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| Friedrich Miescher (1860) |
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Definition
| 1st discovered DNA in WBCs from wounded soldiers (called Nuclein) |
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| Frederick Griffith (1928) |
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| British; 1st discovered TRANSFORMATION in heat-killed bacteria |
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| Building block (monomer) of DNA molecule |
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| Holds two strands of DNA together; connects base pairs (weak) |
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| Showed (in vitro) DNA = T.P. ( used DNAases & Proteinases) |
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| Proved phage DNA injected into host (used radioactive S & P isotype) |
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| Order of these makes us UNIQUE |
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| Studied gene function & location by crossing many MUTANT flies |
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| A virus that infects BACTERIA |
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| PURINE nitrogen bases; contain DOUBLE ring |
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| PENTOSE sugar in DNA; missing OXYGEN on #2 Carbon |
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| Two DNA strands join in opposite directions (3' end with 5' end) |
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| Forms repeating backbone of DNA molecule ( same for all) |
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| DISTANCE of one complete turn of DNA |
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| Winding, two strand arrangement of DNA (base pairs = rungs) |
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| Main molecule of HEREDITY (double stranded nucleic acid) |
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| Enzyme connects NUCLEOTIDES during DNA replication |
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| Discovered BASE PAIRING rules (A + G) = (T + C) for all species |
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| Semi-Conservative Replication |
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Definition
| Nature of DNA REPLICATION (i.e. One "old" + one "new") |
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| Developed Chromosomal Theory of Inheritance (genes on chromosomes) |
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| # of nitrogen bases in each human cell (46 chromosomes) |
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| PYRAMIDINE nitrogen bases; contain SINGLE ring |
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| Took X-rays of DNA; data for Watson and Crick |
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| Developed DOUBLE HELIX model of DNA; complementary BP |
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| Distance between successive base pairs |
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| ENZYME that creates NEW DNA strand from OLD template |
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