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Chapter 19
Cell division
22
Biology
Undergraduate 2
07/26/2011

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Term
cohesin
Definition
direct target of Cdk:cyclin M; around sister chromatids
Term
MARK
Definition
phosphorylated by Cdk:cyclin M; phosphorylates MAPs, causing mitotic catastrophe
Term
mitotic catastrophe
Definition
MT break down into unassociate tubulin
Term
prophase events
Definition
condensing of loops; MT indirectly destabilized; mitotic spindle forms; kinetichore proteins activated indirectly
Term
IPMT
Definition
interpolar microtubules between centrosomes
Term
prometaphase events
Definition
nuclear envelope collapses; kMT attach to kinetichores
Term
lamins
Definition
direct target of Cdk:cyclin M;
Term
metaphase events
Definition
chromosomes aligned along metaphase plate
Term
anaphase events
Definition
cohesins indirectly destroyed; IPMT elongate and kMT shorten; Cyclin M destroyed
Term
APC
Definition
anaphase promoting complex; is a ubiquitin conugating enzyme that adds ubiquitin chains to securrin
Term
securrin
Definition
inhibits separase
Term
separase
Definition
when active, breaks down cohesins
Term
Anaphase A
Definition
shortening of kMT
Term
Anaphase B
Definition
two poles are pushed apart; overlapping region becomes shorter
Term
ex of negative feedback loop
Definition
APC is activated by Cdk:cyclin M then also destroys Ckd:cyclin M
Term
telophase events
Definition
chromosomes at poles; dephosphorylation of lamins; inactivation of condensins
Term
cytokinesis
Definition
contractile ring of actin/myosin II forms in late anaphase; interphase MT cytoskeleton re-forms
Term
interphase MT cytoskeleton
Definition
MAPs are dephosphorylated
Term
meiosis 1
Definition
homologous chromosomes pared at plate and separated as bivalent
Term
Meiosis II
Definition
chromatids separate
Term
Meiosis
Definition
producing 4 haploid cells from 1 diploid cell
Term
bivalents held together
Definition
synaptonemal complex and chiasma
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