Term
| P. Falciparum initially infests what organ in humans |
|
Definition
| Liver, until release of parasites into blood stream |
|
|
Term
| P. Falciparum infects what type of cells in humans? |
|
Definition
| Liver then RBC leading to lysis |
|
|
Term
| Tissue hypoxia, sludged RBC, hemmorage and necrosis |
|
Definition
|
|
Term
| Involve only 1 cycle of liver cell invasion |
|
Definition
| P. falciparum and P. malariae |
|
|
Term
| Involve multiple cycles of hepatic forms |
|
Definition
|
|
Term
| if not polymerizaed lysosomal damage to RBC occurs |
|
Definition
|
|
Term
|
Definition
| inhibit heme polymerization |
|
|
Term
| Primaquine and Atovaquone |
|
Definition
| block ubiquinone from donating electrons to cyochrome bc1 complex, preventing the regeneration of DHOD |
|
|
Term
|
Definition
| binds to ferriprotoporphyrin IX and inhibits polymerization |
|
|
Term
|
Definition
pruritus in African americans, exacerbate psoriasis and porphyria,
In larege amounts: vomiting, retinopathy, hypotension, confusion death (Suicide) |
|
|
Term
| Chloroquine treats what stage of malarial infections |
|
Definition
|
|
Term
|
Definition
| blocks heme polymers and inserts into DNA |
|
|
Term
|
Definition
| "Cinchonism"-Deafness, headaches, nausea, visual disturbances, DIC, Long QT, HUS, Rash, GI issues |
|
|
Term
| Quinine and Quinidine should never be used with |
|
Definition
|
|
Term
|
Definition
| Blood only, no prophylactic |
|
|
Term
|
Definition
| Chloroquine resistant malaria |
|
|
Term
|
Definition
| seizures, vivid dreams, heart issues, GI issues and dizzyness |
|
|
Term
| Artemisinin, artesunatem artemether, dihydroartemisinin |
|
Definition
| decreases transmission of malaria in infected individuals and in blood |
|
|
Term
|
Definition
| attacks hepatic forms of malaria (vivax and ovale) |
|
|
Term
|
Definition
| disrupts mitochondria in plasmodia thru interferance with ubiquinone as electron carrier in respitory chain |
|
|
Term
| Never use Primaquine with what disease |
|
Definition
| G6PD due to massive hemolysis |
|
|
Term
| Primaquine can not be given to who? |
|
Definition
| Pregnant women because it crosses the placenta |
|
|
Term
|
Definition
| inhibits uqiquinone and cytochrome bc1 complex interaction |
|
|
Term
| atovaquone is given in conjunction with |
|
Definition
|
|
Term
| doxycycline and tetracycline |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| inhibit folate metabolism |
|
|
Term
| sulfadoxine-pyrimethamine |
|
Definition
| Steven Johnson tcp nephrotoxicity |
|
|
Term
|
Definition
| inhibitor of dihydrofolate reducatase |
|
|
Term
| Metronidazole, Tinidazole |
|
Definition
| activated to damage microbial proteins membranes and DNA |
|
|
Term
|
Definition
| inhibits pyruvate ferredoxin oxidoreductase |
|
|
Term
| Metronidaxole and tinidazole |
|
Definition
| anaerobic bacteria, amebiasis, giardiasis, trichomoniasis |
|
|
Term
|
Definition
| giardiasis, cryptosporidiosis |
|
|
Term
|
Definition
| African trypanosomiasis and pneumocystis carini |
|
|
Term
|
Definition
| inhibits DNA, RNA, protein and phospholipid synthesis |
|
|
Term
|
Definition
| African trypanosomiasis early stage |
|
|
Term
|
Definition
| inhibits RNA Polymerase and glycerol phosphate dehydrogenase |
|
|
Term
|
Definition
| Late stage african trypansomiasis (CNS) |
|
|
Term
|
Definition
| blocks pryvate kinase, and inhibits adenine and adenosine uptake |
|
|
Term
|
Definition
| West african trypanosomiasis |
|
|
Term
|
Definition
| inhibits ornithine decarboxylase |
|
|
Term
|
Definition
|
|
Term
|
Definition
| generate intracellular oxygen radicals |
|
|
Term
| Sodium stubogluconate and meglumine antimonate |
|
Definition
|
|
Term
| Sodiumm stibogluconate and meglumine antimonate |
|
Definition
| inhibit glycolysis and FA oxidation |
|
|
Term
|
Definition
| Oral leishmaniasis and skin cancer |
|
|
Term
|
Definition
| inhibits plasma membrane enzymes PLC |
|
|
Term
|
Definition
| Onchocerciasis, filariasis, strongyloidiasis, scabies, cutaneous larva |
|
|
Term
|
Definition
| potentiated Cl channels and release of GABA from presynapse leading to neuromuscular parylasis |
|
|
Term
| Albendazole, Mebendazole, Thiabendazole |
|
Definition
| Nematode, cysticercoisis, echinococcosis |
|
|
Term
| Albendazole, Mebendazole, Thiabendazole |
|
Definition
| inhibits tubulin polymerization |
|
|
Term
|
Definition
| increase Ca permeability leading to paralysis of worms |
|
|
Term
|
Definition
| schistomiasis, tapeworm and liver fluke |
|
|
Term
|
Definition
| unknown, stimulate immune system? |
|
|
Term
|
Definition
| Filariasis and is Curative* |
|
|
Term
|
Definition
| pinworm, roundworm, and hookworm |
|
|
Term
|
Definition
| causes constant release of ACH leading to tonic paralysis |
|
|
Term
|
Definition
| Gaba agonist leading to flaccid paralysis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Reactive encephalopathy, highly toxic to hums, phlebitis, polyneuropathy |
|
|
Term
| Sodium stubogluconate and meglumine antimonate |
|
Definition
| BM supression, pancreatitis, rash, prolongued QT |
|
|
