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chapter 5 new
integumentary system
39
Biology
Undergraduate 2
02/10/2012

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Term
Epidermis:
Definition
- made up of keratinized stratified squamous epithelium
Term
Keratinocytes
Definition
- produce the water insoluble protein keratin whichhardens structures
- Approx. 90% of Epidermal cells
Term
Melanocytes
Definition
- produce melanin, a brown/black pigment which absorbs UVlight and is the primary skin pigment
- Approx. 8% of Epidermal cells
Term
Langerhans cells
Definition
- produced in the bone marrow
- help provide immunity to the epidermis
Term
Merkel cell (disc)
Definition
- nerve ending for touch
Term
Stratum Basale
Definition
- a single layer of cuboidal shaped cells
- mitotically active
Term
Stratum Spinosum
Definition
- 8 to 10 cell layers thick
- cells start to flatten as they reach the upper part ofthis layer
Term
Stratum Granulosum
Definition
- 3 to 5 cell layers thick
- cells continue to flatten out
- cells begin to die forming a water resistant barrier,i.e. keratinization
Term
Stratum Lucidum
Definition
- only present on the finger tips, palms and soles of thefeet
- 3 to 5 layers of cells
Term
Stratum Corneum
Definition
- 20 to 30 cell layers in thickness
- flattened dead keratinocytes, no nuclei
- outer layers are continually shed needing to bereplaced
- Approx. 3/4 of the epidermal thickness
Term
Dermis
Definition
- mostly connective tissue containing collagen & elastinfibers, few cells
- two regions (layers):
Term
Papillary Region:
Definition
- superficial portion
- Dermal Papillae = tiny projections into the epidermis whichincrease the surface area of the Stratum Basale
- Meissner corpuscles (corpuscles of touch) = tactilereceptors located at the apex of Dermal Papillae
- Epidermal Ridges = Dermatoglyphs = Finger prints
assoc. with the underlying papillae
Term
Reticular Region:
Definition
- deepest and largest portion
- contains irregular C.T.
Term
Hypodermis
Definition
- composed of Adipose and Areolar C.T.
- stores fat
- contains vessels and nerves that supply the skin
Term
Melanin
Definition
- brown/black pigment produced from Melanocytes
- made from amino acid Tyrosine (Tyrosinase)
- disorders: Albinism, Vitiligo
Term
Carotene
Definition
- a yellow/orange pigment; not assoc. with jaundice
- assoc. with vitamin A
Term
Hemoglobin
Definition
- pink/red pigment
- the oxygen carrying molecule in RBCs
- assoc. with translucent skin (i.e. skin lacking melanin)
Term
Hair = Pili
Definition
- covers most skin surfaces
- columns of dead keratinized cells that are bonded together
- protects the body from heat loss and UV light
Term
- Shaft
- Root
- Follicle
Definition
= portion of the hair above the surface of the skin
= portion of the hair below the surface
= tissue that surrounds the root of the skin
Term
Nails
Definition
- plates of tightly packed, keratinized epidermal cells
Term
Sebaceous Glands
Definition
- secrete sebum, an oily substance that softens and lubricatesthe skin, water proofing, maintains hair follicles,contains antibacterial substances
- associated with hair follicles, lips, pubic region
- not found on palms and soles
Term
Sudoriferous (Sweat) Glands
Definition
- release secretions onto the surface of the skin
Term
Eccrine gland
Definition
- most common
- produces watery sweat that contains ions and small organicmolecules
- help regulate body temperature, eliminate wastes
Term
Apocrine gland
Definition
- common to axilla and groin
- watery secretion, more viscous than normal sweat, containsproteins and lipids
- secondary sexual function
Term
Epidermal
Definition
- when only the Epidermis is damaged
- the cells surrounding the wound enlarge and migrate to fillthe gap created by the injury
- mitosis in the Stratum Basale is stimulated, more cells arereproduced to make up for dead cells
Term
- Contact Inhibition =
Definition
migration ceases when the cells on bothsides of the wound come into contact
Term
Inflammatory Phase
Definition
- clot forms over wound
- local vasodilation, leukocytes (to fight infection) andfibroblasts (rebuild tissue) move into the damaged area
Term
Migratory Phase
Definition
- scab forms
- granulation (scar) tissue is laid down beneath the scab
- vessels begin to regrow
Term
Proliferative Phase
Definition
- epithelial tissues begin to mature
- collagen is laid down randomly
Term
Maturation Phase
Definition
- the scab falls off after the epidermis is restored
- circulation is restored
- fibroblasts decrease in number
Term
Fibrosis =
Definition
The process of scar tissue formation. Scar tissue isnot as healthy as the original tissue.
Term
Keloid =
Definition
Uncontrolled fibrosis. Contact inhibition does not occurso the scar tissue does not stay with in the boundary ofthe wound.
Term
Effects of Aging:
Definition
- collagen and elastin fibers stiffen and lose elasticity
- decreased activity of sweat and sebaceous glands
- subcutaneous fat decreases
Term
Basal cell carcinoma -
Definition
most common, arises from cells ofstratum basale, rarely metastasizes
Term
Malignant melanoma
Definition
- fairly rare but has high metastasis rate,
cancer of the melanocyte
Term
Risk factors
Definition
- skin type, amount of sun exposure, family history, age,immune status
Term
Burns
Definition
- tissue damage caused by excessive heat, radioactivity, orchemicals that denature proteins in skin cell
Term
First degree
Definition
- only the epidermis is damaged
Term
Second degree
Definition
- damage goes through the epidermis and into the dermis
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