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Chapter 8: An Introduction to Metabolism
Berrett: AP Bio
30
Biology
12th Grade
11/01/2012

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Term
1st law of thermodynamics
Definition
Conservation of energy: energy can be transferred and transformed, but it cannot be created or destroyed.
Term
2nd law of thermodynamics
Definition
The principle stating that every energy transfer or transformation increases the entropy of the universe.
Term
Activation Energy
Definition
The amount of energy that reactants must absorb before a chemical reaction will start
Term
Active site
Definition
The specific portion of an enzyme that binds the substrate by means of multiple weak interactions and that forms the pocket in which catalysis occurs.
Term
Allosteric regulation
Definition
The binding of a regulatory molecule to a protein at one site that affects the function of the protein at a different site.
Term
Anabolic pathway
Definition
A metabolic pathway that consumes energy to synthesize a complex molecule from simple molecules.
Term
catabolic pathway
Definition
A metabolic pathway that releases energy by breaking down a complex molecules into simpler compounds
Term
catalyst
Definition
A chemical agent that increases the rate of a reaction without being consumed by the reaction.
Term
chemical energy
Definition
A form of potential energy that is stored in molecules, ready for release in a chemical reaction.
Term
coenzyme
Definition
An organic molecule serving as a cofactor. Example: Vitamins.
Term
cofactor
Definition
Any nonprotein molecule or ion that is required for the proper functioning of an enzyme. They may be permanently bound to the active site of may bind loosely with the substrate during catalysis.
Term
competitive inhibitor
Definition
A substance that reduces the activity of an enzyme by entering the active site in place of the substrate whose structure it mimics.
Term
cooperativity
Definition
A type of allosteric regulation whereby a shape change in one subunit of a protein caused by substrate binding is transmitted to all the others, facilitating binding of subsequent substrate molecules.
Term
endergonic reaction
Definition
A non-spontaneous chemical reaction, in which free energy is absorbed from the surroundings.
Term
energy
Definition
The capacity to cause change, especially to do work (to move matter against an opposing force).
Term
energy coupling
Definition
In cellular metabolism, the use of energy released from an exergonic reaction to drive an endergonic reaction.
Term
enzyme
Definition
A macromolecule serving as a catalyst.
Term
exergonic reaction
Definition
A spontaneous chemical reaction, in which there is a net release of free energy.
Term
feedback inhibition
Definition
A method of metabolic control in which the end product of a metabolic pathway acts as an inhibitor of an enzyme within that pathway.
Term
free energy
Definition
The portion of a biological system's energy that can perform work when temperature and pressure are uniform throughout the system.
Term
heat
Definition
The total amount of kinetic energy due to the random motion of molecules in a body of matter.
Term
induced fit
Definition
The change in shape of the enzyme resulting in a more snug fit of the substrates. The change in shape is caused by the entry of the substrate into the active site.
Term
kinetic energy
Definition
The energy associated with the relative motion of objects.
Term
metabolic pathway
Definition
A series of chemical reactions that either builds a complex molecule or breaks down a complex molecule into simpler compounds.
Term
metabolism
Definition
All of the chemical reactions of an organism, including catabolic and anaboli pathways.
Term
non-competitive inhibitor
Definition
A substance that reduces the activity of an enzyme by binding to a location different than the active site, resulting in a change to the enzyme's shape.
Term
phosphorylated
Definition
A molecule that is chemically bonded to a phosphate group.
Term
potential energy
Definition
The energy that matter possesses as a result of it location or spatial arrangement.
Term
substrate
Definition
The reactant on which an enzyme works.
Term
thermal energy
Definition
heat
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