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Chapter 1 & 2
flashcards
25
Other
Not Applicable
04/11/2005

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Cards

Term
Two types of data collection
Definition
randomized experiment and observational study
Term
Randomized experiments can prove
Definition
causation
Term
Salk vaccine field trial
Definition
randomized controlled double-blind experiment
Term
Portacaval shunt studies (liver surgery)
Definition
assignment to control group was not randomized
Term
Did the the four therapy studies use historical controls
Definition
Yes
Term
What are historical controls
Definition
patients treated the old way in the past
Term
Trials with historical controls are
Definition
biased
Term
randomized controlled experiments are good and minimize what
Definition
confounding problem
Term
what is confounding
Definition
a third variable associated with exposure to disease (confusing factors)
Term
observational studies establish what
Definition
association, and can be misleading
Term
which type of study is best: observational or randomized experiment
Definition
randomized controlled experiment
Term
observational study: Clofibrate trial (coronary drug project)
Definition
randomized control double blind experiment- some patients didn’t take the medications to lower cholesterol
Term
Pellagra (fly vs niacin)
Definition
association is not causastion
Term
Cervical Cancer
Definition
presence of confounding factors (sexually transmitted disease)
Term
Ultrasound and low birth rate
Definition
only an observational study
Term
Treatment Group is given the
Definition
medicine
Term
Control Group is given the
Definition
placebo
Term
What does comparing these two groups mean?
Definition
The difference in the response is due to the treatment
Term
Why is a placebo neutral and why should it resemble the treatment
Definition
the response should be due to the treatment itself rather than the idea of the treatment
Term
What is double blinding
Definition
neither the investigator or the subject know who is the treatment group and who is the control group
Term
Does the investigator or the subject have the power to assign subjects in an observational study
Definition
NO
Term
What is association
Definition
one thing linked to another
Term
What is causation
Definition
on overall outcome due to something for example exposure to disease
Term
How good is observational studies
Definition
can be misleading
Term
The weakness of observational studies is
Definition
confounding factors
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