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Chapter 18
DNA Replication
11
Biology
Undergraduate 1
12/03/2012

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Term
origin of replication
Definition
site where DNA replication begins
Term
helicases
Definition
enzymes that untwist the double helix of DNA at replication forks, separating the two strands and making them available as template strands
Term
single strand banding proteins
Definition
proteins that bind to the unpaired DNA strands during DNA replication, stabilizing and holding them apart while they serve as templates for the synthesis of complementary strands of DNA
Term
topoisomerase
Definition
during DNA replication, topisomerase helps to relieve strain in the double helix ahead of the replication fork
Term
RNA primer
Definition
several complementary strands of RNA added to the lagging strand of DNA by RNA polymerase.
Term
primase
Definition
an enzyme that joins DNA neucleotides to make a primer during DNA replication, using the parental DNA strand as a template
Term
DNA polymerase I, III
Definition
enzymes that catalyze the elongation of new DNA by the addition of neucleotides to the three prime end of an existing chain
Term
antiparallel replication
Definition
DNA can only replicate from the 5 prime to the 3 prime end
Term
Okazaki fragment
Definition
a short segment of DNA synthesized away from the replication fork on a template strand during DNA replication. Many such segments are joined together to make up the lagging strand of newly synthesized DNA.
Term
DNA ligase
Definition
A linking enzyme essential for DNA replication; catalyzes the covalent bonding of the three prime end of one DNA fragment ( such as an Okazaki fragment) to the five prime end of another DNA fragment, such as a growing DNA chain
Term
telomeres
Definition
The tandemly repetitive DNA at the end of a eukaryotic chromosome's DNA molecule; protect organism's genes from being eroded during successive rounds of replication
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