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Chapter 9
Adrenergic Pharm
70
Pharmacology
Graduate
09/18/2012

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Term
Alpha-methyltyrosine
Definition
inhibits tyrosine hydroxylase
Term
Alpha-methyltyrosine
Definition
TX: pheochromocytoma
Term
Alpha-methyltyrosine
Definition
AE: orthostatic hypertension and sedation *RARELY USED*
Term
Reserpine
Definition
blocks uptake NE/D thru VMAT channels
Term
Reserpine
Definition
TX: Hypertension, experimentally used
Term
Reserpine
Definition
AE: arrhythmia, psychoitc depression, nasal congestion, dizziness, TCP
Term
Guanethidine
Definition
concentrates in vessels and displaces NE/D
Term
Guanadrel
Definition
concentrates in vessels and displaces NE/D
Term
Guanethidine/Guanadrel
Definition
TX: Hypertension
Term
Guanethidine/Guanadrel
Definition
AE: inhibits cardiac nerves and leads to hypotension during exercise, Kidney disease, apnea
Term
Amphetamine
Definition
blocks reuptake of by NET, DAT, inhibit MAO, and displace transmitters from vesicles
Term
Amphetamine
Definition
TX: ADHD, Narcolepsy
Term
Amphetamine
Definition
AE: hypertension, Tourettes, seizures, psychosis, fatigue, loss of appetite, addiction
Term
Methylphenidate
Definition
same as amphetamine
Term
Pseudoephedrine
Definition
TX: Allergic rhinitis, nasal congestion
Term
Pseudoephedrine
Definition
releases stored catecholamines
Term
Pseudoephedrine
Definition
AE:A fib, ischemia, hypertension, tachycardia, rebound congestion
Term
Cocaine
Definition
inhibits NET reuptake of catecholamines
Term
Imipramine
Definition
inhibits NET reuptake of catecholamines
Term
Amitriptyline
Definition
inhibits NET reuptake of catecholamines
Term
MAOI's- Phenelzine, Iproniazid
Definition
inhibit degradation of catecholamines
Term
MAOI's- Phenelzine, Iproniazid
Definition
Tx: Depression
Term
Methoxamine
Definition
a1 agonist
Term
Methoxamine
Definition
TX: hypotension, shock
Term
Methoxamine
Definition
AE: hypertension, bardycardia mediated vagal reflux,
Term
Phenylephrine
Definition
A-1 agonist
Term
Oxymetazoline
Definition
A-1 agonist
Term
Tetrahydrozoline
Definition
A-1 agonist
Term
Phenylephrine
Definition
TX: Shock thru IV
Term
Tetrahydrozoline, Oxymetazoline
Definition
Visine and Afrin Trade names
Term
Tetrahydrozoline, Oxymetazoline
Definition
Opthalmic hyperemia, nasal congestion
Term
Tetrahydrozoline, Oxymetazoline, Phenylephrine
Definition
AE: arrhythmia, hypertension, headache, rebound congestion
Term
Clonidine
Definition
A-2 agonist inhibiting sympathetic outflow from CNS
Term
Methyldopa
Definition
A-2 agonist inhibiting sympathetic outflow from CNS
Term
Guanabenz, Guanfacine
Definition
A-2 Agonist inhibiting sympathetic outflow from CNS
Term
Clonidine
Definition
TX: opoid withdrawl, cancer pain, hypertension with renal disease
Term
Methyldopa
Definition
Treatment of Hypertension during pregnancy
Term
Methyldopa
Definition
AE: hepatotoxicity, AI hemolytic anemia, and DO NOT USE WITH MAOI
Term
Metaproterenol, Albuterol, Salmeterol, terbutaline
Definition
B-agonists
Term
Metaproterenol and Albuterol
Definition
TX: acute Asthma
Term
Salmeterol
Definition
TX: long term asthma treatment and COPD
Term
Terbutaline
Definition
Reduce premature uterine contractions
Term
Phenoxybenzamine
Definition
A-1/2 irreversible antagonist
Term
Phentolamine
Definition
A-1/2 reversible antagonist
Term
Phentolamine, Phenoxybenzamine
Definition
TX: Pheochromocytoma leading to hypertension
Term
Phentolamine, Phenoxybenzamine
Definition
AE: hypotension, lack of ejaculation, dry eyes, seizures
Term
Phentolamine
Definition
used in patients with MAO'I's who eat foods with large amounts of tyramine containing foods which lead to displaced NE and hypertension
Term
Prazosin, Terazosinm Doxazosin
Definition
A1 antagonists
Term
Prazosin, Terazosinm Doxazosin
Definition
TX: BPH and hypertension
Term
Tamsulosine
Definition
BPH
Term
Tamsulosine
Definition
A1 antagonist of GU smooth muscle
Term
Prazosin, Terazosin, Doxazosin
Definition
AE: Pancreatitis, hepatotoxic, SLE, postural hypotension with first dose
Term
Yohimbine
Definition
A-2 antagonist which leads to increased NE, and increased B1 receptors and peripheral vascular receptors
Term
Yohimbine
Definition
Psychological impotence
Term
Propranolol, Nadolol, Timolol
Definition
B1 and B2 blockers
Term
Propranolol, Nadolol, Timolol
Definition
Hypertension, Angina, MI, CHF
Term
Timolol, levobunolol and carteolol
Definition
Glaucoma
Term
Beta blockers
Definition
AE: impotence, asthma, bradycardia, AV block, decreased libido
Term
Labetalol, Carvedilol
Definition
block a1 b1 and b2 receptors
Term
Labetalol, Carvedilol
Definition
TX: angina hypertension
Term
Labetalol, Carvedilol
Definition
AE: same as Betablockers but Hepatotoxic as well
Term
Pindolol, Acebutol
Definition
partial b agonists (1st both b1/b2, 2nd only b2)
Term
Atenolol, metoprolol, esmolol (short), betaxolol
Definition
B1 antagonists
Term
Atenolol, metoprolol, esmolol (short), betaxolol
Definition
Tx: hypertension, angina, heart failure
Term
esmolol
Definition
Tx: thyroid storm
Term
a-1
Definition
increase SM contraction, GU contraction,
Term
a-2
Definition
inhibits sympathetic release in CNS, decreased insulin release, platelets aggregate
Term
b-1
Definition
increase heart rate, strength, AV conduction
increases renin release
Term
b-2
Definition
relaxes smooth muscle, glycogen breakdown and glucose release
Term
b-3
Definition
fat lipolysis
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