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Definition
| Immunoreceptor tyrosine-based activation motifs. Involved in B cell signaling. |
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Definition
| A tyrosine kinase involved in B cell signaling. Binds to phosphorylated ITAMs. |
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Definition
| Involved in transmitting signals. Consists of a a complement receptor 2 (which binds iC3b adn C3d), CD19-signaling function, CD81-unknown function. |
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Definition
| Thymus deficient patients or mice can generate antibodies to some antigen. Results in direct activation of B cell. |
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Definition
| Thymus Independent antigen that involves other receptors. |
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Term
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Definition
| Thymus independent antigens that involve a repetitive epitope. |
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Definition
| Cell interaction that is specific for the same antigen. |
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Definition
| strengthen cognate interactions. |
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Definition
| Stromal cells derived from fibroblast-like cells-NOT hematopoietic cells. Functions include helping the B cell mature and storage of antigen in iccosomes. |
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Definition
| bundles of antigen present on dendrites of the FDCs. |
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Definition
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Definition
| encourages memory B cell formation. |
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Definition
| different from primary focus to secondary focus. |
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Definition
| First antibody produced and activates the classical complement pathway. |
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Term
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Definition
| Important for dealing with blood-borne infections. Small size. |
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Definition
| Helps in blood-borne infections. Small size. |
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Definition
| an Fc receptor that transports IgG across epithelial and has a structure resembling an MHC Class I molecule. |
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Term
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Definition
| Protects mucosal surfaces, prevents attachment and colonization, made in lamina propria. |
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Definition
| Involved with dimeric IgA, binds to IgA and IgM via J chains. |
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Term
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Definition
| How poly-IG receptors bind to IgA and IgM. |
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Term
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Definition
| The transport of molecules from one side of an epithelium to the other by endocytosis into vesicles within the epithelial cells at one face of the epithelium and release of the vesicles at the other. |
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Definition
| rapid ejection of pathogens, activates mast cells to release mediators to act on smooth muscle. |
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Definition
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Definition
| Transfer of immunity to a non-immune individual by the injection of specific antibody, immun serum, or T cells. |
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Definition
| glycoprotein of the influenza virus coat that binds to certain carbs on human cells, the first step in infection of cells with the virus. Changes in the hemagglutinin are the major source of antigenic shift. The protein is called a hemagglutinin because it can aggglutinate red blood cells. |
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Term
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Definition
| Part of Strep. pyogenes that binds to glycoproteins on pharynx cells (bacterial adhesion) |
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Term
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Definition
| Activates adenylate cyclase, elevates cAMP in cells, leading to changes in intestinal epithelial cells that cause loss of water and electrolytes. |
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Definition
| toxins that have been deliberately inactivated by heat or chemical treatment so that they are no longer toxic but can still provoke a protective immune response on vaccination. |
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Term
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Definition
| Fc of each IgM monomer binds to C1q (involved in IgM activation of complement) |
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Term
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Definition
| a.k.a. C2aC4b, formed when C1 intiates protease cascade resulting in deposition of C4b (involved in IgM activation of complement) |
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Term
| Alternative C3 convertase |
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Definition
| a.k.a. C3bBb, formed when C3b is deposited on surface (involved in IgM activation of complement) |
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Term
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Definition
| helps form the alternative C3 convertase (part of IgM activation of complement) |
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Term
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Definition
| transported to spleen and liver by RBCs and are selectively removed by macrophages. |
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Term
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Definition
| patients have massive deposition of immune complexes in the kidney which results in tissue damage and kidney failure. |
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Term
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Definition
| cells that bind immune complexes and eventually remove them. |
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Term
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Definition
| preferential attack of thioester bond by amino group, deficiency associated with lupus |
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Term
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Definition
| preferential atack of thioester bond by hydroxyl group. (Deficiency associated with increased infections) |
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Term
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Definition
| Hinge region, IgG1, IgG2, IgG3, IgG4 |
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Term
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Definition
| affects the flexibility of an IgG and determines its subclass. |
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Term
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Definition
| "all rounder", has intermediate flexibility, protease susceptibility, complement activation |
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Term
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Definition
| several disulfide bonds on a short hinge-less flexible but more stable adn optimal for binding to repetitive carb antigens. |
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Term
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Definition
| long hinge-superior activation of complement. |
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Definition
| does not bind to complement, has anti-inflammatory properties. |
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Definition
| A chronic inflammatory disorder of the gastrointestinal tract. |
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Definition
| facilitates phagocytosis. |
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Definition
| is resistant to direct phagocytosis so IgG-mediated phagocytosis is important. |
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Term
| Fc(gamma)RII and Fc(gamma)RIII |
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Definition
| low affinity receptors, requires multiple attachment points. |
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Term
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Definition
| Antibody-dependent cell-mediated cytotoxicity. |
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Definition
| Expressed on mast cells, basophils and eosinophils. |
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Term
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Definition
| Increases local blood vessel permeability. |
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