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Ch 2 & 3
Cell Function and Growth
103
Pathology
Graduate
08/24/2025

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Term
Prokaryotic Cells
Definition
single cell organisms; bacteria
Term
Eukaryotic Cells
Definition
cells that have organelles (internal membrane bound compartments that have specific functions)
Term
What three functional cell components do all eukaryotic cells have?
Definition
nucleus, cytoplasm, cell membrane
Term
What is cytoplasm?
Definition
intra cellular fluid
Term
What is cytoplasm made up of?
Definition
water, proteins, carbs, and electrolytes
Term
Where are the instructions to create proteins stored within a cell?
Definition
inside the nucleus
Term
What are the 3 main types of RNA?
Definition
messenger, ribosomal, and transfer
Term
What are the lengths of DNA that code for specific proteins?
Definition
genes
Term
This complementary single stranded RNA molecule leaves the nucleus and moves to the cytoplasm where proteins are made
Definition
messenger RNA (mRNA)
Term
Which organelle reads the base sequence of mRNA during protein synthesis?
Definition
ribosome
Term
A ribosome uses the genetic code to translate each three-base triplet, or codon, into its corresponding _________?
Definition
amino acid
Term
What is a genetic code or base triplet?
Definition
codon
Term
What forms part of the protein-synthesizing organelle that is exported to the cytoplasm to help translate the information in mRNA into protein?
Definition
ribosomal RNA (rRNA)
Term
What is the site of protein production?
Definition
ribosomal RNA (rRNA)
Term
What are temporary carriers of amino acids, bringing the appropriate amino acids to the ribosome based on the mRNA nucleotide sequence?
Definition
transfer RNA (tRNA)
Term
Membrane bound organelle that contains the DNA.
Definition
nucleus
Term
Organelle that extends from pores of the nuclear membrane, has many folds, helps materials get around the cell, and holds some of the ribosomes?
Definition
endoplasmic reticulum (ER)
Term
What organelle receives assembled items from the endoplasmic reticulum, modifies sorts and packages the materials for delivery. Much like a packaging facility.
Definition
golgi apparatus
Term
What organelle is the powerhouse of the cell?
Definition
mitochondria
Term
Where is ATP produced?
Definition
mitochondria
Term
Which organelle have their on DNA?
Definition
mitochondria
Term
Which organelle contains enzymes that help break things down such as pathogens?
Definition
lysosomes
Term
Which organelle is a large set of proteins that act as a wood chipper, degrading proteins?
Definition
proteasome
Term
What is the difference between rough and smooth endoplasmic reticulum?
Definition
ribosome are attached to rough ER not smooth ER
Term
In which organelle does cellular respiration occur?
Definition
mitochondria
Term
What serves as a semipermeable barrier for the cell made up of a lipid bilayer?
Definition
cell membrane
Term
The cell membrane is made up of a phospholipid bilayer with a __________ head and a __________ tail.
Definition
hydrophilic / hydrophobic
Term
What is the exterior of the cell membrane that participates in cell to cell recognition and adhesion?
Definition
glycocalyx
Term
What is the importance and function of cholesterol in a cell membrane?
Definition
they mediate spacing of the phospholipids keeping them from bunching too close together or spreading too far apart
Term
What are proteins called that are located on the outer part of the cell membrane?
Definition
peripheral proteins
Term
What are proteins called that go through the cell membrane?
Definition
integral proteins
Term
Which proteins aid with transporting things in and out of the cell such a glucose?
Definition
integral proteins
Term
Which cell communication is a cell speaking to itself?
Definition
autocrine
Term
Which cell communication acts on nearby cells?
Definition
paracrine
Term
Which cell communication relies on hormones carried in the bloodstream to cells throughout the body?
Definition
endocrine
Term
Which cell communication occurs in the nervous system, where neurotransmitters act only on adjacent nerve cells?
Definition
synaptic
Term
Which chemicals have a hard time getting into the cell and typically rely on surface receptors?
Definition
hydrophilic
Term
What cell receptor is the on-off switch for signal transduction?
Definition
G-protein linked receptors
Term
What cell receptor is characterized by rapid synaptic signaling between electrically excitable cells. i.e. transmission of impulses in nerve and muscle cells
Definition
Ion channel-linked receptors
Term
Which cell receptors are for certain protein hormones? i.e. activate an intracellular domain with enzyme activity (cell growth, proliferation, differentiation)?
Definition
enzyme-linked receptors (catalytic receptors)
Term
A signal molecule is called a _____?
Definition
ligand
Term
Ligands that move directly across the cell membrane bind to what?
Definition
intracellular receptors
Term
Which drugs distribute through the cell membrane with preference for adipose tissue and muscle (greater volume of distribution)?
Definition
lipophilic
Term
Which drugs remain mostly in blood compartments until they are eliminated?
Definition
hydrophilic
Term
A (increase or decrease) in the volume distribution of a drug will generally increase its elimination half-life.
Definition
increase
Term
A (increase or decrease) in volume of distribution with an increase in elimination clearance will generally decrease elimination half-life of a drug.
Definition
decrease
Term
Most receptors on the surface of cell membranes are what?
Definition
proteins
Term
The process by which fats, proteins, and carbs from foods we eat are converted into energy in the form of ATP
Definition
metabolism
Term
Metabolism that consists of breaking down stored nutrients and body tissues to produce energy. (aerobic and anaerobic production of ATP)
Definition
Catabolism
Term
Metabolism that is a constructive process in which more complex molecules are formed from simpler ones. (bone growth or building muscle mass)
Definition
anabolism
Term
Chemicals that bind to receptor proteins, that can be hormones or medications or other chemicals, are all in a group called what?
Definition
ligands
Term
What are the three types of passive transport?
Definition
diffusion, osmosis, facilitated diffusion
Term
Type of passive transport where molecules move freely across the membrane from areas of high concentration to areas of low concentration.
Definition
diffusion
Term
The "grown up" name for water channels.
Definition
aquaporins
Term
The facilitation of water across the cell membrane via aquaporins.
Definition
osmosis
Term
Passive transport that requires a carrier mechanism to cross the membrane.
Definition
facilitated diffusion
Term
Pumps involved in active transport across the cell membrane require what?
Definition
ATP
Term
What are the two types of active transport across the cell membrane?
Definition
primary and secondary
Term
Secondary transport across the cell membrane has two subtypes.
Definition
symport and antiport
Term
Secondary active transport that moves substances in the same direction.
Definition
symport
Term
Secondary active transport that moves substances in opposite directions.
Definition
antiport
Term
What are the two types of endocytosis for transport across the cell membrane?
Definition
phagocytosis and pinocytosis
Term
This is the process of a molecule engulfing a substance, such as a pathogen or debris, and transporting it out of the cell.
Definition
phagocytosis
Term
Process by which the cell membrane creates a vesicle that brings nutrients into the cell.
Definition
pinocytosis
Term
Process by which the cell membrane creates a vesicle that moves unwanted material out of the cell.
Definition
exocytosis
Term
What are the three types of gated ion channels?
Definition
ligand-gated, voltage-gated, and mechanically gated
Term
This ion channel is activated when a signal molecule of some kind attaches to the channel.
Definition
ligand gated
Term
This ion channel is activated by a physical stimulus.
Definition
mechanically gated
Term
This ion channel is activated by electrical changes.
Definition
voltage gated
Term
Which two ion channels can be involved in initial depolarization prior to reaching threshold levels?
Definition
ligand gated and mechanically gated
Term
[image]
Definition
action potential
Term
What are the stages of action potential?
Definition
resting state, depolarization, repolarization, hyperepolarization
Term
What is the point called where depolarization spikes toward the peak?
Definition
threshold
Term
Cells organized by their structures or function into ______.
Definition
tissues
Term
What are the four types of tissues?
Definition
epithelial, connective, neural, muscle
Term
This type of tissue covers the outer body surface, lines internal surfaces, and forms glandular tissue. Is basically avascular.
Definition
epithelial
Term
What are the three classifications of epithelial tissue based on layers present?
Definition
simple, stratified, pseudostratified
Term
What are the three classifications of epithelial tissue based on shape?
Definition
squamous, cuboidal, columnar
Term
[image]
Definition
epithelial tissue
Term
Which is the most abundant tissue in the body?
Definition
connective tissue
Term
Tissue that binds or supports the various tissue.
Definition
connective tissue
Term
Three types of muscle tissue.
Definition
cardiac, smooth, skeletal
Term
Cardiac muscles have two types.
Definition
Autorhythmic and smooth
Term
Two types of nervous tissue.
Definition
neurons and glial
Term
Which nervous tissue functions in communication?
Definition
neurons
Term
What receive and carry stimuli in nervous tissue?
Definition
dendrites
Term
What generates and conducts action potentials in nervous tissue?
Definition
axons
Term
What stores neurotransmitters in vesicles in nervous tissue?
Definition
axon terminals
Term
What is the function of glials in nervous tissue?
Definition
to support the neurons
Term
Cell adaption that is a decrease in size.
Definition
atrophy
Term
cell adaption that is an increase in size.
Definition
hypertrophy
Term
cell adaption that is an increase in number
Definition
hyperplasia
Term
cell adaption that is the replacement of adult cells
Definition
metaplasia
Term
cell adaption that is a deranged cell growth of a specific tissue
Definition
dysplasia
Term
potassium always wants to be __________ the cell
Definition
inside
Term
sodium always wants to be _________ the cell
Definition
outside
Term
Are atoms that contain unpaired electrons
Definition
free radicals
Term
Molecules that donate electrons to free radicals
Definition
antioxidants
Term
The process where a hypoxic cell is attacked by free radicals and the reintroduction of oxygen to a cell depleted of antioxidants exacerbates the free radical attack
Definition
reperfusion injury
Term
programmed cell death
Definition
apoptosis
Term
highly selective process that controls tissue regeneration, is important in embryonic development, and eliminates cells that are worn out, have been produced in excess, have developed improperly, or have genetic damage
Definition
apoptosis
Term
cell death in a living organ or tissues
Definition
necrosis
Term
occurs when a considerable mass of tissue undergoes necrosis
Definition
gangrene
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