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Chapter 15 - Immune System
Fox, Chapter 15
25
Physiology
Professional
04/19/2012

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Term
innate vs. adaptive immunity
Definition
innate: nonspecific
adaptive: specific
Term
innate immunity
Definition
1. inherited
2. first line of defense
Term
complement system
Definition
1. integrates innate and adaptive responses
2. proteins in plasma become activated when antibodies bind to antigens
3. proteins promote phagocytosis, lysis of cells, inflammation
Term
phagocytosis
(3 types of cells)
Definition
1. neutrophils: first to arrive
2. mononuclear: arrive later
3. organ-specific phagocytes: in organs
Term
interferons
Definition
1. antiviral polypeptides produced by infected cells
2. alpha, beta and gamma
Term
adaptive immunity
Definition
1. acquired ability to defend against specific pathogens after exposure to them
2. mediated by antigens and antibodies
Term
antigens
Definition
1. cell surface molecules that stimulate the production of specific antibodies
Term
haptens
Definition
1. smaller, nontigenic molecules
2. become antigens when bound to other proteins
Term
lymphocytes
Definition
1. derived from stem cells in bone marrow
2. seed the thymus, spleen and lymph nodes
Term
T lymphocytes
Definition
1. attack host cells that have become infected
2. do NOT produce antibodies
3. must be in close proximity to the victim cell in order to destroy it
"cell-mediated immunity"
Term
B lymphocytes
Definition
1. directly from bone marrow
2. combat Bacterial and some viral infections
3. secrete antibodies
"antibody-mediated immunity"
Term
5 classes of antibodies
Definition
IgG
IgA
IgM
IgD
IgE
Term
antibody structure
Definition
1. Y shaped
2. two long, heavy chains joined by two shorter, light chains
Term
cytotoxic T lymphocytes
Definition
1. destroy body cells that harbor foreign antigens
2. cell-mediated struction
Term
helper T lymphocytes
Definition
1. improve ability of B lymphocytes to become plasma cells
2. enhance ability of cytotoxic T cells to kill targets
Term
regulatory T lymphocytes
Definition
1. inhibit response of B and T lymphocytes
2. "supressor T lymphocytes"
3. deficiencies can lead to autoimmune diseases
Term
active immunity
Definition
1. when exposed to foreign antigens, immune cells respond by making many good copies of themselves
2. to protect against future infections
3. used to make vaccines
Term
vaccines
Definition
1. killed virus
2. live virus w/attenuated virulence
3. genetically engineered recombinant virus
Term
passive immunity
Definition
1. passing of antibodies from one individual to another
2. temporary protection
- mother to fetus
- mother to child (breast milk)
- immunization
Term
cancer treatments
Definition
1. therapeutic antibodies
2. interferons
3. interleukin-2
Term
immune system diseases
Definition
1. autoimmune disease
2. allergies
3. immune complex diseases
Term
autoimmune disease
Definition
1. immune cells fail to tolerate "self" antigens and attack self
Term
allergies
Definition
1. hypersensitivity
2. abnormal response to allergens (antigens)
3. immediate and delayed hypersensitivity
Term
immediate hypersensitivity
Definition
1. abnormal B cell response
2. seconds to minutes after exposure
3. foods, bee stings, pollen, etc.
Term
delayed hypersensitivity
Definition
1. abnormal T cell response
2. symptoms 24-72 hours after exposure
3. contact dermititis
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