Term
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Definition
| MS - Chronic neurologic disorder characterized by targeted destruction of CNS myelin as well as axonal degeneration and loss |
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Term
| What are the two phases of MS? |
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Definition
Initial focal inflammatory phase
followed by degenerative phase with inflammation that is more diffuse |
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Term
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Definition
| injection site reactions and flu-like symptoms. Rare reaction: hepatotoxicity |
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Term
| What are the first line agents in MS ? |
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Definition
| Interferon Beta or glatiramer |
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Term
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Definition
If RRMS (relapsing remitting MS) and patient is not breastfeeding or wishing to become pregnant, take either interferon beta or glatiramer.
If response is insufficient or not well tolerated, switch to the other of the aforementioned agents.
If response is insufficient or drug is not tolerated switch to either: fingolimod, mitoxantrone, or natalizumab |
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Term
| Side Effects of Glatiramer Acetate |
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Definition
Glatiramer
Injection site reactions, chest tightness, flushing |
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Term
| Place in MS therapy, and side effects |
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Definition
Place in MS therapy - 3rd line, after failed interferon beta and glatiramer
SEs: cardiotoxicity, Leukemia |
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Term
| Natalizumab: Place in therapy & Side effects |
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Definition
Place in MS therapy - 3rd line, after failed interferon beta and glatiramer
SEs: Hypersensitivity rxns, Progressive Multifocal leukoencephalopathy (PML) --> risk worsens with other immunomodulating drugs. |
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Term
| Fingolimod: Place in MS therapy & SEs |
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Definition
Fingolimod: Place in MS therapy - 3rd line, after failed interferon beta and glatiramer
SEs: Well tolerated |
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Term
| MS in pregnancy and breastfeeding |
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Definition
| Tends to have a period of decreased progression likely as a result of immune changes for the fetus. Relapse rate is high postpartum. Clinicians favor cessation of treatment during both pregnancy & breastfeeding. |
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Term
| MS and preconception, recommendations to both men and women? |
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Definition
| Recommend that immunomudulators are D/Ced for 1-3 months priod to conception |
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