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Chapter 10 pt2
Alcoholic Liver Disease
19
Other
Professional
03/06/2013

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Term
What are implicated in the pathogenesis of alcoholic liver disease?
Definition
cytokins
Term
What do cytokins activate?
Definition
Kupffer cells, leading to enhanced chemokine release
Term
What do chemokines do?
Definition
Chemokines, in turn, directly and indirectly damage liver hepatocytes
Term
What is the earliest change seen in alcohol liver disease?
Definition
fatty liver
Term
What is the second and more serious form of alcoholic liver disease?
Definition
alcoholic hepatitis
Term
What is the third and most serious form of alcoholic liver disease?
Definition
cirrhosis
Term
Ethanol can develop and travel to the brain in cirrhosis, what can this cause?
Definition
-Dementia and psychosis
-Cerebellar degeneration
-Upper alimentary tract cancer and liver cancer
-Hematopoietic changes
Term
What is , severe alcoholic steatohepatitis characterized by?
Definition
by the sudden development of tender hepatomegaly, jaundice, and fever in a person who has been drinking heavily, flulike
Term
What is a significant feature in advanced kidney disease?
Definition
bleeding tendencies
Term
The clinical presentation of alcoholic hepatitis often is nonspecific and may include...
Definition
nausea, vomiting, anorexia, malaise, weight loss, and fever
Term
Alcoholic cirrhosis may remain BLANK for many years until sufficient destruction of the liver parenchyma has occurred to produce clinical evidence of hepatic failure.
Definition
asymptomatic
Term
What are the steps for the treatment alcoholism?
Definition
1.The first and second steps consist of identification and intervention, respectively
2.A thorough physical examination is performed to evaluate organ systems that could be impaired
3.The third step is to manage the central nervous system depression caused by the rapid removal of the ethanol
Administration of a benzodiazepine, with gradual decrease in serum levels of the drug, alleviates alcohol withdrawal symptoms
Term
What is Disulfiram?
Definition
makes you sick when you consume alcohol, used to treat alcoholism
Term
What are the three areas of concern when treating someone with alcoholic liver disease ?
Definition
-Bleeding tendencies
-Unpredictable metabolism of certain drugs
-Risk of spread of infection
Term
Does a patient wth alcoholic liver disease need a med con?
Definition
yes
Term
Patients with cirrhosis have more what?
Definition
-plaque
-calculus
-gingivitis
**from neglect**
Term
Patients may require more or less medication with alcoholism?
Definition
Liver enzyme induction and central nervous system effects of alcohol in patients with alcoholism can require use of increased amounts of local anesthetic or additional anxiolytic procedures
Term
What is a frequent finding in patients with cirrhosis?
Definition
A bilateral, painless hypertrophy of the parotid glands
Term
Alcohol and tobacco use are both big risk factors for what?
Definition
squamous cell carcinoma
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