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Chapter 1
Structure of the Neuron & Organization of Nervous Tissue
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Undergraduate 3
09/08/2015

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Term
The nervous system is built up of nerve cells (called _____) & special kinds of supporting cells (called _____)
Definition
neurons; glial cells
Term
soma
Definition
the cell body of a neuron from which several processes extend; AKA the perikaryon
Term
Multiple short _____ extend the receiving surface of the neuron
Definition
dendrites
Term
A single _____ conducts nerve impulses to other neurons or to muscle cells
Definition
axon
Term
nerve impulse
Definition
an electrical discharge that is how neurons respond to stimuli
Term
conduction
Definition
the transmission of a nerve impulse by a neuron
Term
synapse
Definition
the site of contact between the axon & the next neuron
Term
neurotransmitter
Definition
the chemical signal released from one neuron to the next when the nerve impulse reaches the synapse
Term
axon terminal
Definition
the location from where a neurotransmitter is released to convey a chemical signal from one neuron to the next
Term
2 broad groups of neurons
Definition
1. projection neurons (transmit signals over long distances)
2. interneurons (mediate cooperation among neurons that lie grouped together)
Term
myelin sheath
Definition
rounds the axons of many neurons to increase the speed of impulse propagation
Term
What two colors of nervous tissue are the most common?
Definition
gray matter & white matter
Term
nucleus
Definition
a group of neuronal somata that share connections & functional characteristics in the CNS
Term
ganglion
Definition
a group of neuronal somata that share connections & functional characteristics in the PNS
Term
tract
Definition
a bundle of axons that interconnect nuclei in the CNS
Term
neuronal networks
Definition
groups of neurons that are interconnected & are responsible for performing the tasks of the CNS
Term
divergence
Definition
each neuron influences many other neurons in the CNS
Term
convergence
Definition
each neuron receives synaptic contacts from many others in the CNS
Term
By _____, building materials & signal substances can be brought from the cell soma to the nerve terminals & signal substances are carried from the nerve terminal to the soma
Definition
axonal transport
Term
Do neurons have cell bodies with a nucleus surrounded by cytoplasm containing various organelles?
Definition
yes!
Term
2 main kinds of processes that extend from the cell body
Definition
dendrites & axons (AKA nerve fibers)
Term
axon collaterals
Definition
side branches sent off from the parent axon
Term
spinae/spines
Definition
small spikes that often are on dendrites which are sites of contact with other neurons
Term
Most neurons have several processes & are therefore called _____
Definition
multipolar
Term
Neurons in which one branch conducts impulses from the receptor toward the cell soma & the other conducts impulses toward & into the CNS are called _____
Definition
pseudounipolar
Term
Neurons that have two processes, one conducting toward the cell body & the other away from it are called _____
Definition
bipolar
Term
boutons
Definition
club-shaped enlargements on the terminal branches of an axon
Term
terminal bouton/nerve terminal
Definition
a bouton that sits at the end of an axon branch
Term
en passage boutons
Definition
a bouton that is only a thickening along the course of the axon; axons may have several alone one terminal branch
Term
synaptic vesicles
Definition
small vesicles in the bouton where the neurotransmitter is at least partly located
Term
Can the synaptic cleft be observed under a light microscope?
Definition
no!
Term
presynaptic membrane
Definition
the membrane of the bouton facing the cleft
Term
postsynaptic membrane
Definition
the membrane of the cell that is contacted across the synaptic cleft
Term
How does the postsynaptic density connect to the cytoskeleton?
Definition
with actin filaments & other proteins
Term
cadherins
Definition
proteins in the postsynaptic density that bind to corresponding proteins in the presynaptic membrane to keep the nerve terminal in place
Term
axosomatic
Definition
synapses formed on the cell soma
Term
axodendritic
Definition
synapses on dendrites
Term
axoaxonic
Definition
synapses formed with a bouton & an axon
Term
What color does myelin appear?
Definition
white
Term
nerve/peripheral nerve
Definition
a collection of axons in the PNS
Term
wiring pattern
Definition
how the various neuronal groups are interconnected in the brain
Term
reciprocal connections
Definition
when a nucleus receives connections from the nuclei to which it sends axons
Term
feedback
Definition
back-projections from reciprocal connections; the first nucleus is informed of the outcome of impulses emitted to the second one
Term
bilateral connections
Definition
when many nuclei in the CNS have connections with both sides of the brain
Term
commissural connections
Definition
direct connections between corresponding parts in the two brain halves; demonstrates that the two sides of the CNS cooperate extensively
Term
distributed system
Definition
the parts of the brain that are responsible for a specific function
Term
The organization of the brain in distributed systems is particularly clear with _____
Definition
higher mental functions
Term
An important feature of distributed systems is that _____ can degrade their performance but seldom eliminate it
Definition
partial damage
Term
cytoskeleton
Definition
important for development & maintenance of neuronal shape
Term
Neurofibrils of the cytoskeleton are responsible for the transport of _____ in the neuronal processes
Definition
organelles
Term
anterograde axonal transport
Definition
transport from the cell body toward the nerve terminals
Term
retrograde axonal transport
Definition
transport toward the cell body from the nerve terminals
Term
3 main kinds of fibrillary proteins in the cytoskeleton
Definition
1. actin filaments
2. microtubules
3. intermediary filaments
Term
Is actin present in the axon?
Definition
yes!
Term
When the axon elongates, actin together with microtubules serves to produce movements of the _____ at the tip of the axon
Definition
growth cone
Term
What fibrillary protein is important for neuronal process shape?
Definition
microtubules
Term
What percent of axonal proteins are intermediary filaments?
Definition
10%
Term
2 phases of axonally transported material
Definition
1. rapid (carries mainly organelles & vesicles...membrane-bound structures)
2. slow (carries mainly enzymes & components of the cytoskeleton)
Term
tubulin
Definition
the protein that makes up microtubules
Term
MAPs
Definition
help the formation of the tubes in microtubules from many tubulin molecules
Term
MAP2 & tau
Definition
two kinds of MAPs found only in neurons that stiffen the microtubules
Term
kinesin
Definition
proteins that are responsible for anterograde movement
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