Term
|
Definition
~ Building Blocks of Proteins
~a central C atom with substituents (NH3+, COOH-, H) and the R group that gives it its name
[image] |
|
|
Term
|
Definition
| Molecule bearing groups with opposite charge. Ex: COO- will be protonated; NH3+ will be deprotonated |
|
|
Term
Stereochemistry...
All amino acids in proteins exist as the ___ isomer.
They are: chiral or achiral? |
|
Definition
All amino acids in proteins exist as the L isomer.
They are chiral, meaning nonsuper-imposable. |
|
|
Term
| Nonpolar Aliphatic Side Chains? |
|
Definition
| Glycine (is the only one not chiral), Alanine, Proline (contains N), Valine, Leucine, Isoleucine, Methionine (contains S) |
|
|
Term
| Aromatic Side Chain groups |
|
Definition
| Phenylaline (most hydrophobic), Tyrosine (contains -OH/phenol), Tryptophan (contains multiple rings) |
|
|
Term
| Polar, Uncharged Side chains |
|
Definition
Serine, Threonine, Cysteine (contains S). Also, Asparagine & Glutamine, which both contain an amide R-group.
*ALL act as e- donors/acceptors |
|
|
Term
| Disulfide Bonds are formed by: |
|
Definition
| Cysteine. This is in reduced and oxidized formations. |
|
|
Term
| Acidic (- charged) Side Chains |
|
Definition
Aspartate & Glutamate (contains 1 extra carbon)
In solid state, is acidic, once dissolved, proton falls off, therefore (-) charged. |
|
|
Term
| Basic (+ charged) Side Chains |
|
Definition
| Lysine (large 4C chain with amine that's protonated), Arginine (has C=NH2), & Histidine |
|
|
Term
|
Definition
| pH where there is no net charge |
|
|
Term
| _________ contains a side chain most likely to be found in the interior of a protein? |
|
Definition
|
|
Term
| ___________ has a side chain that is mostly charged at pH = 8 |
|
Definition
|
|
Term
| ___________ has a side chain that contains a nitrogen atom. |
|
Definition
|
|
Term
| This amino acid contains an –R group that is a hydrogen bond acceptor at pH 8. |
|
Definition
|
|
Term
For lysine, pK1=2.18, pK2=8.95, pK3=10.53
What is the pI? |
|
Definition
|
|
Term
| What amino acid is not commonly found in the hydrophobic core of a protein domain? |
|
Definition
|
|
Term
|
Definition
|
|
Term
Shown below is the titration curve for a different amino acid. The pKa of the side chain (i.e. the R group) of this amino acid is approximately ____
[image] |
|
Definition
|
|
Term
Given the following titration curve of Arg, the pI of Arg is approximately (use the pKas, etc. of this titration curve):
[image] |
|
Definition
|
|
Term
|
Definition
Alanine
Ala
A
nonpolar
side chain charge: neutral |
|
|
Term
|
Definition
Arginine
Arg
R
polar
side chain charge: + |
|
|
Term
|
Definition
Asparagine
Asn
N
polar
Side chain charge: neutral |
|
|
Term
|
Definition
Aspartic Acid
Asp
D
polar
Side chain charge: - |
|
|
Term
|
Definition
Cysteine
Cys
C
nonpolar
Side chain charge: neutral |
|
|
Term
|
Definition
Glutamic Acid
Glu
E
polar
Side chain charge: - |
|
|
Term
|
Definition
Glutamine
Gln
Q
polar
Side chain charge: neutral |
|
|
Term
|
Definition
Glycine
Gly
G
nonpolar
side chain charge: neutral |
|
|
Term
|
Definition
Histidine
His
H
polar
Side chain charge: mostly neutral, slightly + |
|
|
Term
|
Definition
Isoleucine
Ile
I
nonpolar
side chain charge: neutral |
|
|
Term
|
Definition
Leucine
Leu
L
nonpolar
side chain charge: neutral |
|
|
Term
|
Definition
Lysine
Lys
K
polar
side chain charge: + |
|
|
Term
|
Definition
Methionine
Met
M
nonpolar
neutral side chain |
|
|
Term
|
Definition
Phenylalanine
Phe
F
nonpolar
neutral side chain |
|
|
Term
|
Definition
Serine
Ser
S
polar
neutral side chain |
|
|
Term
|
Definition
Threonine
Thr
T
polar
neutral side chain |
|
|
Term
|
Definition
Tryptophan
Trp
W
nonpolar
neutral side chain |
|
|
Term
|
Definition
Tyrosine
Tyr
Y
polar
neutral side chain |
|
|
Term
|
Definition
Valine
Val
V
nonpolar
neutral side chain |
|
|
Term
|
Definition
Proline
Pro
P
nonpolar
neutral side chain |
|
|
