Term
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Definition
| chemotherapeutic drugs that interfere w/ microbial growth within a host |
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Term
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Definition
is a trait of a desirable drug
-its a drug that targets pathogens w/o harming the host |
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Term
Narrow Spectrum
Example drug |
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Definition
target specific groups of microbes
-Acyclovir for viruses |
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Term
Broad Spectrum
Example drug
Effects what type of bacteria |
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Definition
affects many types of microbes
Amoxicillin and Tetracycline
Gram + and - |
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Term
5 Modes/Mechanisms of Action of Antimicrobial Drugs
(CMPPN) |
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Definition
1. Inhibit cell wall synthesis
2. Inhibit protein synthesis
3. Damages plasma membrane
4. Inhibits synthesis of essential metabolites
5. Inhibits Nucleic Acid Replication and Translation |
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Term
4 ways antimicrobial drugs inhibit proteins synthesis
(IPITAR) |
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Definition
Inhibits peptide bonds formation
Interferes with tRNA attachment
Alters ribosome shape |
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Term
| Drugs that damage plasma membrane? |
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Definition
Polymyxin B
Amphotericin B |
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Term
| Drugs that act as competitive inhibitors (compete for the active site on enzymes) |
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Definition
Sulfa drugs
Synthesis of essential metabolites |
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Term
| Drugs that inhibit Nucleic acid replication and transcription |
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Definition
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Term
Mechanisms Of Drug Resistance
GBEET |
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Definition
1.Blocking entry
2.Inactivating drug by enzymes
3.Alteration of target molecules (change in the drugs target site)
4. Efflux of antibiotic
5. Drug resistance gene spread |
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Term
| The Future of Chemotherapeutic Agents |
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Definition
1.Modify existing drugs
2.Antimicrobial Peptides
3. Antisense Agents |
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Term
Modify existing drugs
(SET) |
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Definition
1. extend their spectrum
2. identify new targets
3. prevent their destruction by enzymes |
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Term
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Definition
| Produced by plants, animals and insects; form disruptive channels in the membrane |
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Term
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Definition
| short synthetic strands of DNA that bind to the pathogen's DNA or RNA responsible for pathogenic effects |
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