Term
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Definition
| Translocation between chromo 8 and 14 |
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Term
| Translocation between chromo 8 and 14 |
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Definition
Causes the c-myc gene from chromo 8 to 14
The gene is now under the regulation of the immunoglobulin heavy chain promoter |
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Term
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Definition
| Translocation of the long arm of the 9th chromosome to the long arm of the 22nd chromosome |
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Term
| Chromosome deformity of Chronic myelogenous leukemia (CML) |
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Definition
| 9q to 22q; causes a fusion protein (Bcr-Abl) |
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Term
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Definition
| Bcr-Abl (Abl stimulates the Ras pathway; increasing cell proliferation) |
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Term
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Definition
Breast cancer development
Ovarian cancer |
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Term
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Definition
Breast cancer development
Pancreatic cancer
Breast cancer in Men |
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Term
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Definition
| Mutations in mismatch repair enzymes |
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Term
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Definition
| Drug used to inhibit mutated HER2 protein (plays a part in Breast cancer) |
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Term
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Definition
| Breast cancer is caused by this receptor mutation |
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Term
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Definition
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Term
| Li-Fraumeni Syndrome mutation |
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Definition
Multiple types of tumors
Secondary mutation of p53 |
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Term
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Definition
Disease of numerous benign, painful, tumors of the nervous system
Mutation of NF-1 |
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Term
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Definition
Anti-apoptotic
Activating mutations lead to cancer |
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Term
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Definition
Pro-apoptotic channel-formers
Deactivating mutations lead to cancer |
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Term
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Definition
Pro-apoptotic BH3-only domains
Deactivating mutations lead to cancer
BH3's bind to either anti or pro apoptotic, activating the pro and inhibiting the anti. |
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Term
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Definition
Mutated in Follicular lymphoma and CML
This gene/mutation is also multi drug resistant |
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Term
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Definition
| Drug designed to bind and inhibit the fusion protein Bcr-Abl fusion protein (philadelphia chromosome) |
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Term
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Definition
Overexpression
Squamous cell carcinoma of the lung |
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Term
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Definition
Amplification
Breast
Ovarian
Lung
Stomach |
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Term
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Definition
Tyrosine kinase
Overexpression
Cytoplasm
Breast cancer |
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Term
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Definition
Transcription factors
Breast cancer |
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Term
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Definition
Translocation: Burkitt Lymphoma
Amplification: Neuroblastoma and Small-cell carcinoma |
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