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Chapter 10
The Nervous System & Aging
20
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Undergraduate 3
11/22/2015

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Term
4 things that change in your brain as you age
Definition
1. reduction of average brain weight
2. enlargement of the ventricles
3. appearance of degenerative patches
4. neuronal shrinkage
Term
2 things that are reduced in the brain as you age
Definition
1. dendritic trees
2. synaptic numbers
Term
As you age, does blood flow in your brain get increased or reduced?
Definition
reduced
Term
Are both gray and white matter in the brain affected by aging?
Definition
yes!
Term
What is the most constant cognitive sign of aging?
Definition
memory for recent events
Term
Does psychomotor speed increase or decrease as you age?
Definition
decrease
Term
distributed networks
Definition
connect neuronal groups in many parts of the brain
Term
4 reasons for the reduction of gray matter as you age
Definition
1. shrinkage of cell bodies
2. loss of dendritic branches
3. loss of thin axonal branches & nerve terminals
4. loss of water
Term
Where in the cortex is cortical thinning due to aging most marked?
Definition
the prefrontal cortex
Term
Are synapses lost or gained as we age?
Definition
lost
Term
What does loss of dopamine receptors do to an aging brain?
Definition
reduces the signal-to-noise ratio for cortical neurons, making them less specific & more prone to erroneous responses
Term
What causes memory impairments as we age?
Definition
anatomic & physiological changes in the hippocampal region
Term
Do old & young brains have different patterns of cortical activation during cognitive tasks even when performance is equal?
Definition
yes!
Term
What is the difference between old & young brains on memory tests?
Definition
elderly people show less hippocampal activation than young people because of age-related alterations in the hippocampal region
Term
What is the difference between old & young brains for successful motor performance?
Definition
larger parts of the cortex & the cerebellum are recruited in elderly people than in young people
Term
3 causes of dementia
Definition
1. intoxications
2. large tumors
3. infections
Term
What causes the most cases of dementia?
Definition
neurodegenerative diseases leading to progressive neuronal loss
Term
presenile dementia
Definition
dementia developed before the age of 60
Term
Is Alzheimer's disease or frontotemporal dementia more common?
Definition
Alzheimer's
Term
inclusion bodies
Definition
clumps of misfolded proteins in the neuronal cytoplasm that characterize neurodegenerative diseases
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