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Chapter 17 - microbiology
Adaptive immunity: specific defenses of the host
53
Biology
Undergraduate 3
07/01/2008

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Term
What is innate immunity?
Definition
Defenses against any pathogen
Term
What is adaptive immunity?
Definition
Specific antibody and lymphocyte response to an antigen
Term
What would happen if a person was injected with a weaker pathogen of chicken pox?
Definition
The person would be immune to chicken pox because the weaker pathogen and chicken pox had similar Dna's allowing her to not get sick from it.
Term
Who won the nobel prize for development of an antitoxin
Definition

Von behring

Term
Who's work led to the identification of antibodies in serum?
Definition
Ehrlich's work
Term
A substance that causes the body to produce specific antibodies or sensitized T cells
Definition
Antigen (Ag)
Term
Proteins made in response to an Ag
Definition
Antibody
Term
Serum proteins that bind to Antibodies (Abs) in an Ag-Ab reaction; cause cell lysis
Definition
complement
Term
When does adaptive immunity develop?
Definition
During an individual's lifetime.
Term
Type of immunity which involves antibodies produced by B cells
Definition
Humoral immunity
Term
How do B cells recognize antigens?
Definition
By antibodies on their surfaces. B cells have to look for the antigens like a key and a lock
Term
What type of cell is involved in Cell-immediated immunity?
Definition
T-cell
Term
How do T cells recognize antigens?
Definition
By TCRs on their surfaces
Term
What is serology?
Definition
The study of reactions between antibodies and antigens
Term

What is antiserum?

Definition
The generic term for serum because it contains Ab
Term

What are Globulins?

Definition
Serum proteins
Term

What are immunoglobulins?

Definition
antibodies
Term

What are gamma globulin?

Definition
Serum fraction containing Ab
Term
What is antigenic Determinant?
Definition

They react and recognize

Term
These react with antibodies. alone, they cannot produce an immune response
Definition
Haptens
Term

What structures are in an antibody?

Definition
  • Fc stem region
  • hinge region
  • heavy and light chain
  • antigen binding sites
Term
  • Monomer
  • 80% of serum antibodies
  • fix complement
  • in blood, lymph, intestine
  • crosses placenta
  • enhance phagocytosis
  • half life= 23 days
Definition
IgG antibody
Term
  • Pentamer
  • 5-10% of serum antibodies
  • fix complement
  • in blood, lymph., and B cells
  • agglutinates microbe
  • half life = 5 days
Definition
IgM
Term
  • Dimer
  • 10-15% of serum antibodies
  • in secretions
  • mucosal protection
  • half life= 6 days
Definition
IgA
Term
  • Monomer
  • .2% of serum antibodies
  • in blood, lymph, and b cells
  • on be cells, initiate immune response
  • half life=3 days
Definition
IgD
Term
  • Monomer
  • 0.002% of serum ntibodies
  • on mast cells, basophils, and in blood
  • allergic reaction, lysis of parsitic worms
  • half life=2 days
Definition
IgE
Term
Which antibody is responsible for enhancing phagocytosis?
Definition

igG

Term
Which antibody is first to arrive on the scene during an infection?
Definition
IgM
Term

Which antibody is responsible for mucosal protection?

Definition
IgA
Term
Which antibody is responsible for the immune response on B cells?
Definition
IgD
Term
Which antibody is responsible for allergic reactions?
Definition

igE

Term
What are steps in activating B cells?
Definition
  1. B cells take in extracellular antigen
  2. B cells put it on display on its surface
  3. T cells lock with the extracellular antigens
  4. It makes a plasma membrane
Term
What is clonal selection?
Definition

The process of destroying B and t cells that react to self antigens.

Term
What recognize antigens?
Definition
T cells
Term
These T cells secrete cytokines
Definition
Activated Th cell
Term

What cell leads to antibody production?

Definition
B cells
Term
During embryonic development, regions of V genes combine with C genes to produce > 1015 different antibodies.
Definition
Diversity of Antibodies
Term
What binds with antigen?
Definition
antibodies
Term

What is affinity?

Definition
strength of bond between Ag and Ab
Term

What is specificity?

Definition
When Ab recognizes a specific epitope
Term
Pathogens entering the gastrointestinal or respiratory tract pass through _____
Definition
  • m (microfold) cells over
  • peyer's patches which contain
  • antigen-presenting cells
  • t cells
Term
What are TCRS?
Definition
Recognize antigens and MHC II
Term
What do tH1 cells do?
Definition
activate cells related to cell-mediated immunity (TOLL)
Term
What do Th2 cells do?
Definition
Activate B cells to produce eosinophils, IgM, and IgE
Term
What do regulatory T cells (TR) do?
Definition
suppress other T cells
Term
What is antibody titer?
Definition
amount of Antibodies in Serum
Term

Resulting from infection. You got the infection then got healthy.

Definition
Naturally acquired active immunity
Term
Transplacental or via colostrum. From parents or through the placenta or breast milk
Definition
Naturally acquired passive immunity
Term
Injection of Ag (vaccination)
Definition
Artificially acquired active immunity
Term
Injection of Ab. Being given antibodies.
Definition
Artificially acquired passive immunity
Term

True or false?

Antibody is a protein

Definition
True
Term
What does TCR stand for?
Definition
T cell receptor
Term
What is agglutination?
Definition
The process of suspended bacterias are clump together ; similar to precipitation
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