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Chapter 16
Vocabulary & Key Concept
28
Biology
Undergraduate 1
01/09/2014

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Term
gene expression
Definition
the process of converting archived information into molecules that actually do things in the cell
Term
knock-out/null/loss-of-function alleles
Definition
alleles that do not function at all
Term
genetic screen
Definition
any technique for picking certain types of mutants out of many randomly generated mutants
Term
messenger RNA/mRNA
Definition
carry information out of the nucleus from DNA to the site of protein synthesis
Term
RNA polymerase
Definition
polymerizes ribonucleotides into strands of RNA
Term
central dogma
Definition
DNA -> RNA -> proteins
Term
transcription
Definition
the process of copying hereditary information in DNA to RNA
Term
translation
Definition
the process of using the information in nucleic acids to synthesize proteins
Term
reverse transcriptase
Definition
synthesizes a DNA version of the RNA genes; information flows from RNA to DNA
Term
genetic code
Definition
the rules that specify the relationship between a sequence of nucleotides in DNA or RNA & the sequence of amino acids in a protein
Term
triplet code
Definition
a three-base code
Term
codon
Definition
a group of three bases that specifies a particular amino acid
Term
reading frame
Definition
the sequence of codons
Term
start codon/AUG
Definition
signals that protein synthesis should begin at that point on the mRNA molecule
Term
stop codons/UAA, UAG, UGA
Definition
termination codons
Term
5 important properties of the genetic code
Definition
1. redundant
2. unambiguous
3. non-overlapping
4. nearly universal
5. conservative
Term
mutation
Definition
any permanent change in an organism's DNA
Term
point mutation
Definition
a single-base change
Term
missense mutations
Definition
point mutations that cause a change in the amino acid specified by the codon
Term
silent mutation
Definition
a point mutation that does not change the amino acid sequence of the gene product
Term
frameshift mutations
Definition
a single addition or deletion mutation
Term
nonsense mutation
Definition
a codon that specifies an amino acid is changed by mutation to one that specifies a stop codon
Term
3 categories of mutations
Definition
1. beneficial
2. neutral
3. deleterious
Term
inversion
Definition
segments of chromosomes are flipped & rejoined
Term
translocation
Definition
segments of chromosomes become attached to a different chromosome
Term
deletion
Definition
when a segment of a chromosome is lost
Term
duplication
Definition
when additional copies of a segment are present
Term
karyotype
Definition
the complete set of chromosomes in a cell
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