• inhibit prostaglandin synthesis in CNS and peripheral nervous system

1. Cox-1 (nonselective)
2. Cox-2 : GI tract  (both selective and nonselective)

• prevention and treatment of mild to moderate pain and inflammation associated with musculoskeletal disorders
• relieve pain
• reduce fever
• suppress platelet aggregation

What are some contraindications to using Analgesic-antipyretic-anti-inflammatorys?

• peptic ulcer disease, GI or other bleeding disorders, impaired renal function
• black box warning: increased risk of serious cardiovascular thrombotic events, MI, and stroke with use of selective and nonselective NSAIDS

• prototype of analgesic- antipyretic-anti-inflammatory drugs
• most commonly used salicylates
• available OTC (over the counter) many therapeutic effects: pain, fever, OA, RA, prophylaxix of MI, TIA, and strokes in men, rheumatic fever

• p)ropionic acid derivatives: ibuprofen (motrin, advil) and naproxen (naprosyn)
• Acetic acid derivatives : indomethacin (indocin) good anti-inflamamatory

• Related Drugs: ketorolac (Toradol)--> IV last 8 hrs; high risk for bleeding; can only last for 5 days then take a break for 3 days

Celeboxib (Celebrex)--> arthritis related pain;

• Equal to aspirin in analgesic and antipyretic effects, Lacks anti-inflammatory properties
• does not cause N/V, GI bleeding, or interfere with blood clotting like aspisrin does
• is tolerated better than NSAIDS

• prevents formation of uric acid
• used to treat or prevent gout and used with antineoplastic drug therapy

• Anti-inflammatory used to prevent or treat attacks of gout
• reduces inflammation, has no direct analgesic or antipyretic effects

• limited to 7 days of therapy
• bc toxic to bone marrow

• GI side effects are common
• N/V, severe diarrhea, and abdominal pain