.
Term
FC receptor
Definition
Involved in direct opsonization
Term
CR1 receptor
Definition
Involved in complement mediated opsonization, binds to C3b.
Term
IgM
Definition
The first to bind out of five ab isotypes-process of switching Ab types is called isotype switching.
Term
Isotype switching
Definition
Switching Ab types
Term
Somatic hypermutation
Definition
selects for antibodies that bind more tightly to pathogens.
Term
Clonal Selection
Definition
self-tolerance
Term
Thymocytes
Definition
immature T-cells
Term
Positive selection of T cells
Definition
thymocytes selected to survive and divide
Term
Negative selection of T cells
Definition
The cells that survive this leave the thymus for circulation.
Term
Humoral immunity
Definition
immunity dominated by antibodies that can be transferred to another person.
Term
Fab
Definition
fragment antigen binding
Term
Fc region
Definition
fragment crystallizable, binds to immune cells.
Term
Antibody binding isotypes
Definition
IgG, IgM, IgD, IgA, IgE
Term
Framework region
Definition
strand region that has reduced variability
Term
Hypervariable regions
Definition
part of the antibody that contacts the antigen
Term
Antigen
Definition
usually a carbohydrate or a protein
Term
Epitope
Definition
part of the antigen bound by Ab
Term
Affinity
Definition
strength of interaction between epitope and one antigen binding site
Term
Avidity
Definition
strength of the sum of interactions between antibody and antigen
Term
Hybridoma
Definition
immortalized cell fusion of B cell adn myeloma cell
Term
Linear epitope
Definition
epitope recognized by its primary structure.
Term
Multivalent Antigens
Definition
antigen molecules with more than one identical epitope per molecule
Term
Discontinuous epitope
Definition
formed by parts of a protein that are separated in the amino acid sequence but brought together in a folded protein.
Term
Polyclonal antibodies
Definition
Antibodies that recognize more than one epitope.
Term
Antivenin
Definition
only the Fab fragment is used or Humanized versions.
Term
Gene rearrangement
Definition
the orginal unrearranged organization of the immunoglobulin T cell receptor genes in DNA of germ cells and somatic cells other than B and T cells.
Term
Recombination Signal Sequence (RSS)
Definition
directs teh recombination of V, D, and J
Term
Junctional diversity
Definition
contribution of P and N nucleotides to resulting amino acid sequence diversity in third hypervariable region.
Term
Alternative splicing
Definition
splices the primary transcript RNA to generate IgD and IgM.
Term
IgB(beta) adn Iga(alpha)
Definition
invariant transmembrane proteins with dual function.
Term
Allelic exclusion
Definition
Only one copy of the Ig locus from a B cell is allowed to successfully rearrange.
Term
Combinatorial association
Definition
each functional light chain is found associated with a different functional heavy chain and vice versa.
Term
Membrane coding
Definition
transmembrane IgM
Term
Secretion coding
Definition
secreted IgM
Term
Somatic Hypermutation
Definition
mutations introduced to the V regions
Term
affinity maturation
Definition
mutant Ig molecules with higher affinity are more likely to bind antigen and their B cells are preferentially selected.
Term
Isotype switching
Definition
IgM switched to other isotypes
Term
AID
Definition
activation induced cytidine deaminase
Term
Switch region
Definition
flank each C gene by Mu switching to any other isotype
Supporting users have an ad free experience!