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Chapter 8
Nucleotides & Nucleic Acids
13
Biochemistry
Undergraduate 3
02/08/2016

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Term
gene
Definition
a segment of a DNA molecule that contains the information required for the synthesis of a functional biological product (either protein or RNA)
Term
messenger RNAs (mRNAs)
Definition
intermediaries that carry genetic information from one or a few genes to a ribosome where the corresponding proteins can be synthesize
Term
transfer RNAs (tRNAs)
Definition
adapter molecules that translate the information in mRNA into a specific sequence of amino acids
Term
3 characteristic components of a nucleic acid
Definition
1. a nitrogenous base
2. a pentose
3. one or more phosphates
Term
2 parent compounds for the nitrogenous bases of nucleic acids
Definition
1. pyrimidine
2. purine
Term
2 major purine bases in DNA & RNA
Definition
1. adenine
2. guanine
Term
What is the difference between the pyrimidine bases of DNA & the pyrimidine bases of RNA?
Definition
DNA = cytosine & thymine

RNA = cytosine & uracil
Term
What is the difference between deoxyribonucleotides & ribonucleotides?
Definition
deoxyribonucleotides = the structural units of DNAs

ribonucleotides = the structural units of RNAs
Term
phosphodiester linkage
Definition
the 5'-phosphate group of one nucleotide unit is joined to the 3'-hydroxyl group of the next nucleotide; the phosphate-group "bridges" that covalently link the successive nucleotides of both DNA & RNA
Term
What is the difference between the 5' end & the 3' end?
Definition
5' end = lacks a nucleotide at the 5' position

3' end = lacks a nucleotide at the 3' position
Term
oligonucleotide
Definition
a short nucleic acid
Term
polynucleotide
Definition
a long nucleic acid
Term
Where are nucleotide-binding fold domains found?
Definition
in enzymes that bind ATP & nucleotide cofactors
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