Term
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Definition
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Term
| Dihydrolipoyl transacetylase |
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Definition
| E2 of PDH complex. Transfers acetyl to CoA. |
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Term
| Dihydrolipoyl Dehydrogenase |
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Definition
| E3 of PDH complex. Regenerates FAD by removing H2 to NAD+ and to free solution |
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Term
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Definition
TPP (from thymine)
NAD+ (from Niacine, accepts electrons)
FAD+ (from riboflavin, accepts electron)
Lipoate (body makes, accepts electrons and acyls)
CoA (from pantathenic acid, is transferred) |
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Term
| Yield from complete oxidation of pyruvate and Acetyl-CoA |
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Definition
Pyruvate: 12.5 (1 extra NADH from Acetyl-CoA)
Acetyl-CoA: 10 (1 ATP, 3 NADH, 1 FADH) |
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Term
| The 4 intermediates of the CAC that can be used for biosynthetic intermediates |
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Definition
| Citrate, alpha-Ketoglutarate, Succinyl-CoA, Oxaloacetate |
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Term
| Intermediates of the Citric Acid Cycle |
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Definition
1. Oxaloacetate
2. Citrate
3. Isocitrate
4. alpha-Ketoglutarate
5. Succinyl-CoA
6. Succinate
7. Fumarate
8. Malate -> 1. |
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Term
| Intermediate: Oxaloacetate/Acetyl-CoA |
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Definition
Oxalacetate + Acetyl-CoA -> Citrate + CoA
Mediated through Citrate synthase, condensation |
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Term
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Definition
Citrate -> Isocitrate
Isomerization, catalyzed by aconitase |
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Term
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Definition
| Isocitrate + NAD+ -> alpha-ketoglutarate + NADH Oxidative carboxylation, catalyzed by isocitrate dehydrogenase |
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Term
| Intermediate: alpha-ketoglutarate |
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Definition
| alpha-keto glutarate + NAD+ -> Succinyl-CoA + NADH Oxidative decarboxylation catalyzed by alpha-ketoglutarate dehydrogenation complex |
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Term
| Intermediate: Succinyl-CoA |
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Definition
| Succinyl-CoA + ADP -> ATP + Succinate Substrate-level phosphorylation catalyzed by succinyl-CoA syntetase |
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Term
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Definition
| Succinate + FAD -> Fumarate + FADH2 Dehydrogenation catalyzed by succinate dehydrogenase |
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Term
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Definition
Fumarase + H2O -> Malate
Hydration catalyzed by fumarase |
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Term
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Definition
Malate + NAD -> Oxaloacetate + NADH + H+
Dehydrogenation catalyzed by malate dehydrogenase |
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