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Chapter 11
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75
Biology
Undergraduate 1
11/15/2010

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Term
Four events that must occur for cell division
Definition
-reproduction signal
-replication of DNA
-segregation
-cytokinesis
Term
Segregation
Definition
distribution of the DNA into the two new cells
Term
Cytokinesis
Definition
Separation of the two new cells
Term
Binary Fission
Definition
how prokaryotes result in two new cells
Term
Description of a prokaryote chromosome
Definition
singular, circular, made of DNA
Term
Ori
Definition
where replication starts
Term
ter
Definition
where replication ends
Term
T or F eukaryotes usually have more than one chromosome
Definition
True
Term
Sister Chromatids
Definition
newly replicated chromosomes are closely associated
Term
Mitosis
Definition
separates the sister chromatids into two new nuclei, and the resulting cells are identical to the parent cell
Term
Cell Cycle
Definition
the period between cell divisions, divided into interphase and mitosis/cytokinesis
Term
Interphase
Definition
the nucleus is visible and normal cell functions occur
Term
G1
Definition
chromosomes are single and unreplicated
Term
Restriction Point (R)
Definition
between G1 and S
a commitment is made for DNA replication and cell division
Term
S phase
Definition
DNA replicates, chromosomes become 2 sister chromatids
Term
G2
Definition
cell prepares for mitosis
Term
Cyclin-dependent kinases (Cdk's)
Definition
catalyzes the phosphorylation from ATP to a protein and changes the shape and function of protein
Term
Cdk is activated by binding to
Definition
cyclin
Term
Growth Factors
Definition
external chemical signals that stimulate cells to divide
Term
Platelet-derived growth factor
Definition
from platelets that initiate blood clotting
Term
interleukins
Definition
produced by WBC that promote cell division in other WBC
Term
Erythropoietin
Definition
produced in the kidneys stimulate division of bone marrow cells and production of RBC
Term
chromatin
Definition
DNA is complexed with proteins densely-packed
Term
Centromere
Definition
hold the sister chromatids together
Term
Histones
Definition
proteins with positive charges that attract negative phosphate groups of DNA
Term
Nucleosomes
Definition
beadlike units
Term
Centrosome
Definition
determines the plane of cell division and doubles during the S phase
Term
centrioles
Definition
hollow tubes formed by microtubules at right angles (2)
Term
T or F plants cells lack centrosomes but have distinct microtubule organizing centers
Definition
True
Term
5 phases of Mitosis
Definition
Prophase, Prometaphase, Metaphase, Anaphase, Telophase
Term
Prophase
Definition
chromatids condense and become visible
Term
Kinetochores
Definition
develop in the centromere regions on each sister chromatid to aid in chromosome movement
Term
Serves as mitotic poles
Definition
centrosomes
Term
Spindle
Definition
microtubules extended from the poles
Term
Polar microtubules
Definition
form spindle framework and run pole to pole
Term
Kinetochore microtubules
Definition
attach to kinetochores on the chromatids
Term
Prometaphase
Definition
nuclear envelope breaks down and sister chromatids attach to the kinetochore microtubules
Term
Metaphase
Definition
chromosomes line up at the midline of the cell
Term
Anaphase
Definition
sister chromatids separate and move to opposite ends becoming daughter chromosome
Term
Cytoplasmic dynein
Definition
a kinetochore protein that hydrolyzes and moves chromosome towards the poles
Term
Telophase
Definition
spindle breaks down, chromosomes uncoil, nuclear envelope and nucleoli appear, 2 daughter nuclei form
Term
Cell Plate
Definition
in plants, the contents of vesicles form it to begin a new cell wall
Term
Asexual reproduction
Definition
based on mitotic division of the nucleus
-the offspring are clones(identical) to parents
Term
sexual production
Definition
offspring are not identical to the parents
-require gametes
Term
Haploid
Definition
they contain only one set of chromosomes (ex gametes)
Term
Fertilization
Definition
two haploid gametes fuse to form a diploid gamete
Term
Somatic Cells
Definition
body cell, contain 2 sets of chromosomes
Term
Homologous pairs
Definition
pair with corresponding genes
Term
diplontic life cycle
Definition
in animals and some plants gametes are the only haploid stage
Term
Meiosis
Definition
nuclear division in cells involved in sexual reproduction
-has 2 nuclear divisions but DNA replicated only once
Term
Cohesion
Definition
holds together two sister chromatids in meiosis I
Term
synapsis
Definition
process of homologous chromosomes pairing in prophase I
Term
tetrad/ bivalent
Definition
the four chromatids of each homologous pair
Term
chiasmata
Definition
homologs are held together here and form between non-sister chromatids
Term
crossing over
Definition
exchange of genetic material that occurs at the chiasmata
Term
recombinant chromatids
Definition
have increased genetic variability and diversity
Term
Independent assortment
Definition
allows for chance combinations of chromosomes in the daughter cell, further contributing to genetic diversity
Term
Nondisjunction
Definition
homologous chromosomes fail to separate during meiosis I, sister chromatids fail to seperate during meiosis II
Term
aneuploidy
Definition
chromosomes lacking or present in excess
Term
trisomic 21
Definition
results in Down syndrome
Term
Translocation
Definition
a piece of chromosome may break off and attach to another chromosome
Term
polyploid
Definition
organism with complete extra sets of chromosomes
Term
necrosis
Definition
cell is damaged or starved for oxygen or nutrients
-cell swells and burst
Term
Apoptosis
Definition
is genetically programed cell death because cell is no longer needed or because cell is old
Term
Blebs
Definition
membranous lobes that break into fragments
Term
Caspases
Definition
hydrolyze proteins of membranes
Term
Cancer cells
Definition
lose control over cell division
can migrate to other parts of the body
Term
tumor
Definition
large mass of cells
Term
benign tumor
Definition
resemble the tissue they grow from and grow slowly and remain localized
Term
malignant tumor
Definition
do not resemble the tissue they grow from and may have irregular structures
Term
metastasis
Definition
cancer cells that invade surrounding tissue and travel through the bloodstream
Term
oncogene
Definition
proteins are positive regulators of cancer
Term
tumor suppressors
Definition
positive regulators in both cancer and normal cells, but are inactive in cancer cells
Term
5-flouracil
Definition
block thymine
Term
taxol
Definition
interferes with the mitotic spindle
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