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Chapter 9 Golan Fall 2010 Adrenergic Pharmacology
Adrenoceptors and Catecholamine neurotransmitters (Norepinephrine, Epinephrine, Dopamine)
16
Pharmacology
Professional
09/30/2010

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Term
moiety
Definition
a part or functional group of a molecule
Term
catecholamines
Definition
-part of sympathetic nervous system
-water soluble and bound to plasma protein (circ in the blood)
-NE, E, Dopamine
Term
MAO
Definition
monoamine oxidase is one of the enzymes responsible for catecholamine degradation
Term
GRK
Definition
G protein receptor kinase
Term
DOPA
Definition
dihdroxphenylalanine (from oxidation of tyrosine by enzyme tyrosine hydroxylase)
Term
VMAT
Definition
vesicular monoamine transporter
Term
NET
Definition
NE transporter reuptake to neuron
Term
location of adrenergic receptors (adrenoceptors)
Definition
presynaptic and postsynaptic neurons
Term
sympatholytic
Definition
inhibitor of sympathetic activity
Term
adynylate cyclase
Definition
-catalyzes the conversion of ATP to cAMP and pyrophosphate
-(AC) is a lyase enzyme, part of the cAMP-dependent pathway
Term
DAT
Definition
Dopamine transporter reuptake to neuron
Term
COPD
Definition
Chronic obstructive pulmonary disease
Term
gluconeogenesis
Definition
generation of glucose from non-carbohydrate carbon substrate such as lactate, glycerol, and glucogenic amino acid
Term
glycogenolysis
Definition
aka glycolysis: catalyze glycogen to glucose
Term
What happens to the heart when beta1 receptor stimulated? (adrenergic)
What happens to the heart when mAChR M2 stimulated? (cholinergic)
Definition
Adrenergically, the heart increases rate and force (sympathetic) via Gs mechanism
Cholinergically, the heart's slow (parasympathetic) via Gi
Term
What happens to the lungs when beta2 receptor stimulated? (adrenergic)
What happens to the lungs when mAChR M3 stimulated? (cholinergic)
Definition
Adrenergically, the lungs relax (broncodilation) via
Cholinergically, the lungs contract (bronchoconstriction) via Gq/11 mechanism
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