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Chapter 12
Microbial Genomics
27
Microbiology
Undergraduate 2
03/27/2012

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Term
Bioinformatics
Definition
the use of computational tools to acquire, analyze, store, and access DNA and protein sequences
Term
Chromosomal Island
Definition
a bacterial chromosome region of foreign origin that contains clustered genes for some extra property such as virulence or symbiosis
Term
Codon Bias
Definition
the relative proportions of different codons encoding the same amino acid; it varies in different organisms. same as codon usage
Term
Gene Chip/Microarray
Definition
small solid-state supports to which genes or portions of genes are affixed and arrayed spatially in a known pattern
Term
Gene Family
Definition
genes related in sequence to each other because of common evolutionary origin
Term
Genome
Definition
the total complement of genetic information of a cell or a virus
Term
Genomics
Definition
the discipline that maps, sequences, analyzes, and compares genomes
Term
Homologs
Definition
genes related in sequence to an extent that implies common genetic ancestry; includes both orthologs and paralogs
Term
Horizontal Gene Transfer
Definition
the transfer of genetic information between organisms as opposed to transfer from parent to offspring
Term
Integrase
Definition
the enzyme that inserts cassettes into an integron
Term
Integron
Definition
a genetic element that collects and express genes carried by cassettes
Term
Interactome
Definition
the total set of interactions between proteins - or other macromolecules- in an organism
Term
Metabolome
Definition
the total complement of small molecules and metabolic intermediates of a cell or organism
Term
Metagenome
Definition
the total complement of all the cells present in a particular environment
Term
Metagenomics
Definition
the genomic analysis of pooled DNA or RNA from an environmental sample containing organisms that have not been isolated; same as environmental genomics
Term
Microarray
Definition
small, solid-state supports to which genes or portions of genes are affixed and arrayed spatially in a known pattern (also known as gene chips)
Term
Open Reading Frame(ORF)
Definition
a sequence of DNA or RNA that could be translated to give a polypeptide
Term
Ortholog
Definition
a gene in one organism because of descent from a common ancestor
Term
Paralog
Definition
a gene whose similarity to one or more other genes in the same organism is the result of gene duplication
Term
Pathogenicity Island
Definition
a bacterial chromosome region of foreign origin that contains clustered genes for virulence
Term
Primer
Definition
an oligonucleotide to which DNA polymerase attaches the first deoxyribonucleotide during DNA synthesis
Term
Proteome
Definition
the total set of proteins encoded by a genome or the total protein complement of an organism
Term
Proteomics
Definition
the genome-wide study of the structure, function, and regulation of the proteins of an organism
Term
RNA editing
Definition
changing the coding sequence of an RNA molecule by altering, adding, or removing bases
Term
Sequencing
Definition
deducing the order of nucleotides in an DNA or RNA molecule by a series of chemical reactions
Term
Shotgun Sequencing
Definition
sequencing of DNA from previously cloned small fragments of a genome in random fashion, followed by computational methods to reconstruct the entire genome sequence
Term
Transcriptome
Definition
the complement of all RNA produced in an organism under a specific set of conditions
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