Term
| What drug suppress bacterial growth by inhibiting synthesis of folic acid |
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Definition
| Sulfamethoxazole (its a sulfonamide) |
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Term
| What is Sulfamethoxazole primarily used to treat? |
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Definition
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Term
| What are the adverse effects of Sulfamethoxazole? |
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Definition
| Hypersensitivity that can be mild or severe(Stevens-Johnsons); Hematologic effects, Kernicterus, photosensitivity, renal damage from crystalluria (8-10 glasses of water each day. |
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Term
| What medication do you want to check allergies with sulfa? |
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Definition
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Term
| Which medication suppresses bacterial synthesis of DNA, RNA, and proteins by inhibing dihydrofolate reductase? |
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Definition
| Trimethoprim (cidal or static) |
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Term
| What are the adverse effects of Trimethoprim? |
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Definition
Itching, rash, GI- N/V,
hematologic effects- megaloblastic anemia, thrombocytopenia, neutropenia |
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Term
| What is Trimethoprim + Sulfamethoxazole called? |
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Definition
| Bactrim or Septra (additive) |
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Term
| Theraputic uses of Bactrim include: |
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Definition
UTI is #1
Pneumocystis pneumonia(PCP) in HIV pts
GI infections, MRSA of skin, otitis media, bronchitis, whooping cough, mocardiosis, brucellosis, meliodosis, chancroid |
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Term
| Bactrim is generally well tolerated. Some of the adverse effects are: |
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Definition
| nausea, vomiting, and rash; same effects as with two drugs separately, photosensitivity, Hypersensitivity reactions including Stevens-Johnson Syndrome, Hematologic problems- hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia, Kernicterus, renal damage |
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