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Chapter 1 & 5 Notes
Introduction & Homeostasis
58
Physiology
Undergraduate 1
01/18/2011

Additional Physiology Flashcards

 


 

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Term
Fluid not contained within cells
Definition

Extracellular Fluid (EFC)

 

 

Term
Baths blood cells
Definition
Blood Plasma
Term
Bathes most cells in the body, often called tissue fluid
Definition
Interstitial Fluid
Term
Contained within the body cells; often called cytoplasm/cytosol
Definition
Intracelluar Fluid (ICF)
Term
Cerebrospinal fluid, fluid within the eyes, joints, and  body cavities, and fluid secretions of exocrine glands are all classified specifically as
Definition
Transcellular Fluid
Term
What are the two major factors that regulate the movement of water and electrolytes from one fluid compartment to the next?
Definition
Hydrostatic pressure and osmotic pressure
Term
What triggers signals the brain to increase the output of ADH for water conservation
Definition
Osmoreceptors in the hypothalamus detect tphe increase in osmotic pressure of body fluids and signal the posterior pituitary to release ADH
Term
How does alcohol function as a diuretic
Definition
Alcohol inhibits the release of ADH and thus urine output is increased
Term
The hormone aldosterone regulates the concentrations of ______________ and ________________ in the body
Definition
Potassium ions; sodium ions
Term
An abnormal accumulation of interstitial fluid is termed
Definition
edema
Term
What is the purpose of negative feedback
Definition
to restore a regulated variable to homeostasis if disturbed
Term
How is negative feedback generally accomplished
Definition
reflex arcs
Term
What are reflex arcs
Definition
homeostatic control systems that sense and respond to changes in the ECF
Term

Put the components of a reflex arc in order

 

Effector organ

Sensory receptor

Integration center

Stimulus

Response

Definition

Stimulus

Sensory Receptor

Integration Center

Effector Organ

Response

 

Response feeds back to receptor to stop pathway when goal is accomplished (negative feedback inhibition)

Term
Sensory receptor
Definition

detects change or stimulus

 

Afferent Pathway Input

Term
Integration Center
Definition

receives and processes information from receptor

 

Efferent Pathway/Output

Term
Effector Organ
Definition
Responds to command from control center
Term
Increases the speed of the body's homeostatic responses and minimizes fluctuations in variable being measured
Definition
Feedforward Mechanisms
Term
Extrinsic
Definition
  • Slower
  • Can accomplish more
  • Uses the Endocrine System or Nervous System
  • Needs help from another part of the body
  • Long distance communcation
Term
Extrinsic
Definition

Involves the nervous and/or endocrine system detecting a change and sendig a signal or releasing a chemical to facilitate change in another organ system, organ, or cell

 

Term
Intrinsic
Definition

Auto regulation

 

When a cell, organ, or organ system automatically adjusts itself in response to a change in the environment

Term

Chemical equation

 

acid base balance

Definition

↑   CO2 + H2O -> H2CO3 -> ↑ H+ + HCO3-

 

 

This equation lowers pH which causes cell respiration to increase

Term
Cells generate CO2 as a waste product of
Definition
metabolism
Term
CO2 + H2O makes
Definition
carbonic acid (H2CO3)
Term
Carbonic acid dissociates to
Definition
bicarbonate ion (HCO3- and hydrogen ion (H+)
Term

Does more hydrogen ions raise or lower pH

 

which causes respiration rate to increase or decrease

Definition

Lower

 

Increase

Term
Extracellular buffers include
Definition
bicarbonate and ammonia
Term
Intracellular buffers
Definition
proteins and phosphate
Term
If the blood pH drops too low acidemia, the body will compensate by
Definition
increasing breathing, expelling CO2 and shifting the reaction to the right - less hydrogen ions are free to bind
Term
If the blood pH raises to high (alkalemia), the body will compensate by
Definition
decreasing breathing, holding onto CO2, and shifting the reaction to the left so more hydrogen ions are free to bind
Term

A mechanisms that is designed to push levels out of normal ranges

 

A series of events initiates a cascading process that builds to increase the effect of the stimulus

Definition

Positive Feedback

 

Ex:  blood clotting

      Release of oxytocin -  to intensify the contractions that take place during childbirth

Term
A mechanism that reduces the output or activity of any organ or system back to its normal range of function
Definition

Negative Feedback

 

Ex:  Blood pressure - Sense resistance of blood flow blood vessels act as receptors which sends a message to the effectors organs - brain and heart.  heart rate decreases, blood vessels vasodilate, blood pressure falls back to normal range

Body Temperature

 

Term
Maintenance of a regulated variable within a healthy range, requires energy
Definition

Steady-state

 

Homeostasis

Term

Bodily processes related to homeostasis

 

 

Pacemaker of circadian rhythms

Definition

Hypothalamus

 

  • Receives input from eyes and other sensory parts of the body
  • Regulates the pineal gland - secretes melatonin during darkness

 

 

Term

Involved in regulating

Sleep/wake

Body temperature

Hormone concentrations

Anticipatory Homeostasis (feedforward)

Definition
Hypothalamus
Term
How do cells become specialized to communicate with one another in order to maintain homeostasis
Definition

Chemical messengers

target cells with receptors

signal transduction pathways

target cell response pathway

Term
Long range chemical messengers
Definition
Hormone
Term
chemical messengers that communicate to adjacent cells
Definition
Neurotransmitter
Term
A chemical messenger that has a protein sequence which acts as a homone or neurotransmitter 
Definition
neuropeptide
Term
A given hormone usually affects only a limited number of cells, which are called
Definition

target cells

 

A target cell responds to a specific hormone because it bears a receptor for that hormone

Term
A hormone that is distributed in blood and binds to distant target cells
Definition
Endocrine
Term
A hormone that acts locally by diffusing from its source to target cells in the neighborhood
Definition
Paracrine
Term
A hormone that acts on the same cell  that produced it
Definition
Autocrine
Term
Messengers that are released into the ECF and bridge the gap between cells
Definition
Chemical messengers
Term
Chemicals that are secreted by endocrine organs, travel in the blood plasma, and act on target cells with receptors
Definition
Hormones
Term

Allow for communication at synapses

Communication is faster, but shorter lived

Do not go into bloodstream

Released into the interstitial fluid

Definition
Neurotransmitters
Term

Cells within a tissue communicate with other cells in the same tissue

Low concentration of chemicals secreted into interstitial fluid, and diffuse to their receptors

 

Definition
Paracrine
Term
Can paracrine chemicals act like hormones
Definition

Yes, if they travel through the bloodstream

 

Ex :  interleukins, interferons

Term
A major category of paracrine agents derived from arachidonic acid, a constituent of plasma membrane phospholipids
Definition
eicosanoids
Term

Paracine chemicals produced by WBCs

Involved in inflammation and immune response fo the injured tissue

Definition
Leukotrienes
Term
Involved in blood clotting
Definition

Prostacyclins

Thromboxanes

Term

Paracrine chemicals produced by almost all cells

raise/lower local BP

decrease gastric secretion

enhance the inflammation response

dilate/constrict bronchioles

contract/relax smooth muscle

shrink nasal membranes

cause sedation

cause fever

Definition
Prostaglandins
Term
Blocks the synthesis of eicosanoids and prostaglandins
Definition
aspirin and NSAIDs
Term
Block the synthesis of all eicosanoids, inhibit phosphlipase A2
Definition
Adrenal steroids or corticosteriods
Term

Direct communication throug gap junctions

Does need to use intercellular chemical messengers

Allows instantaneous communication between cells

Cells may function as a single entity

 

Definition
Autocrine
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