Term
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Definition
Mech: Decrease bone resorption by osteoclasts
APP: Osteoporosis |
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Term
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Definition
Mech: Estrogen receptor agonist in bone and receptor antagonist in endometrium and breast (SERM)
APP: Osteoporosis
AE: Retinal vascular occlusion, venous thromboembolism, hot flashes and leg cramps
CI: Pregnancy and history of of DVT
TC: Decreases breast cancer incidence |
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Term
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Definition
Mech: Decrease bone resorption by osteoclasts
APP: Osteoporosis, Osteolytic lesions of multiple myeloma and breast cancer, Hypercalcemia associated with malignancy, Paget's disease
AE: Jaw osteonecrosis in cancer patients, Gastroesophageal pain
CI: INABILITY TO SIT UP FOR 30 MINUTES AFTER DRUG ORALLY, hypocalcemia, Esophageal disease, delayed gastric emptying
TC: Extended skeletal effects, Unclear how to define overdose |
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Term
| Alendronate and Risendronate |
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Definition
Bisphosphonate
APP: Osteoporosis and Paget's disease |
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Term
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Definition
Bisphosphonate
APP: Osteoporosis |
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Term
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Definition
Bisphosphonate
APP: OSTEOPOROSIS , Osteolytic lesions of multiple myeloma, Hypercalcemia associated with malignancy, Paget's disease
TC: IV ONLY; CAN FIX HYPERCALCEMIA IN DAYS |
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Term
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Definition
Bisphosphonate
APP: Osteolytic lesions of multiple myeloma, Hypercalcemia associated with malignancy, and Paget's disease
TC: IV ONLY; CORRECTS HYPERCALCEMIA INDAYS |
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Term
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Definition
Mech: RANKL ANTAGONIST
APP: Osteoporosis, Osteolytic lesions of multiple myeloma
AE: Jaw osteonecrosis, Hypocalcemia
CI: Hypocalcemia
TC: INJECTED SUBCUTANEOUSLY EVERY 6 MONTHS FOR OSTEOPOROSIS OR MONTHLY FOR MALIGNANCY |
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Term
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Definition
Mech: Inhibits osteoclasts, causes apoptosis or senescence
APP: Hypercalcemia
CI: Flushing, nausea, diarrhea
CI: Salmon allergy
TC: Nasal spray or subcutaneous (faster acting) |
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Term
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Definition
Mech: Increase bone formation through osteoblasts
APP: SEVERE OSTEOPOROSIS and Osteoporosis
AE: Leg cramps or Hypercalcemia or nausea and headache, or Appendicular fractures and osteomyelitis
CI: Open epiphyses, prior radiation therapy, Paget's disease, hypercalcemia and/or renal insufficiency (Fluoride)
TC: Possible long-term osteosclerosis and osteosarcomas |
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Term
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Definition
Bone Anabolic agents
APP: Severe osteoporosis, idiopathic and hypogonadal osteoporosis in men, and glucocorticoid-induced osteoporosis
AE: Leg cramps |
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Term
| hPTH1-84 (investigational) |
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Definition
Bone Anabolic Agents
APP: Severe osteoporosis
AE: Hypercalcemia, leg cramps, nausea, and headache |
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Term
| Fluoride (investigational) |
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Definition
Bone Anabolic Agents
APP: Osteoporosis
AE: Appendicular fractures and osteomalacia |
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Term
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Definition
Mech: Decrease GI absorption of inorganic phosphate
APP: Chronic kidney disease, Tumor calcinosis, and Hyperphosphatemia-hyperostosis syndrome |
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Term
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Definition
Oral Phosphate Binders
APP: Refractory hyperphosphatemia
TC: AE MAKE IT RARELY USED |
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Term
| Calcium Carbonate and Calcium Acetate |
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Definition
Oral Phosphate Binders
APP: Chronic kidney disease, Tumor calcinosis, and Hyperphosphatemia-hyperostosis syndrome
AE: Renal calculi, hypercalcemia, constipation
CI: Hyper calcemia and hypercalciuria
TC: MUST TAKE WITH FOOD |
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Term
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Definition
Oral Phosphate Binders
APP: Chronic kidney disease, Tumor calcinosis, and Hyperphosphatemia-hyperostosis syndrome
AE: Thrombosis, hypertension, constipation
CI: Bowel obstruction and hypophosphatemia
TC: LOWERS SERUM CHOLESTEROL BY BINDING BILE SALTS |
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Term
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Definition
Mech: Increase GI absorption of Calcium, decrease PTH transcription
APP: Secondary Hyperthyroidism, Hypoparathyroidism, Rickets, Osteomalacia, Osteoporosis
AE: Hypercalcemia, Renal Calculi,
CI: Renal calculi, hypercalcemia, and hyper calciuria |
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Term
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Definition
Vitamin D Analogue
TC: May cause more hypercalcemia than the other main analogues |
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Term
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Definition
Vitamin D Analogue
AE: Hypercalcemia, Renal Calculi, and EDEMA |
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Term
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Definition
Vitamin D Analogue
AE: Causes less hypercalcemia than calcitriol |
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Term
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Definition
Mech: INCREASES SENSITIVITY OF CALCIUM SENSING RECEPTORS TO CALCIUM IN PRARTHYROID (decreases PTH)
APP: Chronic kidney disease/secondary hyperparathyroidism, and Hypercalcemia associated with parathyroid carcinoma |
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Term
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Definition
Mech: Supplement
APP: Secondary hyperparathyroidism, Hypoparathyroidism, Rickets, Osteomalacia
AE: Hypercalcemia, Renal calculi, constipation, and hypercalciuria
CI: Hypercalcemia and hypercalciuria
TC: NOT FOR OSTEOPOROSIS |
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Term
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Definition
Calcium Supplement
TC: IV ONLY; less toxic than CaCl2 |
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Term
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Definition
Calcium supplement
TC: Must be taken with food
TC: Inexpensive |
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Term
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Definition
Calcium supplement
TC: Most readily absorbed form |
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Term
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Definition
Mech: Inorganic phosphate supplement
APP: Severe hypophosphatemia
AE: Diarrhea
CI: Hyperkalemia, Hyper phosphatemia, Hypocalcemia
TC: PREFERRED OVER NaPO4 to minimize renal excretion or potassium and CORRECTS HYPOKALEMIA |
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