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Chapter 18
Cell cycle regulation
17
Biology
Undergraduate 2
07/26/2011

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Term
lamin proteins
Definition
direct target of Cdk:cyclin M
Term
MAPs
Definition
indirect target of Cdk:cyclin M
Term
inhibitor proteins on replication origins
Definition
direct target of Cdk:cyclin M
Term
GRPs
Definition
directy target of Cdk:cyclin G1
Term
GRP-SBF
Definition
activated by Cdk:cyclin G1; positive feeback loop for more Cdk:cyclin G1
Term
G2 checkpoint
Definition
DNA replication done? Damages reparired?
Term
Mitosis checkpoint
Definition
all chromosomes attached to spindle?
Term
G1 checkpoint
Definition
environment ok? DNA damage?
Term
p53
Definition
activated when DNA is damaged; activates transcription of p21
Term
p21
Definition
Cdi that stops the cycle until all damage of DNA is repaired
Term
Wee1
Definition
inhibitor kinase
Term
CaK
Definition
activating kinase
Term
Cdc25
Definition
phosphatase that can take off an inhibitoy phosphate
Term
PDGF receptor
Definition
activates MAPK pathway
Term
PDGF
Definition
binds to PDGF receptor; triggers proliferation of skin cells and lymphocytes
Term
E2F
Definition
inactive when bound to Rb; active when unbound and ativates transcription of S phase genes
Term
Rb
Definition
phosphorylated by MAPK pathway from PDGF
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