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Chapter 12 Micro
All those stupid-ass drugs from chapter 12
61
Microbiology
Undergraduate 2
03/29/2010

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Term
Interferon
Definition
Antiviral or anticancer.
Produced by fibroblasts and leukocytes in response to immune stimuli
Term
Saquinavir
Definition
Anti-Viral
Works by inhibition of Viral Assembly/Release
Term
Amantidine
Definition
Antiviral or anticancer
Produced by fibroblasts and leukocytes in response to immune stimuli
Term
Acyclovir
Definition
Antiviral
Works by inhibition of nucleic acid synthesis
Term
Zidovudine (AZT)
Definition
Antiviral
Works by nucleic acid synthesis (Nucleotide analog reverse transcriptase inhibitor)
Term
Nevirapine
Definition
Antiviral
Works by inhibition of nucleic acid synthesis(Non-nucleoside reverse transcriptase inhibitors)
Term
Fuzeon
Definition
Antiviral.
Works by inhibition of virus entry and inhibits receptor binding, fusion, and uncoating.
Term
Amantidine
Definition
Antiviral.
Works by inhibition of virus entry and inhibits receptor binding, fusion, and uncoating.
Term
Tamiflu
Definition
Antiviral.
Works by inhibition of virus entry and inhibits receptor binding, fusion, and uncoating.
Term
Relenza
Definition
Antiviral.
Works by inhibition of virus entry and inhibits receptor binding, fusion, and uncoating.
Term
Metronidazole
Definition
Antiparasite.
Can treat Giardia lamblia, Entamoeba histolytica & Trichomonas vaginalis.
Term
Chloroquine
Definition
A synthetic quinolone.
Antiparasitic
Treats Protozoan Helminthes.
Term
Primaquine
Definition
A synthetic quinolone.
Antiparasitic
Treats Protozoan Helminthes.
Term
Mefloquine
Definition
A synthetic quinolone.
Antiparasitic
Treats Protozoan Helminthes.
Term
Clotrimazole
Definition
A synthetic azole.
A broad spectrum antifungal.
Inhibits ergosterol synthesis which weakens the fungal cell membranes
Term
Fluconazole
Definition
A synthetic azole.
A broad spectrum antifungal.
Inhibits ergosterol synthesis which weakens the fungal cell membranes
Term
Miconazole
Definition
A synthetic azole.
A broad spectrum antifungal.
Inhibits ergosterol synthesis which weakens the fungal cell membranes
Term
Ketoconazole
Definition
A synthetic azole.
A broad spectrum antifungal.
Inhibits ergosterol synthesis which weakens the fungal cell membranes
Term
Amphotericin B
Definition
Macrolide polyene.
Bacteriocidal antifungal.
Causes loss of selective permeability and binds to sterol esterol.
Used to treat candidiasis/yeast infections
Term
Nystatin
Definition
Macrolide polyene.
Bacteriocidal.
Antifungal.
Causes loss of selective permeability and binds to sterol esterol.
Used to treat candidiasis/yeast infections
Term
Sulfonamides
Definition
Antibacterial.
Folic acid (folate pathway) inhibitor. Both cidal and static.
Term
Trimethoprim (TMP)
Definition
Antibacterial.
Folic acid (folate pathway) inhibitor. Both cidal and static.
Term
Trimethoprim-sulfamethoxazole (TMP-SMX)
Definition
Antibacterial.
Folic acid (folate pathway) inhibitor. TMP-SMX works synergistically to block metabolic pathways at different sites. Both cidal and static.
Term
Daptomycin
Definition
Cell membrane inhibitor.
Antibacterial lipopeptide.
Effective against limited gram positive bacteria.
Causes depolarization of cell membranes.
Active against methicillin-susceptible and resistant Staphylococci, Streptococci, Enterococci, Bacillus species.
Term
Polymyxin B
Definition
Cell membrane inhibitor.
Antibacterial lipopeptide.
Effective against limited gram negative bacteria.
Interacts w/ phospholipids & increases membrane permeability
Term
Metronidazole
Definition
Bactericidal.
DNA&RNA inhibiting antibacterial. Effective against bacterial protozoa. Produces cytoxic compounds that disrupt DNA
Term
Gatifloxacin
Definition
Fluoroquinolone.
Antibacterial.
DNA&RNA inhibitor.
Bactericidal and effective against limited gram positive bacteria.
Term
Gemifloxacin
Definition
Fluoroquinolone.
Antibacterial.
DNA&RNA inhibitor.
Bactericidal and effective against limited gram positive bacteria.
Term
Moxifloxacin
Definition
Fluoroquinolone.
Antibacterial.
DNA&RNA inhibitor.
Bactericidal and effective against limited gram positive bacteria.
Term
Trovafloxacin
Definition
Fluoroquinolone.
Antibacterial.
DNA&RNA inhibitor.
Bactericidal and effective against limited gram positive bacteria.
Term
Cinoxacin
Definition
Bactericidal.
DNA&RNA inhibitor.
Quinolone.
Effective against limited gram negative bacteria
Term
Nalidixic acid
Definition
Bactericidal.
DNA&RNA inhibitor.
Quinolone.
Effective against limited gram negative bacteria
Term
Rifampin
Definition
DNA&RNA inhibiting.
Ansamycin.
Effective against limited bacteria. Cannot pass through the envelope of gram negative bacilli.
Term
Chloramphenicol
Definition
Phenicol.
50s ribosomal inhibitor.
Antibacterial.
Broad spectrum.
Bacteristatic.
Given to seriously ill patients because long term use can result in aplastic anemia.
Term
Linezolid
Definition
Oxazolidone.
50s ribosomal inhibitor.
Antibacterial.
Used for methicillin-resistant staphylococci and vancomycin-resistant enterococci.
Term
Clindamycin
Definition
Broad spectrum.
Lincosamide.
Cidal or static antibiotic.
50s ribosomal inhibitor.
Has better antibacterial activity and improved adsorption after oral administration
Term
Lincomycin
Definition
Broad spectrum.
Lincosamide.
50s rimbosomal inhibitor.
Antibiotic
Term
Telithromycin
Definition
50s ribosomal inhibiting.
Ketolide.
Bactericidal against respiratory pathogens and inter-cellular bacteria. Derivative of Erythromycin.
Good for treating community-acquired respiratory tract infections.
Term
Azithromycin
Definition
50s ribosomal inhibitor.
Broad spectrum antibiotic. Bacteristatic except against streptococci which is bactericidal.
Term
Clarithromycin
Definition
50s ribosomal inhibitor.
Broad spectrum antibiotic. Bacteristatic except against streptococci which is bactericidal.
Term
Dirithromycin
Definition
50s ribosomal inhibitor.
Broad spectrum antibiotic. Bacteristatic except against streptococci which is bactericidal.
Term
Erythromycin
Definition
50s ribosomal inhibitor.
Broad spectrum antibiotic. Bacteristatic except against streptococci which is bactericidal.
Term
Tigecycline
Definition
30s ribosomal protein inhibitor. Antibacterial.
Glycylcycline.
This is the only approved glycylcycline.
Term
Doxycycline
Definition
30s ribosomal inhibiting.
Tetracycline.
Broad spectrum.
Antibacterial.
Administered orally.
Used to treat anthrax.
Term
Minocycline
Definition
30s ribosomal inhibiting.
Tetracycline.
Broad spectrum.
Antibacterial.
Administered orally.
Term
Tetracycline
Definition
30s ribosomal inhibiting.
Broad spectrum.
Antibacterial.
Administered orally.
Term
Aminocyclitols
Definition
Affective against limited bacteria. 3
0s ribosomal inhibitor.
Bacteristatic.
Used to treat Neisseria gonorrhoeae.
Term
Vancomycin
Definition
Non-beta lactam.
Cell wall inhibiting.
Antibacterial.
Effective against aerobic and anaerobic G+ bacteria.
Inactive against G- & mycobactria.
Used to treat MRSA.
Term
Fosfomycin
Definition
Non beta lactam.
Cell wall inhibiting.
Broad spectrum.
Used in the treatment of UTI's (urinary tract infections).
Term
Bacitracin
Definition
Non beta lactam.
Antibacterial.
Cell wall inhibiting.
Effective against G+ bacteria. Administered topically.
Term
Carbapenems
Definition
Beta lactam.
Cell wall inhibiting.
Broad spectrum.
Cause cell elongation & lysis.
Stable against beta-lactamases
Term
Aztreonam
Definition
Monobactam.
Cell wall inhibitor.
Narrow spectrum antibiotic used for treatment in penicillin allergic patients.
Not effective against beta-lactamases
Term
Cephalosporin
Definition
Broad spectrum.
Cell wall inhibitor.
Not effective against most penicillinases.
Similar to the action of penicillin but causes less allergies.
Term
Penicillin V and G
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Most important natural forms.
Term
Ampicillin
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Penicillinase-resistant penicillin.
Term
Carbenicillin
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Penicillinase-resistant penicillin.
Term
Amoxicillin
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Penicillinase-resistant penicillin.
Term
Mezlocillin
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Can be substituted for combinations of antibiotics.
Very broad spectrum.
Term
Azlocillin
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Can be substituted for combinations of antibiotics.
Very broad spectrum.
Term
Augmentin
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Amoxicillin combined with clavulanic acid
Term
Zosyn
Definition
Cell wall inhibiting.
Penicillin.
Bactericidal.
Low toxicity to host.
Zosyn is Tazobactam combined with piperacillin
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