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Ch 10: Mitosis
Mitosis, cell cycle, how cells divide
56
Biology
Undergraduate 1
11/10/2008

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Term
binary fission
Definition
simplest form of cell division
Term
septum
Definition
new membrane that partitions a cell in binary division
Term
septation
Definition
process of septum creation, in binary fission
Term
condensin
Definition
protein scaffolding that helps in folding DNA for condensing
Term
homologue
Definition
one of pair of matching chromosomes
Term
cohesions
Definition
complex of proteins that hold togeher two identical DNA molecules in division
Term
chromatid
Definition
one of the pair of matching sister chromosomes
Term
S
Definition
synthesis phase: DNA synthesized; some organelles replicated
Term
G1 activities
Definition
growth phase between cytokensis and DNA replication
Term
S activities
Definition
synthesis replica of genome
Term
G2 phase
Definition
Gap 2: preparations made for seperation of newly replicated DNA. mitochondria replicate. some organelles replicated
Term
Mitosis phase activities
Definition
spindle appears, sister chromatis pulled apart
Term
cytokenesis
Definition
contracting ring of actin; in plants a plate forms of cell wall
Term
interphase
Definition
name for G1, S, G2 combined
Term
G0 phase
Definition
replication stops. may stop indefinitely such as in muscle cells
Term
centromere
Definition
point of contraction on centromere
Term
kinetochore
Definition
disklike structure that connects microtublues to chromosome
Term
tubulin
Definition
protein that makes up microtubules
Term
during prophase what happens?
Definition
mitotic apparatus appears. Condensation begins. nuclear envelope disappears
Term
during prometaphase what happens?
Definition
chromosomes attach to spindle, move to cell center
Term
during metaphrase what happens?
Definition
centromeres aligh: metaphase plate
Term
during anaphase what happens?
Definition
chromatids seperate, cell becomes elongated
Term
during telophase what happens?
Definition
nucleus reforms. Chromatids are now chromosomes because they no longer are with a matching pair. Uncoil begins. Reversal of Prophase
Term
clevage furrow
Definition
narrowing between a cell as it's splitting in two
Term
middle lamella
Definition
space between two new cells in plant where new cell wall is formed out of pectins
Term
MDF
Definition
maturing promotion factor. fluctuates with cell cycle.
Term
cyclins
Definition
proteins that are produced in synch with cell cycles; no enyzmatic activity (only seen as markers)
Term
START
Definition
starting point of commitment of DNA synthesis - commitment to mitosis
Term
cdc2
Definition
critical gene for passing boundries in cycle
Term
MPF is _ plus _
Definition
cyclin plus cdc2
Term
Cdk
Definition
cyclin dependent kinease - a protein kinease enzyme that is only active when mixed with cyclin
Term
G1/S
Definition
checkpoint one: decides when to divide
Term
g2/M
Definition
second checkpoint; stimulus for events of mitosis
Term
spindle checkpoint
Definition
all chromosomes attached in prep for Anaphase
Term
APC
Definition
anaphase promoting complex
Term
function of APC
Definition
frees sister chromatids by marking the securing protein (glue)
Term
securin
Definition
protein that holds sister chromatids together; broken down with help from anaphase-promoting complex
Term
separase
Definition
protease specific for releasing the securin adhesion between chromosomes
Term
cohesion protein
Definition
replaces condensin protein in scaffolding of DNA; removed by sister chromatids during chromosome condensation
Term
PDGF stands for:
Definition
Platlet Derived Growth Factor
Term
platlet derived growth factor (PDGF)
Definition
growth factors that trigger receptors on cell membrane
Term
serum vs plasma (blood)
Definition
serum : liquid that remains after clotting
plasma: no clotting
Term
p53
Definition
one gene which plays role in G1 checkpoint; tumor suppressor
Term
oncogenes
Definition
genes that when added triggered cancer
Term
proto-oncogenes
Definition
mutated genes which turn into oncogenes
Term
Rb gene
Definition
retinoblastoma susceptible gene: eye cancer gene
Term
kinease
Definition
A protein which phosphorilates (adds phosphorous) to a wide variety of substances.
Term
30nm fiber
Definition
nucleosomes further coiled into a fiber; common in interphase
Term
APOPTOSIS
Definition
programmed cell death
Term
organelle makes enzymes for apoptosis
Definition
lysosomes
Term
cycline dependent kinases
Definition
phosphorolated / dephosphorlated; stimulate cell division
Term
How do we know cell is dividing?
Definition
chromosomes visible and condensed
Term
polar microtubles
Definition
pole to pole microtubles
Term
kinetochore micortubule
Definition
microtubule that connects to kinetocore
Term
phosphorlated is activated or deactivaed?
Definition
activated
Term
casases
Definition
proteins which destroy cell if checkpoint fails
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