Term
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Definition
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Term
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Definition
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Term
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Definition
| increase in cell number, in cells capable of mitosis |
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Term
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Definition
conversion of one cell type to another, stays w/I primary tissue type
*allows for substitution of cells to better survive circumstances |
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Term
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Definition
| non-adaptive, deranged cell growth that results in cells varying in shape, size, and organization (pleomorphism) |
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Term
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Definition
| overgrowth of tissue, irreversible in a cells growth pattern, autonomous |
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Term
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Definition
| do not metastasize, growth is slow and orderly, tumor localized |
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Term
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Definition
| rapid, aggressive, metastasize |
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Term
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Definition
| pattern of change that reflects and earlier cell, degree is related to malignancy |
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Term
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Definition
| connective tissue framework, tissue not neoplastic. malignant tumors secrete factors that stimulate fibroblasts to produce collagen |
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Term
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Definition
| blood vessels, newly formed tumor capillaries have looser endothelial junctions and lack basement membrane=more permeable |
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Term
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Definition
| normal size/shape, tissue proceeds in orderly pattern |
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Term
| Malignant characteristics |
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Definition
| pleomorphic, configuration is disordered, metastasis, invasive |
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Term
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Definition
| genetic damage, no stopping, |
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Term
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Definition
proteins that indirectly regulate mitosis, DNA repair and apoptosis
defective known as "oncogenes" |
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Term
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Definition
| implicated in many tumors due to p53 gene |
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Term
| Factors of tumor invasion |
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Definition
-reduced intercellular adhesion
-acquisition of surface receptors enable them to bind to basement membrane
-chemotaxis |
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Term
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Definition
| difficult to effect a cur, invasion and metastasis not linked |
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Term
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Definition
| carried to secondary sites by lymph or blood |
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Term
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Definition
| thin walls of capillaries/veins allow easy penetration |
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Term
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Definition
growth favored w/I lymph node b/c:
-tumor tissue becomes source of new emboli
-tumor growth in lymph node blocks normal flow
-metastasis favored b/c vascular arrangement of lymph node |
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Term
| Metastasis via body cavities |
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Definition
| tumors invade through surface of primary site organ and spread |
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Term
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Definition
| during surgical excision, tumor spreads |
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Term
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Definition
| tumor expands and puts pressure on normal cells |
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Term
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Definition
| CNA vulnerable due to close cavities |
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Term
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Definition
| obstructing duct or other passage interfers with normal flow |
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Term
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Definition
| wasting disease, general weakness |
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Term
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Definition
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Term
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Definition
| tumor replaces functional tissue and red cell production falls |
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Term
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Definition
| tumors of nonendocrin origin develop ability to secret functional hormones |
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Term
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Definition
| surgery, radiation, chemo, combination |
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Term
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Definition
T: size of tumor
N: degree of regional lymph node
M: tumor metastasis |
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Term
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Definition
| because they trap emboli arising in primary tumor sites |
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Term
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Definition
| due to hepatic portal system |
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Term
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Definition
| arising in ectodermal or endodermal tissue |
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Term
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Definition
| arising in mesodermal tissue |
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Term
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Definition
| anaerobic metabolism, lose specialized functional capabilities |
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Term
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Definition
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Term
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Definition
| overproduction of mucus to loose gelatinous tumor |
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Term
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Definition
| toxic used to destory tumor, damaging DNA, not able to selectively damage tumor cells |
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