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Ch. 23 Developmental Genetics
Genetics: Analysis and Principles
35
Biology
Undergraduate 2
10/18/2011

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Term
pattern
Definition
spatial arrangement of different regions of the body
Term
positional information
Definition
signals received by cell that cause it to become the appropriate cell type based on its position relative to the other cells
Term
apoptosis
Definition
regulated cell death
Term
morphogen
Definition
molecule that conveys positional information and promotes developmental changes over time
Term
induction
Definition
process by which cell(s) governs the developmental fate of neighboring cells
Term
cell adhesion
Definition
cells' ability to attach to other cells and the cellular matrix to transmit information
Term
cell adhesion molecules (CAMs)
Definition
surface receptors generated by the cell to make contact with other cells
Term
homeotic gene
Definition
gene that plays central role in specifying final identity of body region; mutations result in wrong body part in a location
Term
bilaterians
Definition
animals exhibiting a left-right symmetry (anteriorpoterior and dorsalventral axes)
Term
formation of body axes, segmentation of body, determination of structures, cell differentiation
Definition
4 developmental stages of bilaterians
Term
determination
Definition
groups of cells becoming destined to develop into particular structures/types
Term
Drosophila melanogaster
Definition
model organism for invertebrate bilaterian development
Term
oocyte
Definition
cell most critical in determining the pattern of development in the adult organism; has preestablished axes
Term
blastoderm
Definition
formed after fertilization and early nuclear division; a sheet of cells on the outside with the yolk in the center
Term
pole cells
Definition
form at posterior end of blastoderm; germ cells that eventually become gametes in adult organism
Term
gastrulation
Definition
stage of embryonic development where cells divide into ectoderm, mesoderm, and endoderm
Term
parasegments
Definition
14 transient subdivisions in the embryo where gene expression is controlled spatially
Term
segments
Definition
after parasegments disappear, morphologically distinct divisions appear
Term
embryogenesis
Definition
formation and segmentation of the embryo
Term
metamorphosis
Definition
post-hatching developmental stage, takes place in pupa
Term
imaginal disks
Definition
cells present in larva that differentiate during metamorphosis into distinct structures in the adult fly
Term
anteroposterior axis
Definition
head to tail (quadrapeds)
Term
dorsoventral axis
Definition
back to belly
Term
proximodistal axis
Definition
usually for designating limb parts; near to far
Term
left/right axis
Definition
occurs relative to anteroposterior axis, depending on stature of animal
Term
nurse cells
Definition
in female Drosophila, gene products are transferred from these cells to oocytes via cytoplasmic bridges
Term
segmentation genes
Definition
gap, pair-ruled, and segment polarity genes that cause particular regions of the embryo to become segmented in particular ways
Term
zygotic genes
Definition
genes expressed after fertilization
Term
cell fate
Definition
ultimate morphological features that a cell adopts
Term
homeotic mutant
Definition
mutants in which one body part is replaced by another (ie a leg on the head instead of antenna)
Term
gain-of-function mutation
Definition
mutation that results in the addition of qualities, like the Antennapedia mutation
Term
loss-of-function mutation
Definition
a mutation that deletes or renders inert a particular structure
Term
homeobox
Definition
coding sequence of homeotic genes with a 180bp consensus sequence that codes for transcription factors
Term
homeodomain
Definition
protein domain encoded by a particular homeobox, usually a transcription factor
Term
lineage diagram
Definition
method of presenting cell division as it progresses
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