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Ch 19
Test
67
Biochemistry
Undergraduate 3
04/13/2015

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Term
Glycolysis occurs in
Definition
The cytosol
Term
Citric Acid Cycle occurs in
Definition
Mitochondrial matrix
Term
Conversion of pyruvate to Acetyl-CoA requires
Definition
NAD+
Term
Conversion of pyruvate to acetyl-CoA produces
Definition
NADH + H+ + CO2
Term
What facilitates the conversion of CoA-SH to CO2 in the conversion of pyruvate to Acetyl-CoA?
Definition
Pyruvate dehydrogenase complex
Term
Conversion of pyruvate to acetyl-CoA requires what coenzymes?
Definition
TPP, FAD, Mg2+, and lipoic acid
Term
What transports pyruvate into the mitochondria?
Definition
Pyruvate Dehydrogenase Complex
Term
Pyruvate Dehydrogenase Complex consists of...
Definition
Pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase, pyruvate dehydrogenase kinase, and pyruvate dehydrogenase phosphotase
Term
Which enzymes in the pyruvate dehydrogenase complex convert pyruvate to acetyl CoA?
Definition
Pyruvate dehydrogenase, dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase
Term
Which enzymes in the pyruvate dehydrogenase complex are control enzymes?
Definition
Pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase
Term
First step of conversion of pyruvate to acetyl-CoA: BLANK is converted to BLANK and BLANK is lost
Definition
Pyruvate, HETPP, CO2
Term
Second step of conversion of pyruvate to acetyl-CoA: BLANK is transferred to BLANK and oxidized to form BLANK
Definition
Hydroxyethyl group, lipoic acid, acetyl dihydrolipoamide
Term
Third step of conversion of pyruvate to acetyl CoA: BLANK is transferred to BLANK
Definition
Acetyl group, CoA
Term
Fourth step of conversion of pyruvate to acetyl CoA: BLANK is reoxidized
Definition
Dihyrolipoamide
Term
How many steps are required to convert pyruvate to acetyl CoA?
Definition
Four
Term
Which enzyme is responsible for step 1 of the conversion of pyruvate to acetyl CoA?
Definition
Pyruvate dehydrogenase
Term
Which enzyme is responsible for step 2 of the conversion of pyruvate to acetyl CoA?
Definition
Dihydrolipoyl transacetylase
Term
Which enzyme is responsible for step 3 of the conversion of pyruvate to acetyl CoA?
Definition
Dihydrolipoyl transacetylase
Term
Which enzyme is responsible for step 4 of the conversion of pyruvate to acetyl CoA?
Definition
Dihydrolipoyl dehydrogenase
Term
Step 1 of the citric acid cycle: BLANK and BLANK are converted to BLANK and BLANK
Definition
Acetyl-CoA, Oxaloacetate, Citrate, CoA-SH
Term
Enzyme of step 1 of the citric acid cycle
Definition
Citrate synthase
Term
Step 1 of the citric acid cycle is (endergonic/exergonic)
Definition
Exergonic
Term
Step 2 of the citric acid cycle converts BLANK to BLANK
Definition
Citrate, Isocitrate
Term
Enzyme of step 2 of the citric acid cycle
Definition
Aconitase
Term
Coenzyme of step 2 of the citric acid cycle
Definition
Fe2+
Term
Step 2 converts a BLANK compound to a BLANK compound
Definition
Achiral, chiral
Term
What is special about flouracetyl CoA?
Definition
Alternative substrate to acetyl CoA, is converted to flourocitrate which inhibits aconitase is step 2 (poisonous plants)
Term
In step 3 of the citric acid cycle BLANK and BLANK are converted to BLANK and BLANK
Definition
Isocitrate, NAD+, NADH Oxalosuccinate
Term
BLANK is required for step 3
Definition
NAD+
Term
In step 3 of the citric acid cycle BLANK is oxidized to BLANK and BLANK is lost
Definition
Oxalosuccinate, Alpha-keroglutarate, CO2
Term
Enzyme of step 3
Definition
Isocitrate dehydrogenase
Term
In step 4 of the citric acid cycle BLANK, BLANK and BLANK are converted to BLANK, BLANK and BLANK
Definition
Alpha-keroglutarate, NAD+, CoA-SH, Succinyl-CoA, NADH+ and CO2
Term
Step 4 of the citric acid cycle is (exergonic/endergonic)
Definition
Exergonic
Term
Coenzymes needed in step 4 of the citric acid cycle
Definition
Mg2+, TPP, Lipoic Acid and FAD
Term
Enzyme of step 4
Definition
Alpha-glutarate dehydrogenase complex
Term
In step 5 of the citric acid cycle BLANK and BLANK are converted to BLANK, BLANK and BLANK
Definition
Succinyl-CoA, GDP, Succinate, GTP, and CoA-SH
Term
Where does the energy for step 5 come from?
Definition
Hydrolysis of succinyl-CoA to CoA-SH
Term
When can ATP be made without the ETC?
Definition
Step 5: GTP is converted to ATP by nucleosidediphosphate kinase
Term
Synthetase (does/does not) require energy
Definition
Does
Term
Which part of step 5 is endergonic?
Definition
Creation of GTP
Term
Enzyme of step 5
Definition
Succinyl CoA sythetase
Term
In step 6 of the citric acid cycle BLANK and BLANK are converted to BLANK and BLANK
Definition
Succinate, FAD, FADH2, Fumarate
Term
Which step of the citric acid cycle occurs in the inner mitochondrial membrane?
Definition
Step 6
Term
Coenzymes for step 6
Definition
Fe and S
Term
Enzyme of step 6 of the citric acid cycle
Definition
Succinate dehydrogenase
Term
What is special about succinate dehydrogenase?
Definition
Integral protein in the inner mitochondrial membrane
Term
In step 7 of the citric acid cycle BLANK and BLANK are converted to BLANK
Definition
Fumarate, H2O, L-Malate
Term
Enzyme of step 7
Definition
Fumerase
Term
In step 8 of the citric acid cycle BLANK and BLANK are converted to BLANK and BLANK
Definition
L-Malate, NAD+, NADH, Oxaloacetate
Term
Enzyme used in step 7 of the citric acid cycle
Definition
Malate dehydrogenase
Term
Total # of molecules of CO2 lost in citric acid cycle
Definition
Three
Term
Total # of molecules of GTP produced in the citric acid cycle
Definition
One
Term
Total # of molecules of FADH2 produced in the citric acid cycle
Definition
One
Term
Total # of NADH produced in the citric acid cycle
Definition
Three plus one from pyruvate dehydrogenase
Term
Pyruvate is activated/inhibited by BLANK
Definition
Phosphorylation as controlled by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphotase
Term
ATP and NADH (inhibit/activate) pyruvate dehydrogenase
Definition
Inhibit
Term
ADP is inhibited by BLANK in the steps before the citric acid cycle
Definition
acetyl-CoA
Term
Control steps of the citric acid cycle
Definition
Pyruvate dehydrogenation, step 1, step 3 and step 4
Term
All the control steps are inhibited by BLANK
Definition
ATP
Term
What does the glyxoxylate cycle do?
Definition
Converts acetyl CoA into carbs in plants and bacteria
Term
BLANK does not occur in the glyxoxylate cycle
Definition
Oxidation
Term
Lipids are fed into the citric acid cycle at
Definition
Acetyl CoA
Term
Amino acids are fed into the citric acid cycle at
Definition
Various steps
Term
What keeps the citric acid cycle going?
Definition
Oxaloacetate
Term
Source of oxaloacetete is
Definition
Pyruvate
Term
BLANK from the citric acid cycle can be converted to oxaloacetate
Definition
Malate
Term
Which enzyme converts malate into oxaloacetate
Definition
Malate dehydrogenase
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