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Chapter 18 - Microbio.
Practical application of immunology
30
Biology
Undergraduate 2
07/02/2008

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Term
What is variolation?
Definition
inoculation of smallpox into skin (18th century)
Term
What is vaccination?
Definition

Inoculation of cowpox into skin

Term
What is herd immunity?
Definition
Results when most of the population is immune to a disease and it protects those who aren't immune.
Term
What DTaP?
Definition
  • Diptheria
  • Tetanus
  • Pertussis
Term

Principle Vaccines used in the US to prevent bacterial diseases in human

Definition
  • DtaP (Diptheria, Pertussis, Tetanus)
  • Meningococcal meningitis
  • haemophilus influenza
  • pneumonoccocal conjugate vaccine
Term
Principle vaccines used in US to prevent VIRAL disease
Definition
  • Live vaccine virus
  • inactiaved virus
  • attenuated virus
  • antigenic fragments
Term
What does MAB stand for?
Definition
Monoclonal antibodies
Term

How are antibodies made?

Definition
It is taken from an infected host from their spleen and then it is put in a suspension of cells. Antibodies will make more of the antibodies.
Term

What are immunotoxins?

Definition
Mabs conjugated with a toxin to target cancer cells (chemotherapy)
Term
What are chimeric mabs?
Definition
Genetically modified mice that produce Ab with a human constant region
Term
What are humanized Mabs
Definition
Mabs that are mostly human, except for mouse antigen-binding.
Term
What are fully human antibodies?
Definition
Mabs produced from a human gene on a mouse
Term

What involve soluble antigens with antibodies?

Definition

precipitation reaction

Term
What is a zone of equivalence?
Definition
Area of visible precipitation
Term
What is an agglutination reactions?
Definition

involve particulate antigens and antibodies

Term
Whee can antigens be during agglutination reaction?
Definition
  • on a cell (direct agglutination)
  • attached to latex spheres (indirect or passive agglutination)
Term
The concentration of antibodies against a particular antigen
Definition
antibody titer
Term
What is viral hemmaglutination?
Definition
involves agglutination of RBCs.
Term

Where can some viruses agglutinate RBCs in?

Definition
vitro = in cell
Term

what inhibits hemagglutination?

Definition
antibodies
Term
What is aIt  neutralization Reaction?
Definition
It eliminates the harmful effect of a virus or exotoxin
Term
What occurs in a complement fixation test?
Definition

1) antigen+complement+serum of antibody against antigen = complement fixation

2)Antigen+complement+serum without antibody = no complement fixation

Term

No hemolysis

Definition

RBC + antibody. The complement is tied up in the antigen-antibody reaction

Term
Hemolysis
Definition

RBC + antibody. Hemolysis. Uncombined complement available.

Term
Fluorescent Antibody Techniques (direct)
Definition
  • Group A of streptococci from patient's throat + fluorescent dye = Fluorescent streptococci
Term
What is a good test for aids?
Definition
ELISA test
Term
a direct serological test
Definition
detect antigens from patient sample
Term

indirect serological test

Definition
detects antibodies from patient's serum
Term
fluorescent antibody technique
Definition
antibodies linked to fluorescent dye
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