Term
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Definition
Immediate/ Allergic/ Atopy hypersensitivity
IgE, cytokine, and Mast Cell mediated
Vascular and Smooth muscle reaction
(Th2 activation causes production of IgE antibodies) |
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Term
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Definition
Antibody (non-IgE) mediated hypersensitivity that produces antibodies against cell or tissue.
IgM and IgG mediated
ANTIBODIES TO CD20 CAUSES B-CELL INACTIVATION |
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Term
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Definition
Antibodies against soluble antigens, with immune complexes depositing in blood vessels, causing inflammation and tissue damage.
IgM and IgG mediated
ANTIBODIES TO CD20 CAUSES B-CELL INACTIVATION |
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Term
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Definition
T-lymphocyte driven response against self-antigens in tissues.
CD4+ and CD8+ T cells
USUALLY NOT SYSTEMIC
Disorders are usually chronic and progressive
TREAT WITH CYCLOSPORINE, CORTICOSTEROIDS AND CYTOKINE ANTAGONISTS |
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Term
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Definition
| Secrete IL-4 and IL-13 to cause B-cell switching to IgE antibodies. |
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Term
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Definition
| Secrete IL-4 and TNF to promote neutrophil and eosinophil rich inflammation |
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Term
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Definition
Causes:
Vascular dilation
Smooth Muscle Contraction |
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Term
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Definition
| Causes eosinophil activation |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Smooth muscle contraction
Bronchial constriction |
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Term
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Definition
| Inhibits mast cell degranulation |
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Term
| Phosphodiesterase Inhibitors |
|
Definition
| Relax bronchial smooth muscles |
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Term
|
Definition
Smooth Muscle contraction
Increases Cardiac Output
Inhibits Mast Cell degranulation |
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Term
| Autoimmune Hemolytic Anemia |
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Definition
Target:Erythrocyte membrane proteins (Rh blood group and I antigens)
Mech: Opsonization and phagocytosis of erythrocytes
Path: Hemolysis and Anmeia |
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Term
| Autoimmune thrombocytopenic purpura |
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Definition
Target: Platelet membrane proteins (GPIIb/IIIa)
Mech:Opsonization and phagocytosis
Path: Bleeding |
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Term
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Definition
Target: Epidermal cadherin
Mech: Activation of proteases by antibodies
Path: Skin vesicles (bullae) |
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Term
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Definition
Target: Protein in basement membrane of kidney glomeruli and lung alveoli
Mech:Complement and Fc receptor-mediated inflammation
Path: Nephritis and lung hemorrhages |
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Term
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Definition
Target: Streptococcal cell wall antigen
Mech: Inflammation and macrophage activation
Path: Myocarditis and arthritis |
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Term
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Definition
Target: Acetylicholine receptor
Mech: Antibody inhibits acetylcholine binding
Path: Muscle weakness and paralysis |
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Term
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Definition
Target: TSH receptor
Mech: Antibody mediated stimulation
Path: Hyperthyroidism |
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Term
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Definition
Target: Intrinsic factor of gastric parietal cells
Mech: Neutralization of intrinsic factor, decreased absorption of vitamin B12
Path: Abnormal erythropoiesis and anemia |
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Term
| Systemic lupus erythematosus |
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Definition
Type III
AB: DNA, nucleoproteins, others
Path: Nephritis, arthritis, and vasculitis |
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Term
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Definition
Type III
AB: Hepatitis B virus surface antigen
Path: Vasculitis |
|
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Term
| Post-streptococcal glomerulonephritis |
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Definition
Type III
AB: Streptococcal wall antigen
Path: Nephritis |
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Term
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Definition
Type III Clinical and Experimental
AB: Various proteins
Path: Systemic vasculitis, nephritis, and arthritis |
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Term
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Definition
Type III experimental
AB: Various proteins
Path: Cutaneous vasculitis |
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Term
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Definition
Target: Unknown
Genetic: PTPN22
Path:Inflammation of synovium and erosion of cartilage and bone |
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Term
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Definition
Target: Myelin proteins
Genetic: CD25
Path: Demyelination of neurons in CNS with sensory and motor deficits |
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Term
| Inflammatory Bowel Syndrome |
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Definition
Target: Unknown (Microbes?)
Genetic: NOD2 |
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Term
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Definition
Target: Modified Skin proteins
Genetic: None
Path: DTH reaction in skin, rash |
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Term
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Definition
Target: EBNA (viral protein)
Path: CD8+ CTL-mediated hepatocyte death, liver dysfunction, and fibrosis |
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Term
| Super antigen mediated diseases (Toxic Shock Syndrome) |
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Definition
Target: Polyclonal (microbial super antigens activate many T-cells (many self-reactive))
Path: Fever, systemic cytokine release |
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