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Chapter 18
Adrenergic blocking drugs
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Professional
02/09/2009

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Term
drugs with a specific receptor affinity that prduce a "mimic" response
Definition
Agonist
Term
drugs that bind to adrenergic receptors and inhibit or block the action of NT
Definition
antagonists
Term
B-blocking drugs that are selective for B1 receptors. also called b1-blocking drugs
Definition
cardioselective b-blockers
Term
Irregular heart rhythms/arrhythmias
Definition
dysrhythmias
Term
production of glucose from glycogen in the liver which is reduced by B blockers
Definition
Glycogenolysis
Term
b blocking drugs that block both b1 and b2 adrenergic receptors
Definition
Nonselective b blockers
Term
abnormally low bp that occurs when a person assumes a standing position from a sittying or lying position
Definition
orthostatic hypotension
Term
Job of adrenergic agonist drugs
Definition
to stimulate the sns
Term
binds to a receptor and causes a response
Definition
agonist
Term
antagonist are also called
Definition
sympatholytics because they lyse or inhibit.
Term
a1 adrenegic receptors are locating on the
Definition
muscle or tissue, or organ that the nerve is stimulatoin
Term
a2 adrenergic receptors are located on the actual nerves that stimulate the presynaptic effector cells.
Definition
Term
wen a blockers inhibit stimulation o fthe sns at the a adrenergic receptor what happens?
Definition
leads to vasodilation, decreased blood pressure, miosis or pupil constriction.
Term
a blockers cause both areterial and venous dilation which reduces periheral vascular resistance and bp therefore they are used to treat.
Definition
Hypertension HBP
Term

___ blockers are given to decrease resistance in blood flow in arteries and veins why?

Definition

to reduce obstructions and give relief

 

ie headaches, they vasoconstric dilated arterioles.

ie: dilatin reduces peripheral vascular resistance and bp.

Term

possible adverse affects of a blockers

Definition

drug allergy

peripheral vascular disease

hepatic and renal disease

coronary artery disease

peptic ulcer

and sepsis

Term
Toxity and removal of a blockers
Definition

stomach emptying by vomit or gastric lavage.

activated charcoal

 

along with suportive measures

bp watch

fluids

vasopressor drugs

 

Term
b blockers are also called
Definition
cardioselective b blockers
Term
_______ competes with and blocks noe and epinephrine at b adrenergic receptors, b receptor sites can no longer be stimulated by NT and sns stimulation is blocked.
Definition
b blockers
Term
b1 blockersblock the b1 adrenergic receptors on the surgace of the heart which reduces?
Definition
myocardial stimulation which in tun reduces the heart rate and slows conduction through the av node, sa node and decreases myocardial O2 demand by decreasing heart contraction force.
Term
non selective b blockersblock b2 adrenergic receptors on the
Definition
smooth muscle of the bronchioles and blood vessels.
Term
b blockers that are selective for b adrenergic receptors
Definition
cardioselective b blockers or b1 blockers
Term
nonselective b blockers block
Definition
both a and b receptors
Term
____ blockers leads to vasodilation, decreased bp, miosis, pupil dilation and decreased ejactulation
Definition

a blockers

Term
2 effects of a blockers
Definition

vasodilation (migrane relief)

Dilation (to decrease bp and arteriole pressure)

Term
__ blockers compete for protein sites with _____ and ___ and are nonselective.
Definition
NOE and EPI
Term
__ blockers blocks b1 and b2 located in the smooth muscle, bronchioles, vessles.
Definition
b
Term
because b blockers compete for b receptor sites with epi and noe. b adrenergic rec. sites can no longer be stimulated so?
Definition
NT and sns stimulation is blocked
Term
cardioselective b blockers block the
Definition
b1 adrenergic rec. on the surface of the heart, which reduces myocardial stimulation, which in turn reduces heart rate.
Term
b blockers are considered
Definition
cardio protective
Term
beta blocker effects on the heart make them good drugs for treatment of
Definition
dysrhythias (irregular heart rhythms)
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