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Chapter 17
Adaptive Immunity: Specific Defenses of the Host
48
Microbiology
Undergraduate 1
04/03/2011

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Term
innate immunity
Definition
an individuals genetically predetermined resistance to certain diseases
Term
adaptive imunity
Definition
the ability of the body to specifically react to a microbial infection
Term
B cells
Definition
mature in the bone marrow, produce antibodies
Term
T cells
Definition
mature in the thymus, involved in cell-mediated immunity
Term
plasma
Definition
liquid portion of the blood
Term
serum
Definition
liquid remaining after blood plasma is clotted
Term
antiserum
Definition
the generic term for serium because it contains antibodies
Term
antigen
Definition
a chemical substance that causes the body to produce specific antibodies or sensitied T cells
Term
antibodies
Definition
proteins formed against specific regions on antigens
Term
where the antibody binds
Definition
epitope, or antigenic determinants
Term
hapten
Definition
low-molecular-weigt substance that cannot cause the formation of antibodies unless combined with a carrier molecule
Term
antibody monomer
Definition
contains 4 polypeptide chains and held together by di-sulfide bonds
Term
Fc region
Definition
the stem region of an antibody
Term
V region
Definition
binds to the epitope
Term
C region
Definition
The constant part of all antibodies
Term
IgG antibodies
Definition
most pevalent, fix the complement system,enhance phagocytosis, cross the placenta, monomers and enter tissues
Term
IgM antibodies
Definition
consist of five monomers, agglutination and complement fixation, in blood, lymph and on B cells, first antibody in an infection
Term
IgA antibody
Definition
monomer, dimmers that protect mucosal surfaces from invasion, prevalent in body fluids, in breast milk
Term
IgD antibodies
Definition
on B cells, in blood and lymph, monomers, initiate the immune response
Term
IgE antibodies
Definition
bind to mast cells and basophils (trigger release of histamine), involved in allergic reactions, monomers, lyse parasitic worms,
Term
B cells differentiate into
Definition
plasma and memory cells
Term
affinity
Definition
strength of the bond between Ag and Ab
Term
specificity
Definition
Ab recognizes a specific epitope
Term
antibody-antigen complex
Definition
when an antibody binds to its specific epitopes on an antigen
Term
neutralization
Definition
antibodies attach to microbes or toxins, inhibiting them from adherence
Term
complement activation
Definition
results in cell lysis, cascade effect
Term
Th1 cells
Definition
activate ells involved in cellular immunity
Term
Th2 cells
Definition
activate B cells so they can make antibodies
Term
T cytotoxic cells
Definition
activated by endogenous antigens and MHC class I on a tarfget cells and transformed into CTL
Term
CTLs
Definition
lyse or induce apoptosis in the target cell
Term
Natural Killer cells
Definition
lyse virus-infected cells, tumor cells and parasites
Term
interleukins
Definition
serve as communicators between leukocytes
Term
chemokines
Definition
cause leukocytes to migrate to an infection
Term
alpha and beta interferons
Definition
protect neighboring cells from virus infection by going into the neighboring cell, causing them to make antiviral proteins that block replication of the virus in that cell.
Term
tumor necrosis factor (TNF)
Definition
promotes the inflammatory reaction
Term
antibody titer
Definition
the relative amount of antibody in serum
Term
primary response
Definition
response of the body to the first contact with an antigen, IgM then IgG
Term
Anamnestic response
Definition
the secondary response to an infection, with more and quicker release of antibodies
Term
M cells
Definition
brings in the pathogen in contact with the T and B cels
Term
Naturally aquired active immunity
Definition
immunity resulting from infection
Term
Naturally acquired passive immunity
Definition
antibodies transferred from a mother to a fetus or to a newborn in breast milk
Term
artificially acquired active immunity
Definition
immunity resulting from vaccination
Term
artificially aquired passive immunity
Definition
refers to the humoral antibodies acquired by injection
Term
MHC class I
Definition
on the plasma membranes of all nucleated cells
Term
MHC class II
Definition
on the plasma membrane on antigen presenting cells.
Term
first step of APC
Definition
ingests a microorganism, antigen is processed and comined with MHC class II and are displayed on the surface of the APC
Term
third step of APC
Definition
cytokines from APC cause Th cell to proliferate
Term
second step of APC
Definition
receptor on the surface of the Th cell binds to MHC-antigen complex;
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