Shared Flashcard Set

Details

CF
Exam review
25
Medical
Undergraduate 3
03/13/2012

Additional Medical Flashcards

 


 

Cards

Term

What are the predominant features of cystic fibrosis in the advance stages

Definition
 Excessive bronchial secretions, bronchial obstruction, and hyperinflation of the lungs
Term

The major pathologic/structural changes associated with cystic fibrosis:

Definition

o   Excessive production and accumulation of thick, tenacious mucus in the tracheobronchial tree

o   Partial bronchial obstruction (mucous plugging)

o   Hyperinflation of the alveoli

o   Total bronchial obstruction (mucous plugging)

o   Atelectasis

Term

What is Cystic Fibrosis

Definition
 an autosomal recessive gene disorder caused by mutations in a pair of genes located on chromosome 7
Term

There are over ____ different mutations of CF

Definition
1000
Term

  The abnormal expression of CTFR results in abnormal transport of ____ and ____ across many types of epithelial surfaces, including surfaces, including those lining the bronchial airways, intestines, pancreas, liver ducts, sweat glands, and vas deferens

Definition
sodium and chloride
Term

 Patients with CF have trouble digesting ____ and ____

Definition
protein and fat
Term

What is Meconium ileus-

Definition
 a blockage of the intestine
Term

  Most ___ with CF are infertile and  In ____ it is uncommon to be infertile

Definition
men; woman
Term
CF is a ___ gene disorder
Definition
recessive
Term

Cystic Fibrosis affects ____children and adults in the U.S.

Definition
30,000
Term

The predicted median life expectancy is ___ years

Definition
37
Term

 Death is usually caused by ____

Definition
pulmonary complications
Term

What is the gold standard Diagnostic test for cystic fibrosis and what does it measure?

Definition
Sweat test; it measures the amount of sodium and chloride in the patient’s sweat
Term

 In children, a sweat chloride concentration greater than __ mEq/L is considered to be a diagnostic sign of the disease… In adults it’s ___ mEq/L

Definition
60; 80
Term

 An immunoreactive trypsinogen test (IRT) may be ordered as an initial test for

Definition

o   Babies who are not creating enough sweat to perform a sweat  test

o   Infants with meconium ileus

o   Children and adults with signs and symptoms associated with cystic fibrosis and pancreatic dysfunction

Term

During an IRT test, a blood sample is analyzed ___ for a specific protein called ____

Definition
twice;  trypsinogen
Term

What does the stool fecal fat test measure?

Definition
 the amount of fat in the infants stool and the percentage of dietary fat that is not absorbed by the body
Term

Nasal electrical potential difference-

Definition
the amount of energy required to move an electrical charge from one point to another in the nasal passages
Term

The genetic test is when

Definition
 a sample of blood is given to test the DNA of the patient for the chromosome that carries cystic fibrosis
Term

  It is estimated that genetic testing can confirm cystic fibrosis in about ___ to ___ % of the patients tested

Definition
80% to 85%
Term

The two prenatal tests used to look for CF are ____ in the first trimester or by ____in the second or third trimester

Definition
chorionic villus biopsy;  amniocentesis
Term

A spontaneous pneumothorax is greater than ___  in adults with CF. When a patient with CF has a pneumothorax, there is a ___ chance that it will recur

Definition
20%; 50%
Term

    Typical findings on a chest x-ray:

Definition

o   Translucent (dark) lung fields

o   Depressed/flattened diaphragms

o   Right ventricular enlargement

o   Areas of atelectasis and fibrosis

Term

The primary goals of cystic fibrosis management are to

Definition
prevent pulmonary infections, reduce the amount of thick bronchial secretions, improve airflow, and provide adequate nutrition
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