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Chapter 22
Microbial diseases of the nervous system
61
Biology
Undergraduate 2
07/13/2008

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Cards

Term
Name some ways that microbes can enter the nervous system?
Definition
  • through the skull, backbone fracture
  • medical procedures
  • along peripheral nerves
  • blood or lymph
Term
What are the 2 systems of the nervous system?
Definition
  • central nervous system - spinal cord, brain
  • peripheral nervous system - the rest of the body and the outside environment
Term

Where does bacteria often grow in the brain?

Definition
It can grow in the cerebrospinal fluid in the subarachnoid space.
Term
What prevents passage of some materials such as antimicrobial drugs into the CNS?
Definition
The blood brain barrier (capillaries)
Term
What is meningitis?
Definition
inflammation of the meninges
Term

What is encephalitis?

Definition

inflammation of the brain

 

Term
What are the layers of the skull bone to the brain?
Definition
  • skull bone
  • dura mater
  • arachnoid mater
  • subarachnoid space*
  • pia mater
  • cerebrum
Term
What are the effects of bacterial meningitis?
Definition
  • fever, headache, stiff neck
  • nausea and vomiting
  • may progress to convulsion and coma
Term
What antimicrobial drug can treat bacterial meningitis?
Definition
cephalosporin
Term
What type of tests do health workers use to determine bacterial meningitis?
Definition
  • gram stain
  • latex agglutination of CSF
Term
  • Occurs mostly in children ( 6 mths - 4 yrs)
  • capsule antigen type b
  • it is prevented by the Hib vaccine
Definition
haemophilius influenza meningitis
Term
Meningococcal meningitis
Definition
Neisseria Meningitis
Term
10% of people are healthy nasopharyngeal carriers of this microorganism...
Definition
neisseria meningitis
Term
What meningitis disease often happens in college campuses?
Definition
neisseria meningitis
Term
Streptococcus pneumoniae meningitis
Definition
pneumonoccal meningitis
Term
70% of people are normal nasopharyngeal carriers of this microorganism...
Definition
pneumonococcal meningitis
Term
What are the mortality rates of pneumonoccal meningitis for children and elderly adults?
Definition
  • children - 30% mortality
  • elderly - 80% mortality
Term
Listeriosis
Definition
Listeria monocytogenes
Term
This bacteria is usually food born but can be transmitted to fetus. It can reproduce in phagocytes
Definition
listeria monocytogenes
Term
Tetnus
Definition
Clostridium Tetani
Term
Where does tetanus grow on the body?
Definition
it grows in deep wounds
Term

Where does tetanospasmin come from and what does it do?

Definition
It is released from dead cells and it blocks relaxation pathway to muscles
Term

How can tetanus be treated?

Definition
with tetanus immune globulin
Term
Botulism
Definition
Clostridium botulinum
Term

How does a person get botulism?

Definition
It comes from ingesting botulinal toxins
Term
What does botulism do?
Definition
Botulinal toxins block release of neurotransmitter causing flaccid paralysis
Term
What bacteria grows in can food that contains a small pinpoint hole in it ?
Definition
Botulism
Term

Botulism:

60-70% mortality

Found in CA, WA, CO, OR, NM

 

Definition
Type A botulism
Term

Botulism:

20% fatality

Europe and eastern united states

Definition
Type B
Term

Botulism:

Found in marine and lake sediments

pacific northwest, alaska, great lakes

Definition
Type E
Term
Leprosy
Definition
Mycobacterium leprae
Term
Where does mycobacterium leprae grow in the body?
Definition
in peripheral nerves and skin cells
Term
How is leprosy contracted?
Definition
Prolong contact with an infected person
Term
What are the 2 types of leprosy?
Definition
  • Tuberculoid (neural) form
  • Lepromatous (progressive) form
Term
Type of leprosy that results in loss of sensation in skin areas; positive lepromin test
Definition
Tuberculoid (neural) form
Term
Type of leprosy that results in disfiguring nodules over body; negative lepromin test
Definition
lepromatous (progressive) form
Term
Poliomyelitis
Definition
Polio virus
Term
How is polio transmitted?
Definition
through ingestion
Term
What are the initial symptoms of polio?
Definition
sore throat and nausea
Term
Rabies
Definition

Rhabdovirus

Term
How is rabies transmitted?
Definition
through animal bite
Term
how does Rabies infect the body?
Definition
Bacteria multiplies in the skeletal muscles then travels to the brain causing encephalitis
Term
What are some initial symptoms of rabies?
Definition

muscle spasms

hydrophobia

Term
Animals are restless then highly excitable
Definition
furious rabies
Term
animals seem unaware of its surrounding
Definition
paralytic rabies
Term
Infection of the human diploid cells vaccine
Definition
preexposure prophylaxis
Term
Vaccine plus immune globulin
Definition
postexposure treatment
Term

Arboviral encephalitis

Definition
Arbo virus
Term
How does a person contract arboviral encephalitis?
Definition
being bitten by arthropods therefore prevention is controlling mosquitos
Term
West nile
Definition
arboviral encephalitis
Term
Cryptococcus neoformans meningitis
Definition
cryptococcosis
Term

Soil fungus associated with pigeon and chicken droppings

Definition
cryptococcosis
Term
How is cryptococcosis transmitted?
Definition
through respiratory route then it spreads to the CNS
Term
What is the mortality rate of cryptococcosis?
Definition
30% mortality
Term
What are treatments of cryptococcosis
Definition

Amphotericin B and flucytocine

Term
African Trypansomiasis
Definition
Trypanosoma brucei gambiense
Term
Type of infection that is chronice to 2 - 4 years
Definition
trypanosoma brucei gambiense
Term
How is African Trypanosomiasis transmitted?
Definition
It is transmitted from the tsetse fly to humans
Term

Protozoan infects nasal mucosa from swimming water

Definition

Naegleria fowleri

Term
Spongiform encephalitis
Definition
caused by prions
Term
What are 2 spongiform encephalitis diseases?
Definition

creutzfieldt jakob disease

kuru disease

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